Výsledky vyhledávání - "Akash Bhattacharya"

Akademický článek

Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

Autor: Corey H. Yu, Akash Bhattacharya, Mirjana Persaud, Alexander B. Taylor, Zhonghua Wang, Angel Bulnes-Ramos, Joella Xu, Anastasia Selyutina, Alicia Martinez-Lopez, Kristin Cano, Borries Demeler, Baek Kim, Stephen C. Hardies, Felipe Diaz-Griffero, Dmitri N. Ivanov

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

SAMHD1 catalyses the dephosphorylation of deoxynucleotide triphosphates (dNTPs) and has antiretroviral activity. Here, the authors present the crystal structures of SAMHD1-oligonucleotide complexes, which reveal that the allosteric binding sites of S

Externí odkaz: https://doaj.org/article/235030ae21f844b790931e36a84dca12

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Akademický článek

A Spiking Neural Network Model of the Lateral Geniculate Nucleus on the SpiNNaker Machine

Autor: Basabdatta Sen-Bhattacharya, Teresa Serrano-Gotarredona, Lorinc Balassa, Akash Bhattacharya, Alan B. Stokes, Andrew Rowley, Indar Sugiarto, Steve Furber

Publikováno v: Frontiers in Neuroscience, Vol 11 (2017)

We present a spiking neural network model of the thalamic Lateral Geniculate Nucleus (LGN) developed on SpiNNaker, which is a state-of-the-art digital neuromorphic hardware built with very-low-power ARM processors. The parallel, event-based data proc

Externí odkaz: https://doaj.org/article/9341dc8dd83b45959505383f22e5caf2

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Akademický článek

Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation.

Autor: Zhonghua Wang, Akash Bhattacharya, Dmitri N Ivanov

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0138780 (2015)

The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in their 3' or 5' untranslated region (UTR). Multiple lines of experimental eviden

Externí odkaz: https://doaj.org/article/1e969db823e04982b0b509f794e85f87

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Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification

Autor: Akash Bhattacharya, Corey H. Yu, Kristin E. Cano, Anastasia Selyutina, Angel Bulnes-Ramos, Baek Kim, Alicia Martinez-Lopez, Zhonghua Wang, Joella Xu, Stephen C. Hardies, Dmitri N. Ivanov, Mirjana Persaud, Alexander B. Taylor, Felipe Diaz-Griffero, Borries Demeler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications

SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (dNTPs)—implicates enzymatic dNTP depletion in innate antiviral immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0adc5c0b5e9fcc676c2ad9f3e3ed13c
https://doaj.org/article/235030ae21f844b790931e36a84dca12

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