Diffuse pediatric high-grade glioma of methylation-based RTK2A and RTK2B subclasses present distinct radiological and histomolecular features including Gliomatosis cerebri phenotype.

Autor: Tauziède-Espariat A; Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.; Inserm, UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France. a.tauziede-espariat@ghu-paris.fr., Friker LL; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Nussbaumer G; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Bison B; Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Neuroradiological Reference Center for the Pediatric Brain Tumor (HIT) Studies of the German Society of Pediatric Oncology and Hematology, Faculty of Medicine, University Augsburg, Augsburg, Germany., Dangouloff-Ros V; Pediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP, Paris, France.; Université Paris Cité, UMR 1163, Institut Imagine and INSERM U1299, Paris, France., Métais A; Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.; Inserm, UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France., Sumerauer D; Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic., Zamecnik J; Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic., Benesch M; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Perwein T; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., van Vuurden D; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Wesseling P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, Amsterdam UMC, Amsterdam, The Netherlands., La Madrid AM; Pediatric Neuro-Oncology, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain., Garrè ML; Neuro-Oncology Unit, IRCSS Istituto Giannina Gaslini, Genoa, Italy., Antonelli M; Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University, Rome, Italy., Giangaspero F; Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University, Rome, Italy., Pietsch T; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Sturm D; Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany., Jones DTW; Division of Pediatric Glioma Research, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Pfister SM; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany., Grabovska Y; Division of Molecular Pathology, Institute of Cancer Research, London, UK., Mackay A; Division of Molecular Pathology, Institute of Cancer Research, London, UK., Jones C; Division of Molecular Pathology, Institute of Cancer Research, London, UK., Grill J; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Ajlil Y; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., von Bueren AO; Department of Pediatrics, Obstetrics and Gynecology, Division of Pediatric Hematology and Oncology, University Hospital Geneva, Geneva, Switzerland.; Cancer Research Platform for Pediatric Oncology and Hematology, Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland., Karremann M; Department of Pediatric and Adolescent Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany., Hoffmann M; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Kramm CM; Division of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany., Kwiecien R; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany., Castel D; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Gielen GH; Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany., Varlet P; Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 1, Rue Cabanis, 75014, Paris, France.; Inserm, UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Nov 18; Vol. 12 (1), pp. 176. Date of Electronic Publication: 2024 Nov 18.

Atrx loss as a promising screening tool for the identification of diffuse midline glioma subtype, H3K27/MAPKinase co-altered.

Autor: Tauziède-Espariat A; GHU Paris Psychiatrie Neurosciences, Department of Neuropathology, Sainte-Anne Hospital, 1, rue Cabanis, Paris, 75014, France. a.tauziede-espariat@ghu-paris.fr.; Paris University France, Paris, 75006, France. a.tauziede-espariat@ghu-paris.fr., Castel D; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris- Saclay, Villejuif, 94805, France.; Univ. Evry, Université Paris-Saclay, Evry, 91000, France., Ajlil Y; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris- Saclay, Villejuif, 94805, France., Auffret L; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris- Saclay, Villejuif, 94805, France.; Univ. Evry, Université Paris-Saclay, Evry, 91000, France., Appay R; Department of Pathology, APHM La Timone, Marseille, France., Mariet C; GHU Paris Psychiatrie Neurosciences, Department of Neuropathology, Sainte-Anne Hospital, 1, rue Cabanis, Paris, 75014, France., Hasty L; GHU Paris Psychiatrie Neurosciences, Department of Neuropathology, Sainte-Anne Hospital, 1, rue Cabanis, Paris, 75014, France., Métais A; GHU Paris Psychiatrie Neurosciences, Department of Neuropathology, Sainte-Anne Hospital, 1, rue Cabanis, Paris, 75014, France.; Paris University France, Paris, 75006, France., Chrétien F; GHU Paris Psychiatrie Neurosciences, Department of Neuropathology, Sainte-Anne Hospital, 1, rue Cabanis, Paris, 75014, France.; Paris University France, Paris, 75006, France., Grill J; Paris University France, Paris, 75006, France.; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris- Saclay, Villejuif, 94805, France.; Department of Pediatric Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, 94805, France., Varlet P; GHU Paris Psychiatrie Neurosciences, Department of Neuropathology, Sainte-Anne Hospital, 1, rue Cabanis, Paris, 75014, France.; Paris University France, Paris, 75006, France.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jun 27; Vol. 12 (1), pp. 105. Date of Electronic Publication: 2024 Jun 27.

"Hemispheric pilocytic astrocytoma" revisited: A comprehensive clinicopathological and molecular series emphasizing their overlap with other glioneuronal tumors.

Autor: Mariet C; Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, Paris, France.; Department of Pediatric Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Grill J; Department of Pediatric Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Ajlil Y; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Department of Child and Adolescent Oncology, Gustave Roussy, Villejuif, France., Castel D; U981, Molecular Predictors and New Targets in Oncology, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Department of Child and Adolescent Oncology, Gustave Roussy, Villejuif, France., Dangouloff-Ros V; Pediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP, Paris, France.; Department UMR 1163, Institut Imagine and INSERM U1299, Université Paris Cité, Paris, France., Boddaert N; Pediatric Radiology Department, Hôpital Necker Enfants Malades, AP-HP, Paris, France.; Department UMR 1163, Institut Imagine and INSERM U1299, Université Paris Cité, Paris, France., Meurgey A; Department of Biopathology, Léon Bérard Cancer Center, Lyon, France.; Department CNRS 5286, INSERM 1052, Cancer Research Center of Lyon (CRCL), Lyon, France., Pissaloux D; Department of Biopathology, Léon Bérard Cancer Center, Lyon, France.; Department CNRS 5286, INSERM 1052, Cancer Research Center of Lyon (CRCL), Lyon, France., Appay R; Department of Pathology and Neuropathology, APHM, CHU Timone, Marseille, France.; Institute of Neurophysiopathol, CNRS, INP, Aix-Marseille University, Marseille, France., Saffroy R; Department of Biochemistry and Oncogenetic, Paul Brousse Hospital, Villejuif, France., Puget S; Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite, Paris, France.; Department of Neurosurgery, CHU Martinique, Fort-de-France, France., Blauwblomme T; Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite, Paris, France., Beccaria K; Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Sorbonne Paris Cite, Paris, France., Hasty L; Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, Paris, France., Rigau V; Department of Pathology, Gui de Chauliac Hospital, Montpellier, France., Roujeau T; Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier, France., Aline-Fardin A; Department of Pathology, CHU Martinique, Fort-de-France, France., Chrétien F; Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Ima-Brain Team, INSERM U1266, Université Paris Cité, Paris, France., Métais A; Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Ima-Brain Team, INSERM U1266, Université Paris Cité, Paris, France., Varlet P; Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Ima-Brain Team, INSERM U1266, Université Paris Cité, Paris, France., Tauziède-Espariat A; Department of Neuropathology, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, Paris, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), Ima-Brain Team, INSERM U1266, Université Paris Cité, Paris, France.

Publikováno v: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2024 Jan 19; Vol. 83 (2), pp. 115-124.

VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells.

Autor: Menez V; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Kergrohen T; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Shasha T; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Silva-Evangelista C; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Le Dret L; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Auffret L; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Subecz C; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Lancien M; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Ajlil Y; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Vilchis IS; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Beccaria K; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Department of Pediatric Neurosurgery, Necker Enfants Malades, Paris, France., Blauwblomme T; Department of Pediatric Neurosurgery, Necker Enfants Malades, Paris, France., Oberlin E; Inserm UMRS-MD 1197, Université Paris-Saclay, Villejuif, France., Grill J; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Département de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Castel D; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Debily MA; U981, Molecular Predictors and New Targets in Oncology, Team Genomics and Oncogenesis of Pediatric Brain Tumors, INSERM, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Univ Evry, Université Paris-Saclay, Evry, France.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Oct 10; Vol. 13, pp. 1229312. Date of Electronic Publication: 2023 Oct 10 (Print Publication: 2023).

Pediatric spinal pilocytic astrocytomas form a distinct epigenetic subclass from pilocytic astrocytomas of other locations and diffuse leptomeningeal glioneuronal tumours.

Autor: Métais A; Service de Neuropathologie, GHU Psychiatrie et Neurosciences, Site Sainte-Anne, 1 Rue Cabanis, 75014, Paris, France. a.metais@ghu-paris.fr.; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Université de Paris, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), 102-108 rue de la Santé, 75014, Paris, France. a.metais@ghu-paris.fr., Bouchoucha Y; SIREDO Center (Care, Innovation and Research for Children, Adolescents and Young Adults), Institut Curie, Paris, France.; Université Paris-Cité, Paris, France., Kergrohen T; Team Genomics and Oncogenesis of Pediatric Brain Tumors, Molecular Predictors and New Targets in Oncology, INSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Dangouloff-Ros V; Pediatric Radiology Department, AP-HP, Hôpital Necker Enfants Malades, Université Paris Cité, Institut Imagine INSERM U1163, 75015, Paris, France., Maynadier X; Department of Biostatistics, Institut Curie, PSL University, Paris, France., Ajlil Y; Team Genomics and Oncogenesis of Pediatric Brain Tumors, Molecular Predictors and New Targets in Oncology, INSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Carton M; Department of Biostatistics, Institut Curie, PSL University, Paris, France., Yacoub W; Pediatric Radiology Department, AP-HP, Hôpital Necker Enfants Malades, Université Paris Cité, Institut Imagine INSERM U1163, 75015, Paris, France., Saffroy R; Department of Biochemistry and Oncogenetic, Paul-Brousse Hospital, Villejuif, France., Figarella-Branger D; Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France., Uro-Coste E; Département d'anatomie et Cytologie Pathologiques, CHU de Toulouse, IUCT-Oncopole, Toulouse, France., Sevely A; Department of Radiology, Toulouse University Hospital, Toulouse, France., Larrieu-Ciron D; Department of Neurology, Toulouse University Hospital, Toulouse, France.; Department of Medical Oncology, IUCT-Oncopole, Toulouse, France., Faisant M; Department of Pathology, CHU Caen, Caen, France., Machet MC; Department of Pathology, CHRU Bretonneau, Tours, France., Wahler E; Service de Neuropathologie, GHU Psychiatrie et Neurosciences, Site Sainte-Anne, 1 Rue Cabanis, 75014, Paris, France., Roux A; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Université de Paris, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), 102-108 rue de la Santé, 75014, Paris, France.; Department of Neurosurgery, GHU Paris-Psychiatrie et Neurosciences Sainte-Anne Hospital, Paris, France., Benichi S; Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris-Université Paris Cité, Paris, France., Beccaria K; Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris-Université Paris Cité, Paris, France., Blauwblomme T; Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris-Université Paris Cité, Paris, France., Boddaert N; Pediatric Radiology Department, AP-HP, Hôpital Necker Enfants Malades, Université Paris Cité, Institut Imagine INSERM U1163, 75015, Paris, France., Chrétien F; Service de Neuropathologie, GHU Psychiatrie et Neurosciences, Site Sainte-Anne, 1 Rue Cabanis, 75014, Paris, France., Doz F; SIREDO Center (Care, Innovation and Research for Children, Adolescents and Young Adults), Institut Curie, Paris, France.; Université Paris-Cité, Paris, France., Dufour C; Département de Cancérologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France., Grill J; Département de Cancérologie de l'Enfant et de l'Adolescent, Institut Gustave Roussy, Université Paris-Sud, Villejuif, France., Debily MA; Team Genomics and Oncogenesis of Pediatric Brain Tumors, Molecular Predictors and New Targets in Oncology, INSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.; Univ. Evry, Université Paris-Saclay, Evry, France., Varlet P; Service de Neuropathologie, GHU Psychiatrie et Neurosciences, Site Sainte-Anne, 1 Rue Cabanis, 75014, Paris, France.; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Université de Paris, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), 102-108 rue de la Santé, 75014, Paris, France., Tauziède-Espariat A; Service de Neuropathologie, GHU Psychiatrie et Neurosciences, Site Sainte-Anne, 1 Rue Cabanis, 75014, Paris, France.; Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, INSERM, Université de Paris, Equipe IMA-BRAIN (Imaging Biomarkers for Brain Development and Disorders), 102-108 rue de la Santé, 75014, Paris, France.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2023 Jan; Vol. 145 (1), pp. 83-95. Date of Electronic Publication: 2022 Oct 20.