Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.

Autor: Ichikawa, Moe¹, Akamine, Hiroki¹, Murata, Michika¹, Ito, Sumito², Takayama, Kazuo¹, Mizuguchi, Hiroyuki^1,3,4,5 mizuguch@phs.osaka-u.ac.jp

Publikováno v: Scientific Reports. 6/3/2021, Vol. 11 Issue 1, p1-9. 9p.

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction.

Autor: Nakamori D; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan., Akamine H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan., Takayama K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan.; PRESTO, Japan Science and Technology Agency, Saitama, 332-0012, Japan.; Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan., Sakurai F; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan.; Laboratory of Regulatory Sciences for Oligonucleotide Therapeutics, Clinical Drug Development Project, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan., Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, 565-0871, Japan. mizuguch@phs.osaka-u.ac.jp.; Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, 567-0085, Japan. mizuguch@phs.osaka-u.ac.jp.; Global Center for Medical Engineering and Informatics, Osaka University, Osaka, 565-0871, Japan. mizuguch@phs.osaka-u.ac.jp.

Publikováno v: Scientific reports [Sci Rep] 2017 Nov 30; Vol. 7 (1), pp. 16675. Date of Electronic Publication: 2017 Nov 30.