Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Akane, Kawamura"'
Autor:
Joanna Bonnici, Razanne Oueini, Eidarus Salah, Catrine Johansson, Elisabete Pires, Martine Abboud, Robert S. Dawber, Anthony Tumber, Patrick Rabe, Hilal Saraç, Christopher J. Schofield, Akane Kawamura
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract 2-Oxoglutarate (2OG) dependent N ε -methyl lysine demethylases (JmjC-KDMs) regulate eukaryotic transcription. We report studies showing that isolated forms of all human KDM4 and KDM5 JmjC enzymes catalyse demethylation of N-methylated Arg-3
Externí odkaz:
https://doaj.org/article/05b29963e9554ce083ab7680ddbc74cd
Autor:
Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinović
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
N ε-methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription, and understanding the extent to which histone N ε-methyllysine readers and erasers can manifest selectivity is of fundamental and
Externí odkaz:
https://doaj.org/article/099bbfd2e1894d158c026e859ca05b14
Autor:
Kuo-Feng Hsu, Sarah E. Wilkins, Richard J. Hopkinson, Rok Sekirnik, Emily Flashman, Akane Kawamura, James S.O. McCullagh, Louise J. Walport, Christopher J. Schofield
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 14-27 (2021)
Post-translational modifications (PTMs) to the tails of the core histone proteins are critically involved in epigenetic regulation. Hypoxia affects histone modifications by altering the activities of histone-modifying enzymes and the levels of hypoxi
Externí odkaz:
https://doaj.org/article/232fbe08a0724f6ca2a8f27be76d1d05
Autor:
Rasheduzzaman Chowdhury, Martine I. Abboud, Tom E. McAllister, Biswadip Banerji, Bhaskar Bhushan, John L. Sorensen, Akane Kawamura, Christopher J. Schofield
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Crystallization is the bottleneck in macromolecular crystallography; even when a protein crystallises, crystal packing often influences ligand-binding and protein–protein interaction interfaces, which are the key points of interest for fun
Externí odkaz:
https://doaj.org/article/7ffb0667b88f4bb4a12b5e6a229217a5
Autor:
Joanna Bonnici, Razanne Oueini, Eidarus Salah, Catrine Johansson, Christopher J. Schofield, Akane Kawamura
Publikováno v:
FEBS Letters. 597:933-946
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a826647064721a8163e3badffd0981
https://doi.org/10.1002/1873-3468.14586
https://doi.org/10.1002/1873-3468.14586
Autor:
Kamayani Singh, Graham Davies, Yara Alenazi, James R. O. Eaton, Akane Kawamura, Shoumo Bhattacharya
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/c6b106d446304fa1b2c20ab7c45a515c
Autor:
Kamayani Singh, Graham Davies, Yara Alenazi, James R. O. Eaton, Akane Kawamura, Shoumo Bhattacharya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Chemokines function via G-protein coupled receptors in a robust network to recruit immune cells to sites of inflammation. Due to the complexity of this network, targeting single chemokines or receptors has not been successful in inflammatory
Externí odkaz:
https://doaj.org/article/b514a9c56ad24d53bfea2339ddae7894
Autor:
Akane Kawamura, Martin Münzel, Tatsuya Kojima, Clarence Yapp, Bhaskar Bhushan, Yuki Goto, Anthony Tumber, Takayuki Katoh, Oliver N. F. King, Toby Passioura, Louise J. Walport, Stephanie B. Hatch, Sarah Madden, Susanne Müller, Paul E. Brennan, Rasheduzzaman Chowdhury, Richard J. Hopkinson, Hiroaki Suga, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
JmjC histone demethylases (KDMs) are cancer targets due to their links to cell proliferation, but selective inhibition remains a challenge. Here the authors identify potent inhibitors of KDM4A-C—viain vitroselection from a vast library of cyclic pe
Externí odkaz:
https://doaj.org/article/ef8ec2f09725496691198a2fa7af4d88
Autor:
Takashi Miura, Tika R. Malla, C. David Owen, Anthony Tumber, Lennart Brewitz, Michael A. McDonough, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin A. Walsh, Akane Kawamura, Christopher J. Schofield, Hiroaki Suga
Publikováno v:
Nature Chemistry.
γ-Amino acids can play important roles in the biological activities of natural products; however, the ribosomal incorporation of γ-amino acids into peptides is challenging. Here we report how a selection campaign employing a non-canonical peptide l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fa95ca8159c4770b4d79fef20d0203
https://doi.org/10.1038/s41557-023-01205-1
https://doi.org/10.1038/s41557-023-01205-1
Autor:
Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Rachel Schiller, Wei Ge, Akane Kawamura, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
While reversal of lysine methylation on histone tails is a well-established mechanism to tune gene expression, the existence of a similar arginine demethylation process is controversial. Here, the authors show that some jumonji enzymes possess both l
Externí odkaz:
https://doaj.org/article/b3dc6971dc6349f5a32b481bb23ad534