Výsledky vyhledávání - "Akanksha GANGAR"

Abstract 585: Induction of immunogenic cell death and enhancement of dendritic cell function: Development of an in vitro, ex vivo ICD platform for the identification of novel ICD inducers

Autor: Didier Grillot, Fabrice Viviani, Akanksha Gangar, Raphaelle Guillard-Huet, Jean-François Mirjolet

Publikováno v: Cancer Research. 79:585-585

Immunological cell death (ICD) is a form of cancer cell death induced by radiotherapy, photodynamic therapy and a few chemotherapeutic agents such as Doxorubicin, Mitoxantrone, and Oxaliplatin. Unlike apoptosis or necrosis, ICD can induce an effectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0aca5d55c2072fbaa3a9213e6d851f09
https://doi.org/10.1158/1538-7445.am2019-585

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Abstract 782: Development of a high throughput in vitro screening platform to identify novel inducers of immunological cell death

Autor: Jean-François Mirjolet, Florent Potvain, Raphaelle Guillard-Huet, Guillaume Serin, Didier Grillot, Akanksha Gangar, Eric Boursier

Publikováno v: Cancer Research. 78:782-782

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48a0828a0909a71a277e6ed10ad0c0cb
https://doi.org/10.1158/1538-7445.am2018-782

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The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p

Autor: Patrick Brennwald, Sherry Niessen, Akanksha Gangar, Peter Novick, Anna Andreeva, John R. Yates, Bianka L. Grosshans

Publikováno v: The Journal of Cell Biology

Rab guanosine triphosphatases regulate intracellular membrane traffic by binding specific effector proteins. The yeast Rab Sec4p plays multiple roles in the polarized transport of post-Golgi vesicles to, and their subsequent fusion with, the plasma m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3447fe9ed5a40679d07b9e06a8bf1dcd
https://doi.org/10.1083/jcb.200510016

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Alteration in the cytosolic triacylglycerol biosynthetic machinery leads to decreased cell growth and triacylglycerol synthesis in oleaginous yeast

Autor: Ram Rajasekharan, Sumana Raychaudhuri, Akanksha Gangar

Publikováno v: Biochemical Journal. 365:577-589

Altered nutrient content (levels of glucose) caused a drastic reduction in cell growth and triacylglycerol (TAG) production in the wild-type (WT) Rhodotorula glutinis. This was due to the decreased level of synthesis of TAG biosynthetic enzymes, refl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df250edb77a406b889c051b376ae49bd
https://doi.org/10.1042/bj20011654

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The Human PDZome: A Gateway to PSD95-Disc Large-Zonula Occludens (PDZ)-mediated Functions

Autor: Frédérique Lembo, Jean-Claude Lissitzky, Marie-Josée Santoni, Nicolas Lenfant, Michael Sebbagh, Jérôme Reboul, Stephane Angers, Jolanta Polanowska, Michel Aurrand-Lions, Avais M. Daulat, Virginie Thomé, Stéphane Audebert, Akanksha Gangar, Mireille Montcouquiol, Karim Blibek, Laurent Kodjabachian, Shizue Omi, Jean-Paul Borg, Edwige Belotti

Publikováno v: Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2013, 12 (9), pp.2587-603. 〈10.1074/mcp.O112.021022〉
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics, 2013, 12 (9), pp.2587-603. ⟨10.1074/mcp.O112.021022⟩
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2013, 12 (9), pp.2587-603. ⟨10.1074/mcp.O112.021022⟩

International audience; Protein-protein interactions organize the localization, clustering, signal transduction, and degradation of cellular proteins and are therefore implicated in numerous biological functions. These interactions are mediated by sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6a2d07ef1cf0eb998f28e6f41adbf
https://hal.archives-ouvertes.fr/hal-00862192

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Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling

Autor: Anne Catherine Lhoumeau, Edwige Belotti, Sylvie Marchetto, Michael Sebbagh, Frédérique Lembo, Seung Taek Lee, Francesca Puppo, Akanksha Gangar, Jean-Paul Borg, Virginie Thomé, Marie Cibois, Laurent Kodjabachian, Thomas Prebet, Won Sik Shin, Patrick Lécine

Publikováno v: EMBO Reports
EMBO Reports, 2011, 12, pp.43-49. ⟨10.1038/embor.2010.185⟩
EMBO Reports, EMBO Press, 2011, 12, pp.43-49. ⟨10.1038/embor.2010.185⟩
EMBO Reports, EMBO Press, 2011, 12 (1), pp.43-9. ⟨10.1038/embor.2010.185⟩
EMBO Reports, 2011, 12 (1), pp.43-9. ⟨10.1038/embor.2010.185⟩

International audience; The receptor protein tyrosine kinase 7 (PTK7) was recently shown to participate in noncanonical Wnt/planar cell polarity signalling during mouse and frog embryonic development. In this study, we report that PTK7 interacts with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a85b59893c1d5ca6b4130dc3e0af91
https://hal.science/hal-00566856

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Pharmacological properties of acid N -thiazolylamide FFA2 agonists

Autor: Simon J. Dowell, Andrew J. Brown, Forhad Chowdhury, Nicolas Faucher, Tony W. Dean, Elaine Gower, Nisha Bhudia, Emma Ward, Christina Tsoulou, Akanksha Gangar

Publikováno v: Pharmacology Research & Perspectives

FFA2 is a receptor for short-chain fatty acids. Propionate (C3) and 4-chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide (4-CMTB), the prototypical synthetic FFA2 agonist, evoke calcium mobilization in neutrophils and inhibit lipolysis in adipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b832bd404e7c9e91876819f81394441
https://doi.org/10.1002/prp2.141

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Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism

Autor: Akanksha Gangar, William I. Weis, Patrick Brennwald, Anna Andreeva, Douglas A. Hattendorf

Publikováno v: Nature. 446(7135)

The crystal structure of Sro7 and its interaction with the SNARE Sec9p is described. The structure reveals two WD40 β-propeller domains followed by a 60-residue tail. A mutant lacking the tail binds to the SNARE domain of Sec9 and inhibits assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcc9a88e34705b2f33d243465d31058
https://pubmed.ncbi.nlm.nih.gov/17392788

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Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis

Autor: Akanksha Gangar, Puyue Wang, Patrick Brennwald, Jian Zhang, Wei Guo, Daniel TerBush, Xiaoyu Zhang

Publikováno v: The Journal of Cell Biology

The tumor suppressor lethal giant larvae (Lgl) plays a critical role in epithelial cell polarization. However, the molecular mechanism by which Lgl carries out its functions is unclear. In this study, we report that the yeast Lgl proteins Sro7p and S

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Purification and characterization of acyl-acyl carrier protein synthetase from oleaginous yeast and its role in triacylglycerol biosynthesis

Autor: Akanksha GANGAR, Anjali A. KARANDE, Ram RAJASEKHARAN

Publikováno v: IndraStra Global.

Fatty acids are activated in an ATP-dependent manner before they are utilized. We describe here how the 10S triacylglycerol biosynthetic multienzyme complex from Rhodotorula glutinis is capable of activating non-esterified fatty acids for the synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8644e54e0f139acbd55bae1fe438235d
http://eprints.iisc.ac.in/10596/1/3600471.pdf

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