Carbamylated Erythropoietin Decreased Proliferation and Neurogenesis in the Subventricular Zone, but Not the Dentate Gyrus, After Irradiation to the Developing Rat Brain

Autor: Kazuhiro Osato, Yoshiaki Sato, Akari Osato, Machiko Sato, Changlian Zhu, Marcel Leist, Hans G. Kuhn, Klas Blomgren

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Cranial radiotherapy for pediatric brain tumors causes progressive, debilitating late effects, including cognitive decline. Erythropoietin (EPO) has been shown to be neuroprotective and to promote neuroregeneration. Carbamylated erythropoietin (CEPO)

Externí odkaz: https://doaj.org/article/4c52ae289c6a4570890a7cfc09964bb4

Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation

Autor: Machiko Sato, Guido Kroemer, Hans-Georg Kuhn, Kazuhiro Osato, John Swanpalmer, Yoshiaki Sato, Nazanine Modjtahedi, Akari Osato, Tomoyo Ochiishi, Klas Blomgren, Changlian Zhu

Publikováno v: Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2010, 1 (10), pp.e84-e84. ⟨10.1038/cddis.2010.63⟩
Cell Death & Disease

Cranial radiotherapy in children often leads to progressive cognitive decline. We have established a rodent model of irradiation-induced injury to the young brain. A single dose of 8 Gy was administered to the left hemisphere of postnatal day 10 (P10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe675fd6fcc2fb718fdaf1267d475b9
https://hal.archives-ouvertes.fr/hal-02356571