Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Akane Komatsu"'
Autor:
Masahiro Yamaguchi, Kanako Miyano, Shigeto Hirayama, Yusuke Karasawa, Kaori Ohshima, Eiko Uezono, Akane Komatsu, Miki Nonaka, Hideaki Fujii, Keisuke Yamaguchi, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono
Publikováno v:
Molecules, Vol 27, Iss 20, p 7065 (2022)
Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects. The selective κOR agonist nalfurafine was initi
Externí odkaz:
https://doaj.org/article/a7b83951f1a546df8ff51977d03aab6c
Autor:
Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 426 (2022)
The issue of tolerance to continuous or repeated administration of opioids should be addressed. The ability of ketamine to improve opioid tolerance has been reported in clinical studies, and its mechanism of tolerance may involve improved desensitiza
Externí odkaz:
https://doaj.org/article/d1b1c66c5db7400385d1f700d98cb702
Autor:
Yusuke Karasawa, Kanako Miyano, Hideaki Fujii, Takaaki Mizuguchi, Yui Kuroda, Miki Nonaka, Akane Komatsu, Kaori Ohshima, Masahiro Yamaguchi, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida
Publikováno v:
Molecules, Vol 26, Iss 19, p 6079 (2021)
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid ago
Externí odkaz:
https://doaj.org/article/a746c1736c1b40f1b6a4b84d1774790b
Autor:
Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono
Publikováno v:
Cells, Vol 10, Iss 10, p 2651 (2021)
Oxytocin (OT) influences various physiological functions such as uterine contractions, maternal/social behavior, and analgesia. Opioid signaling pathways are involved in one of the analgesic mechanisms of OT. We previously showed that OT acts as a po
Externí odkaz:
https://doaj.org/article/f806c283bdad47eeb3f6f5b335c65459
Autor:
Eiko Uezono, Yusuke Mizobuchi, Kanako Miyano, Katsuya Ohbuchi, Hiroaki Murata, Akane Komatsu, Sei Manabe, Miki Nonaka, Takatsugu Hirokawa, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida, Izumi Kawagoe
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8369
Remifentanil (REM) and fentanyl (FEN) are commonly used analgesics that act by activating a µ-opioid receptor (MOR). Although optimal concentrations of REM can be easily maintained during surgery, it is sometimes switched to FEN for optimal pain reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5c9c764f5da9c98bd53727b594eb71
Publikováno v:
Bioscience, Biotechnology & Biochemistry; Dec2023, Vol. 87 Issue 12, p1543-1550, 8p
Publikováno v:
Bioscience, Biotechnology & Biochemistry; Dec2023, Vol. 87 Issue 12, p1543-1550, 8p
Autor:
Sayaka Okazaki1, Akane Komatsu1, Moe Nakano1, Goro Taguchi1, Makoto Shimosaka1 shimosaka2001@gmail.com
Publikováno v:
Bioscience, Biotechnology & Biochemistry. Dec2023, Vol. 87 Issue 12, p1543-1550. 8p.
Autor:
Akane Komatsu, Kanako Miyano, Daisuke Nakayama, Yusuke Mizobuchi, Eiko Uezono, Kaori Ohshima, Yusuke Karasawa, Yui Kuroda, Miki Nonaka, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida
Publikováno v:
Anesthesia and analgesia. 134(5)
Transdermal fentanyl is widely used in the treatment of severe pain because of convenience, safety, and stable blood concentrations. Nevertheless, patients often develop tolerance to fentanyl, necessitating the use of other opioids; transdermal bupre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2123016015d729ee64c30ae92dcb97
https://pubmed.ncbi.nlm.nih.gov/35427270
https://pubmed.ncbi.nlm.nih.gov/35427270
Autor:
Akane Komatsu, Takaaki Mizuguchi, Hideaki Fujii, Yasuhito Uezono, Keisuke Yamaguchi, Kaori Ohshima, Masahiro Yamaguchi, Yusuke Karasawa, Yui Kuroda, Kanako Miyano, Miki Nonaka, Masako Iseki, Masakazu Hayashida
Publikováno v:
Molecules
Volume 26
Issue 19
Molecules, Vol 26, Iss 6079, p 6079 (2021)
Volume 26
Issue 19
Molecules, Vol 26, Iss 6079, p 6079 (2021)
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid ago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b94a9fdd9dda649f58cba8c3f0a775
https://pubmed.ncbi.nlm.nih.gov/34641621
https://pubmed.ncbi.nlm.nih.gov/34641621