Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Akachukwu Ibezim"'
Autor:
Akachukwu Ibezim, Emmanuel Onah, Sochi Chinaemerem Osigwe, Peter Ukwu Okoroafor, Onyeoziri Pius Ukoha, Jair Lage de Siqueira-Neto, Fidele Ntie-Kang, Karuppasamy Ramanathan
Publikováno v:
Scientific African, Vol 24, Iss , Pp e02226- (2024)
Hexokinases (Hks) and mitochondrial complex I (MCI) are involved in the energy metabolism of cells; glycolysis/fermentation and oxidative phosphorylation. Both Hks and MCI are known to play critical roles in either division of metabolic plasticity wh
Externí odkaz:
https://doaj.org/article/7ea008155e0f4fa6b3feaa9455870ef6
Autor:
Emmanuel Onah, Philip F. Uzor, Ikenna Calvin Ugwoke, Jude Uche Eze, Sunday Tochukwu Ugwuanyi, Ifeanyi Richard Chukwudi, Akachukwu Ibezim
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background In most parts of the world, especially in underdeveloped countries, acquired immunodeficiency syndrome (AIDS) still remains a major cause of death, disability, and unfavorable economic outcomes. This has necessitated intensive res
Externí odkaz:
https://doaj.org/article/5b26565151ea400f95ad901cf3185b0c
Autor:
Akachukwu Ibezim, Martha N. Ofokansi, Xavier Ndukwe, Chidera S. Chiama, Bonaventure C. Obi, Ogechukwu N. Isiogugu, Peter E. Ikechukwu, Akachukwu M. Onwuka, Stella A. Ihim, Jonnie N. Asegbeloyin, Ngozi J. Nwodo
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-9 (2022)
Abstract Background The search for pharmacologically effective agents among molecules bearing multiple functionalities is commonly practiced. In continuation of the search for new anti-malarial agents, new pyrazole-hydrazine coupled Schiff-base deriv
Externí odkaz:
https://doaj.org/article/2a7e12e647ca4871b11719d947e3bd9a
Autor:
Akachukwu Ibezim, Mbanefo S. Madukaife, Sochi C. Osigwe, Nadja Engel, Ramanathan Karuppasamy, Fidele Ntie-Kang
Publikováno v:
BMC Chemistry, Vol 16, Iss 1, Pp 1-9 (2022)
Abstract Type III beta phosphatidylinositol 4-kinase (PI4KIIIβ) is the only clinically validated drug target in Plasmodium kinases and therefore a critical target in developing novel drugs for malaria. Current PI4KIIIβ inhibitors have solubility an
Externí odkaz:
https://doaj.org/article/6a6ea292690840adaf99867b801cc5f7
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Psoriasis is an autoimmune inflammatory skin disease that affects 0.5–3% of the world’s population and current treatment options are posed with limitations. The reduced risk of failure in clinical trials for repositioned drug
Externí odkaz:
https://doaj.org/article/529accd2c7004afdb754a3fc5fd5970b
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0243305 (2021)
Carboxamides bearing sulphonamide functionality have been shown to exhibit significant lethal effect on Plasmodium falciparum, the causative agent of human malaria. Here we report the synthesis of thirty-two new drug-like sulphonamide pyrolidine carb
Externí odkaz:
https://doaj.org/article/ddccc423ae034f16933175f5a15bfb5e
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e04958- (2020)
Twenty-three new series of toluene-sulfonamide dipeptide derivatives were synthesized and screened for antiplasmodial and antioxidant potencies. Many of the derivatives were active against Plasmodium falciparum with IC50 ranging from 3.20 – 9.10 μ
Externí odkaz:
https://doaj.org/article/7550c4de3fc746aabef7b9714d970e16
Autor:
Fredrick C. Asogwa, Akachukwu Ibezim, Fidele Ntie-Kang, Chioma J. Asogwa, Chukwuma O.B. Okoye
Publikováno v:
Scientific African, Vol 7, Iss , Pp - (2020)
Psorospermum febrifugum Spach is a flowering plant belonging to the family Hypericaceae. It has a long history for its use in folk-loric medicines as a remedy for leprosy, epilepsy, insomnia, anxiety, subcutaneous wounds and skin diseases. The study
Externí odkaz:
https://doaj.org/article/fe7f938f33fe4bd7a0942cc74ccfdc7d
Autor:
Ngozi Justina Nwodo, Akachukwu Ibezim, Fidele Ntie-Kang, Michael Umale Adikwu, Chika John Mbah
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 7750-7771 (2015)
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally. Nigerian medicinal plants are known to contain a large variety of chemical structures and some o
Externí odkaz:
https://doaj.org/article/b7f65ad54cc24a83a5a8ed47677206ec
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170150 (2017)
The Antibiogram properties of 1-chloro-2-isocyanatoethane derivatives of thiomorpholine (CTC), piperazine (CPC) and morpholine (CMC) were evaluated by the approved agar well diffusion, the minimum inhibitory concentration (MIC) and in silico techniqu
Externí odkaz:
https://doaj.org/article/2c69d90fe3eb43c2a11172e8be31d518