Phylogenetic ctDNA analysis depicts early stage lung cancer evolution

Autor: Abbosh, C, Birkbak, NJ, Wilson, GA, Jamal-Hanjani, M, Constantin, T, Salari, R, Quesne, JL, Moore, DA, Veeriah, S, Rosenthal, R, Marafioti, T, Kirkizlar, E, Watkins, TBK, McGranahan, N, Ward, S, Martinson, L, Riley, J, Fraioli, F, Bakir, MA, GrÖnroos, E, Zambrana, F, Endozo, R, Bi, WL, Fennessy, FM, Sponer, N, Johnson, D, Laycock, J, Shafi, S, Czyzewska-Khan, J, Rowan, A, Chambers, T, Matthews, N, Turajlic, S, Hiley, C, Lee, SM, Forster, MD, Ahmad, T, Falzon, M, Borg, E, Lawrence, D, Hayward, M, Kolvekar, S, Panagiotopoulos, N, Janes, SM, Thakrar, R, Ahmed, A, Blackhall, F, Summers, Y, Hafez, D, Naik, A, Ganguly, A, Kareht, S, Shah, R, Joseph, L, Quinn, AM, Crosbie, P, Naidu, B, Middleton, G, Langman, G, Trotter, S, Nicolson, M, Remmen, H, Kerr, K, Chetty, M, Gomersall, L, Fennell, DA, Nakas, A, Rathinam, S, Anand, G, Khan, S, Russell, P, Ezhil, V, Ismail, B, Irvin-sellers, M, Prakash, V, Lester, JF, Kornaszewska, M, Attanoos, R, Adams, H, Davies, H, Oukrif, D, Akarca, AU, Hartley, JA, Lowe, HL, Lock, S, Iles, N, Bell, H, Ngai, Y, Elgar, G, Szallasi, Z, Schwarz, RF, Herrero, J, Stewart, A, Quezada, SA, Van Loo, P, Dive, C, Lin, CJ, Rabinowitz, M, Aerts, HJWL, Hackshaw, A, Shaw, JA, Zimmermann, BG, Swanton, C, Bosshard-Carter, L, Goh, G, Gorman, P, Murugaesu, N, Hynds, RE, Wilson, G, Horswell, S, Al Bakir, M, Mitter, R, Escudero, M, Xu, H, Goldman, J, Stone, RK, Denner, T, Biggs, J, Costa, M, Begum, S, Phillimore, B, Nye, E, Graca, S, Joshi, K, Furness, A, Aissa, AB, Wong, YNS, Georgiou, A, Quezada, S, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Forster, M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Taylor, M, Choudhary, J, Califano, R, Taylor, P, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Moss, S, Idries, F, Bishop, P, Chaturved, A, Marie Quinn, A, Doran, H, leek, A, Harrison, P, Moore, K, Waddington, R, Novasio, J, Rogan, J, Smith, E, Tugwood, J, Brady, G, Rothwell, DG, Chemi, F, Pierce, J, Gulati, S, Bellamy, M, Bancroft, H, Kerr, A, Kadiri, S, Webb, J, Djearaman, M, Fennell, D, Le Quesne, J, Moore, D, Thomas, A, Walter, H, Monteiro, W, Marshall, H, Nelson, L, Bennett, J, Primrose, L, Amadi, A, Palmer, S, Miller, J, Buchan, K, Lester, J, Edwards, A, Morgan, F, Verjee, A, MacKenzie, M, Wilcox, M, Smith, S, Gower, N, Ottensmeier, C, Chee, S, Johnson, B, Alzetani, A, Shaw, E, Lim, E, De Sousa, P, Tavares Barbosa, M, Bowman, A, Jordan, S, Rice, A, Raubenheimer, H, Proli, C, Elena Cufari, M, Ronquillo, JC, Kwayie, A, Bhayani, H, Hamilton, M, Bakar, Y, Mensah, N, Ambrose, L, Devaraj, A, Buderi, S, Finch, J, Azcarate, L, Chavan, H, Green, S, Mashinga, H, Nicholson, AG, Lau, K, Sheaff, M, Schmid, P, Conibear, J, Light, T, Horey, T, Danson, S, Bury, J, Edwards, J, Hill, J, Matthews, S, Kitsanta, Y, Suvarna, K, Fisher, P, Keerio, AD, Shackcloth, M, Gosney, J, Postmus, P, Feeney, S, Asante-Siaw, J, Constatin, T, Zimmermann, B, Dentro, S, Dessimoz, C, Shiu, K-K, Bridgewater, J, Hochauser, D, Beck, S, Parker, P, Walczak, H, Enver, T, Proctor, I, Sinclair, R, Lok, C-W, Mitchison, M, Trevisan, G, Lynch, M, Brandner, S, Gishen, F, Tookman, A, Stone, P, Sterling, C, Larkin, J, Attard, G, Eeles, R, Foster, C, Bova, S, Sottoriva, A, Chowdhury, S, Ashish, C, Spicer, J, Stares, M, Lynch, J, Caldas, C, Brenton, J, Fitzgerald, R, Jimenez-Linan, M, Provenzano, E, Cluroe, A, Stewart, G, Watts, C, Gilbertson, R, McDermott, U, Tavare, S, Maughan, T, Tomlinson, I, Campbell, P, McNeish, I, Biankin, A, Chambers, A, Fraser, S, Oien, K, Krebs, M, Marais, R, Carter, L, Nonaka, D, Dhomen, N, Shaw, J, Baijal, S, Tanchel, B, Collard, M, Cockcroft, P, Taylor, J, Colloby, P, Olisemeke, B, Wilson, R, Harrison, D, Loda, M, Flanagan, A, McKenzie, M, Lederman, J, Sharp, A, Farrelly, L

Publikováno v: Nature, vol. 545, no. 7655, pp. 446-451

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488928e0797fc6a75de4915f82e9cf29
https://orca.cardiff.ac.uk/id/eprint/100264/1/nature22364.pdf

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Autor: Abbosh, C, Birkbak, NJ, Wilson, GA, Jamal-Hanjani, M, Constantin, T, Salari, R, Le Quesne, J, Moore, DA, Veeriah, S, Rosenthal, R, Marafioti, T, Kirkizlar, E, Watkins, TBK, McGranahan, N, Ward, S, Martinson, L, Riley, J, Fraioli, F, Al Bakir, M, Grönroos, E, Zambrana, F, Endozo, R, Bi, WL, Fennessy, FM, Sponer, N, Johnson, D, Laycock, J, Shafi, S, Czyzewska-Khan, J, Rowan, A, Chambers, T, Matthews, N, Turajlic, S, Hiley, C, Lee, SM, Forster, MD, Ahmad, T, Falzon, M, Borg, E, Lawrence, D, Hayward, M, Kolvekar, S, Panagiotopoulos, N, Janes, SM, Thakrar, R, Ahmed, A, Blackhall, F, Summers, Y, Hafez, D, Naik, A, Ganguly, A, Kareht, S, Shah, R, Joseph, L, Marie Quinn, A, Crosbie, PA, Naidu, B, Middleton, G, Langman, G, Trotter, S, Nicolson, M, Remmen, H, Kerr, K, Chetty, M, Gomersall, L, Fennell, DA, Nakas, A, Rathinam, S, Anand, G, Khan, S, Russell, P, Ezhil, V, Ismail, B, Irvin-Sellers, M, Prakash, V, Lester, JF, Kornaszewska, M, Attanoos, R, Adams, H, Davies, H, Oukrif, D, Akarca, AU, Hartley, JA, Lowe, HL, Lock, S, Iles, N, Bell, H, Ngai, Y, Elgar, G, Szallasi, Z, Schwarz, RF, Herrero, J, Stewart, A, Quezada, SA, Peggs, KS, Van Loo, P, Dive, C, Lin, CJ, Rabinowitz, M, Aerts, HJWL, Hackshaw, A, Shaw, JA, Zimmermann, BG, TRACERx Consortium, PEACE Consortium, Swanton, C

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41d01a170bd1c4e5fbb46ddc108ac90c

Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models.

Autor: Hynds RE; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. rob.hynds@ucl.ac.uk.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. rob.hynds@ucl.ac.uk.; Epithelial Cell Biology in ENT Research Group (EpiCENTR), Developmental Biology and Cancer, Great Ormond Street University College London Institute of Child Health, London, UK. rob.hynds@ucl.ac.uk., Huebner A; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Pearce DR; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Hill MS; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Akarca AU; Department of Cellular Pathology, University College London Hospitals, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Ward S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., Gowers KHC; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Karasaki T; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK., Al Bakir M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Wilson GA; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Pich O; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Martínez-Ruiz C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Hossain ASMM; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK., Pearce SP; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK., Sivakumar M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Ben Aissa A; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK., Grönroos E; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Chandrasekharan D; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Kolluri KK; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Towns R; Biological Services Unit, University College London, London, UK., Wang K; School of Medicine, University of Leeds, Leeds, UK., Cook DE; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Bosshard-Carter L; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Naceur-Lombardelli C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Rowan AJ; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK., Veeriah S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Litchfield K; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Tumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UK., Crosbie PAJ; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK.; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK., Dive C; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University of Manchester, Manchester, UK., Quezada SA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK., Janes SM; Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK., Jamal-Hanjani M; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.; Cancer Metastasis Laboratory, University College London Cancer Institute, London, UK.; Department of Oncology, University College London Hospitals, London, UK., Marafioti T; Department of Cellular Pathology, University College London Hospitals, London, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. nicholas.mcgranahan.10@ucl.ac.uk., Swanton C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK. charles.swanton@crick.ac.uk.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK. charles.swanton@crick.ac.uk.; Department of Oncology, University College London Hospitals, London, UK. charles.swanton@crick.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 May 31; Vol. 15 (1), pp. 4653. Date of Electronic Publication: 2024 May 31.

Microenvironmental immune cell alterations across the spectrum of nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B-cell lymphoma.

Autor: Panayi C; Department of Cellular Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Akarca AU; University College London (UCL) Cancer Institute, University College London, London, United Kingdom., Ramsay AD; Department of Cellular Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Shankar AG; Children and Young People's Cancer Services, University College London Hospitals NHS Foundation Trust, London, United Kingdom., Falini B; Institute of Hematology and Center for Haemato-Oncological Research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy., Piris MA; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain., Linch D; Research Department of Haematology, Cancer Institute, University College London, London, United Kingdom., Marafioti T; Department of Cellular Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.; University College London (UCL) Cancer Institute, University College London, London, United Kingdom.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Oct 03; Vol. 13, pp. 1267604. Date of Electronic Publication: 2023 Oct 03 (Print Publication: 2023).

Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer.

Autor: Pearce DR; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Cancer Evolution and Genome Stability Laboratory, The Francis Crick Institute, London, United Kingdom., Akarca AU; Department of Cellular Pathology, University College London Hospitals, London, United Kingdom., De Maeyer RPH; Division of Medicine, University College London, London, United Kingdom., Kostina E; Epithelial Cell Biology in ENT Research (EpiCENTR) Group, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Huebner A; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Cancer Evolution and Genome Stability Laboratory, The Francis Crick Institute, London, United Kingdom.; Cancer Genome Evolution Research Group, UCL Cancer Institute, University College London, London, United Kingdom., Sivakumar M; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Department of Cellular Pathology, University College London Hospitals, London, United Kingdom., Karasaki T; Cancer Evolution and Genome Stability Laboratory, The Francis Crick Institute, London, United Kingdom., Shah K; Division of Medicine, University College London, London, United Kingdom., Janes SM; Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom., McGranahan N; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Cancer Genome Evolution Research Group, UCL Cancer Institute, University College London, London, United Kingdom., Reddy V; Division of Medicine, University College London, London, United Kingdom., Akbar AN; Division of Medicine, University College London, London, United Kingdom., Moore DA; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Department of Cellular Pathology, University College London Hospitals, London, United Kingdom., Marafioti T; Department of Cellular Pathology, University College London Hospitals, London, United Kingdom., Swanton C; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Cancer Evolution and Genome Stability Laboratory, The Francis Crick Institute, London, United Kingdom., Hynds RE; Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, United Kingdom.; Cancer Evolution and Genome Stability Laboratory, The Francis Crick Institute, London, United Kingdom.; Epithelial Cell Biology in ENT Research (EpiCENTR) Group, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Jun 05; Vol. 13, pp. 1156743. Date of Electronic Publication: 2023 Jun 05 (Print Publication: 2023).