Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

Autor: Caussy, C, Hsu, C, Lo, MT, Liu, A, Bettencourt, R, Ajmera, VH, Bassirian, S, Hooker, J, Sy, E, Richards, L, Schork, N, Schnabl, B, Brenner, DA, Sirlin, CB, Chen, CH, Loomba, R

Publikováno v: Caussy, C; Hsu, C; Lo, MT; Liu, A; Bettencourt, R; Ajmera, VH; et al.(2018). Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology, 68(3), 918-932. doi: 10.1002/hep.29892. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2g381354

© 2018 by the American Association for the Study of Liver Diseases. Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease (NAFLD). We aimed to examine if serum metabolites, especially those derived from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::ce5f5d93404ae4eb0ac4d130f38dd400
http://www.escholarship.org/uc/item/2g381354

Machine learning enables new insights into genetic contributions to liver fat accumulation.

Autor: Haas ME; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Molecular Biology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; These authors contributed equally., Pirruccello JP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Machine Learning for Health, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; These authors contributed equally., Friedman SN; Machine Learning for Health, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; These authors contributed equally., Wang M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Emdin CA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA., Ajmera VH; NAFLD Research Center, Department of Medicine, University of California San Diego, La Jolla, CA 92103, USA., Simon TG; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.; Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Homburger JR; Color Health, Burlingame, CA 94010, USA., Guo X; The Lundquist Institute for Biomedical Innovation and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Budoff M; The Lundquist Institute for Biomedical Innovation and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Corey KE; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.; Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Zhou AY; Color Health, Burlingame, CA 94010, USA., Philippakis A; Machine Learning for Health, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ellinor PT; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Machine Learning for Health, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Loomba R; NAFLD Research Center, Department of Medicine, University of California San Diego, La Jolla, CA 92103, USA., Batra P; Machine Learning for Health, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Khera AV; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Machine Learning for Health, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Lead contact.

Publikováno v: Cell genomics [Cell Genom] 2021 Dec 08; Vol. 1 (3).

Optimal Threshold of Controlled Attenuation Parameter for Detection of HIV-Associated NAFLD With Magnetic Resonance Imaging as the Reference Standard.

Autor: Ajmera VH; NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California, USA.; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Cachay ER; Division of Infectious Diseases, Owen Clinic, University of California San Diego, San Diego, California, USA., Ramers CB; Laura Rodriguez Research Institute, Family Health Centers of San Diego, San Diego, California, USA., Bassirian S; NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Singh S; NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Bettencourt R; NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Richards L; NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Hamilton G; Liver Imaging Group, University of California, San Diego, La Jolla, California, USA., Middleton M; Liver Imaging Group, University of California, San Diego, La Jolla, California, USA., Fowler K; Liver Imaging Group, University of California, San Diego, La Jolla, California, USA., Sirlin C; Liver Imaging Group, University of California, San Diego, La Jolla, California, USA., Loomba R; NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California, USA.; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA.; Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Jun 15; Vol. 72 (12), pp. 2124-2131.

Clinical Utility of an Increase in Magnetic Resonance Elastography in Predicting Fibrosis Progression in Nonalcoholic Fatty Liver Disease.

Autor: Ajmera VH; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA.; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA., Liu A; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Singh S; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Yachoa G; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Ramey M; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Bhargava M; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Zamani A; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Lopez S; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Mangla N; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Bettencourt R; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Rizo E; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Valasek M; Department of Pathology, University of California at San Diego, La Jolla, CA., Behling C; Department of Pathology, Sharp Medical Group, San Diego, CA., Richards L; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA., Sirlin C; Liver Imaging Group, Department of Radiology, University of California at San Diego, La Jolla, CA., Loomba R; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA.; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2020 Mar; Vol. 71 (3), pp. 849-860. Date of Electronic Publication: 2020 Jan 27.

MRI Assessment of Treatment Response in HIV-associated NAFLD: A Randomized Trial of a Stearoyl-Coenzyme-A-Desaturase-1 Inhibitor (ARRIVE Trial).

Autor: Ajmera VH; NAFLD Research Center, University of California San Diego Health, La Jolla, CA.; Division of Gastroenterology, Department of Medicine, University of California San Diego Health, La Jolla, CA., Cachay E; Division of Infectious Diseases, Owen Clinic, University of California San Diego, San Diego, CA., Ramers C; Family Health Center, San Diego, CA., Vodkin I; Division of Gastroenterology, Department of Medicine, University of California San Diego Health, La Jolla, CA., Bassirian S; NAFLD Research Center, University of California San Diego Health, La Jolla, CA., Singh S; NAFLD Research Center, University of California San Diego Health, La Jolla, CA., Mangla N; NAFLD Research Center, University of California San Diego Health, La Jolla, CA., Bettencourt R; NAFLD Research Center, University of California San Diego Health, La Jolla, CA., Aldous JL; San Ysidro Health, San Diego, CA., Park D; San Ysidro Health, San Diego, CA., Lee D; Division of Infectious Diseases, Owen Clinic, University of California San Diego, San Diego, CA., Blanchard J; Division of Infectious Diseases, Owen Clinic, University of California San Diego, San Diego, CA., Mamidipalli A; Liver Imaging Group, University of California San Diego, La Jolla, CA., Boehringer A; Liver Imaging Group, University of California San Diego, La Jolla, CA., Aslam S; Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA., Leinhard OD; AMRA Medical AB, Linköping, Sweden.; Department of Medical and Health Sciences, Linköping University, Linköping, Sweden., Richards L; NAFLD Research Center, University of California San Diego Health, La Jolla, CA., Sirlin C; Liver Imaging Group, University of California San Diego, La Jolla, CA., Loomba R; NAFLD Research Center, University of California San Diego Health, La Jolla, CA.; Division of Gastroenterology, Department of Medicine, University of California San Diego Health, La Jolla, CA.; Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2019 Nov; Vol. 70 (5), pp. 1531-1545. Date of Electronic Publication: 2019 Jun 18.