Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ajitha, Thanabalasuriar"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Resident macrophages play a unique role in the maintenance of tissue function. As phagocytes, they are an essential first line defenders against pathogens and much of the initial characterization of these cells was focused on their interaction with v
Externí odkaz:
https://doaj.org/article/1f0518ac02104f63bdf4e8237c724009
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3260-3272 (2016)
iNKT cells are a subset of innate T cells that recognize glycolipids presented on CD1d molecules and protect against bacterial infections, including S. pneumoniae. Using lung intravital imaging, we examined the behavior and mechanism of pulmonary iNK
Externí odkaz:
https://doaj.org/article/0a581b2694a64ae18309ee5a84e70a9f
Publikováno v:
WIREs Mechanisms of Disease. 14
In a world filled with microbes, some posing a threat to our body, our immune system is key to living a healthy life. The innate immune system is made of various cell types that act to guard our bodies. Unlike the adaptive immune system that has a sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164be8aa821ca34ae10c5e9bc6f94aa5
https://doi.org/10.1002/wsbm.1567
https://doi.org/10.1002/wsbm.1567
Autor:
Erwan Pernet, Sarah Sun, Nicole Sarden, Saideep Gona, Angela Nguyen, Nargis Khan, Martin Mawhinney, Kim A. Tran, Julia Chronopoulos, Dnyandeo Amberkar, Mina Sadeghi, Alexandre Grant, Shradha Wali, Renaud Prevel, Jun Ding, James G. Martin, Ajitha Thanabalasuriar, Bryan G. Yipp, Luis B. Barreiro, Maziar Divangahi
Publikováno v:
Nature.
Resident-tissue macrophages (RTMs) arise from embryonic precursors1,2, yet the developmental signals that shape their longevity remain largely unknown. Here we demonstrate in mice genetically deficient in 12-lipoxygenase and 15-lipoxygenase (Alox15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f65fb724b0e5e8255811c947c9d7102
https://pubmed.ncbi.nlm.nih.gov/36599368
https://pubmed.ncbi.nlm.nih.gov/36599368
Publikováno v:
Journal of Leukocyte Biology
It has long been appreciated that understanding the interactions between the host and the pathogens that make us sick is critical for the prevention and treatment of disease. As antibiotics become increasingly ineffective, targeting the host and spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b1fd7a3ef0579bc8c3e3ac9b91c7d4
https://doi.org/10.1002/jlb.4ri1218-503r
https://doi.org/10.1002/jlb.4ri1218-503r
Autor:
Adem C. Koksal, Chelsea C. Boo, Margarita Camara, Lily Cheng, Nicholas Holoweckyj, Virginia N. Takahashi, Carolina S. Caceres, Andriani C. Patera, Antonio DiGiandomenico, Christopher Morehouse, Shonda Hawkins, Taylor S. Cohen, Melissa de los Reyes, Ashley E. Keller, Bret R. Sellman, Sonja Hess, Mark Pelletier, Ajitha Thanabalasuriar, Marcello Marelli, Abby J. Chiang, Aaron A Berlin
Publikováno v:
Science Advances. 7
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury. These neutrophils expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302b619adf0ba39ca10d865184c5e43f
https://doi.org/10.1126/sciadv.abd9436
https://doi.org/10.1126/sciadv.abd9436
Publikováno v:
The international journal of biochemistrycell biology. 134
As we learn more about chronic lung diseases, we are seeing that an unbalanced immune system plays a key role in disease pathogenesis. Innate immune cells, particularly tissue-resident macrophages, are important navigators of immunity, both during in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce061891218faf54673209989c89f42e
https://pubmed.ncbi.nlm.nih.gov/33677070
https://pubmed.ncbi.nlm.nih.gov/33677070
Autor:
Ajitha, Thanabalasuriar, Abby J, Chiang, Christopher, Morehouse, Margarita, Camara, Shonda, Hawkins, Ashley E, Keller, Adem C, Koksal, Carolina S, Caceres, Aaron A, Berlin, Nicholas, Holoweckyj, Virginia N, Takahashi, Lily, Cheng, Melissa, de Los Reyes, Mark, Pelletier, Andriani C, Patera, Bret, Sellman, Sonja, Hess, Marcello, Marelli, Chelsea C, Boo, Taylor S, Cohen, Antonio, DiGiandomenico
Publikováno v:
Science Advances
Neutrophils abandon infection control during wound repair.
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dadb20c85d74981819d8a619237afbcb
https://pubmed.ncbi.nlm.nih.gov/33674305
https://pubmed.ncbi.nlm.nih.gov/33674305
Autor:
Charles K. Stover, George Wilson, Ajitha Thanabalasuriar, Antonio DiGiandomenico, Bas G.J. Surewaard, Paul Kubes, Michelle Elizabeth Willson, Arpan Sharma Neupane, Ashley E. Keller, Bret R. Sellman, Paul Warrener
Publikováno v:
Journal of Clinical Investigation. 127:2249-2261
Pseudomonas aeruginosa is a major cause of severe infections that lead to bacteremia and high patient mortality. P. aeruginosa has evolved numerous evasion and subversion mechanisms that work in concert to overcome immune recognition and effector fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be5275ac73559437de02a369ff3003c
https://doi.org/10.1172/jci89652
https://doi.org/10.1172/jci89652
Autor:
Matthias Amrein, Moritz Peiseler, Agostina Carestia, Margaret M. Kelly, Arpan Sharma Neupane, Ashley E. Keller, Fernanda Vargas E Silva Castanheira, Paul Kubes, Craig N. Jenne, Antonio DiGiandomenico, Ajitha Thanabalasuriar, Michelle Elizabeth Willson, Andrew Chojnacki, Christopher Morehouse
Publikováno v:
Cell. 183(1)
Summary During respiration, humans breathe in more than 10,000 liters of non-sterile air daily, allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar macrophages (AMs), which favors alveoli devoid of AMs. If AMs, like m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce3cbf626f12b5820d4691e6ec74de0
https://pubmed.ncbi.nlm.nih.gov/32888431
https://pubmed.ncbi.nlm.nih.gov/32888431