Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Akaljot Singh"'
Autor:
Amy E. O’Connell, Sathuwarman Raveenthiraraj, Luiz Fernando Silva Oliveira, Comfort Adegboye, Venkata Siva Dasuri, Wanshu Qi, Radhika S. Khetani, Akaljot Singh, Nambirajam Sundaram, Jasmine Lin, Prathima Nandivada, Lorena Rincón-Cruz, Jeffrey D. Goldsmith, Jay R. Thiagarajah, Diana L. Carlone, Jerrold R. Turner, Pankaj B. Agrawal, Michael Helmrath, David T. Breault
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 2, Pp 101349- (2024)
Background & aims: Humans with WNT2B deficiency have severe intestinal disease, including significant inflammatory injury, highlighting a critical role for WNT2B. We sought to understand how WNT2B contributes to intestinal homeostasis. Methods: We in
Externí odkaz:
https://doaj.org/article/73ecaa07cd064534a6b295fa2a02c92d
Autor:
Akaljot Singh, Holly M Poling, Nambirajan Sundaram, Nicole Brown, James M Wells, Michael A Helmrath
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237885 (2020)
Our group has developed two transplantation models for the engraftment of Human Intestinal Organoids (HIOs): the renal subcapsular space (RSS) and the mesentery each with specific benefits for study. While engraftment at both sites generates laminate
Externí odkaz:
https://doaj.org/article/4df5319f91e4406ea55d08281fbc7442
Autor:
Akaljot Singh, Holly M. Poling, Praneet Chaturvedi, Konrad Thorner, Nambirajan Sundaram, Daniel O. Kechele, Charlie J. Childs, Heather A. McCauley, Garrett W. Fisher, Nicole E. Brown, Jason R. Spence, James M. Wells, Michael A. Helmrath
Publikováno v:
Development. 150
The in vitro differentiation of pluripotent stem cells into human intestinal organoids (HIOs) has served as a powerful means for creating complex three-dimensional intestinal structures. Owing to their diverse cell populations, transplantation into a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee18eec0185fde3097cc380b75f3989
https://doi.org/10.1242/dev.201416
https://doi.org/10.1242/dev.201416
Autor:
Amy E. O’Connell, Sathuwarman Raveenthiraraj, Comfort Adegboye, Wanshu Qi, Radhika S. Khetani, Akaljot Singh, Nambirajam Sundaram, Chidera Emeonye, Jasmine Lin, Jeffrey D. Goldsmith, Jay R. Thiagarajah, Diana L. Carlone, Jerrold R. Turner, Pankaj B. Agrawal, Michael Helmrath, David T. Breault
Publikováno v:
bioRxiv
Background and aimsWNT2B is a canonical Wnt ligand previously thought to be fully redundant with other Wnts in the intestinal epithelium. However, humans with WNT2B deficiency have severe intestinal disease, highlighting a critical role for WNT2B. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f32e2c49e942178dbaff1d00bcd608e
https://doi.org/10.1101/2023.04.21.537894
https://doi.org/10.1101/2023.04.21.537894
Autor:
Akaljot Singh, Holly M. Poling, Nambirajan Sundaram, James Wells, Amy E. O'Connell, Olga Kovbasnjuk, Michael Helmrath
Publikováno v:
Gastroenterology. 162:S-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514fdc9fa37030a1bfab8a45608e7b58
https://doi.org/10.1016/s0016-5085(22)60029-5
https://doi.org/10.1016/s0016-5085(22)60029-5
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology
Gastrointestinal organoids are an exciting new tool for modeling human development, physiology, and disease in human tissue. Derived from pluripotent stem cells, gastrointestinal organoids consist of epithelial and mesenchymal cells organized in an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878d5a9d77303f333b575914c92015ca
https://pubmed.ncbi.nlm.nih.gov/32658619
https://pubmed.ncbi.nlm.nih.gov/32658619
Autor:
Nambirajan Sundaram, James M. Wells, Akaljot Singh, Nicole Brown, Michael A. Helmrath, Holly M. Poling
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237885 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237885 (2020)
Our group has developed two transplantation models for the engraftment of Human Intestinal Organoids (HIOs): the renal subcapsular space (RSS) and the mesentery each with specific benefits for study. While engraftment at both sites generates laminate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c3b6d2531c149a0edacf287d64d1c0
https://pubmed.ncbi.nlm.nih.gov/32853234
https://pubmed.ncbi.nlm.nih.gov/32853234
Autor:
Hyeon Jin Koo, Akaljot Singh, Tianbai Wang, Lucie Karbowski, Gerard A. Ateshian, Krista M. Durney, Michael B. Albro, Danial Sharifi Kia
Publikováno v:
Journal of Biomechanical Engineering. 141
The ability to maintain living articular cartilage tissue in long-term culture can serve as a valuable analytical research tool, allowing for direct examination of mechanical or chemical perturbations on tissue behavior. A fundamental challenge for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb09ea7e4a32ab824502d86cadf5767
https://doi.org/10.1115/1.4041901
https://doi.org/10.1115/1.4041901
Autor:
Michael A. Helmrath, Holly M. Poling, Akaljot Singh, Alexander R. Cortez, Nicole E. Brown, Maxime M. Mahe
Publikováno v:
Surgery
Surgery, Elsevier, 2018, 164 (4), pp.643-650. ⟨10.1016/j.surg.2018.04.048⟩
Surgery, Elsevier, 2018, 164 (4), pp.643-650. ⟨10.1016/j.surg.2018.04.048⟩
We previously described the development of human intestinal organoids from pluripotent stem cells, as well as their in vivo maturation when transplanted into the mouse kidney capsule. While sufficient for certain aspects of study, this model has limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98832aedf06f224e17fd5d0ca5cb4974
https://pubmed.ncbi.nlm.nih.gov/30072251
https://pubmed.ncbi.nlm.nih.gov/30072251