Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ajith Welihinda"'
Autor:
Shruti Yadav, Ajith Welihinda, Jordan Mechanic, Manmeet Kaur, Gyeoung Jin Kang, Edward P. Amento, Puja Ravikumar
Publikováno v:
Journal of Investigative Dermatology. 142:624-632.e6
Psoriasis is an immune cell‒mediated inflammatory disease of the skin with a mixed T helper type 1/T helper type17 cytokine environment combined with an innate immune response engaging toll-like receptors. Inflammatory diseases are characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d421ae5c28c7d3917cc8f933bfb04a07
https://doi.org/10.1016/j.jid.2021.07.174
https://doi.org/10.1016/j.jid.2021.07.174
Publikováno v:
Cellular Signalling. 42:227-235
Inosine is an endogenous nucleoside that is produced by metabolic deamination of adenosine. Inosine is metabolically more stable (half-life 15h) than adenosine (half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6cf1ff5eede6956ecb660b98992d27a
https://doi.org/10.1016/j.cellsig.2017.11.002
https://doi.org/10.1016/j.cellsig.2017.11.002
Autor:
Ajith Welihinda, Geoff E Stilwell, Wenbin Zhang, Xiaoyan Li, Haifeng Ding, Yuan-Di C. Halvorsen, Yuan Lu
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(5)
Bexagliflozin is a C-aryl glucoside inhibitor of human sodium-glucose linked transporter 2 (SGLT2) that undergoes oxidation and glucuronidation to form six principal metabolites in humans.In vitro metabolism by human liver microsomes and recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5439c04cc2de478edca562d68f73ab1e
https://pubmed.ncbi.nlm.nih.gov/31432741
https://pubmed.ncbi.nlm.nih.gov/31432741
Publikováno v:
Cellular Signalling. 28:552-560
Inosine is an endogenous purine nucleoside that is produced by catabolism of adenosine. Adenosine has a short half-life (approximately 10 s) and is rapidly deaminated to inosine, a stable metabolite with a half-life of approximately 15 h. Resembling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0d37e05ea23e4c8d76094166ec674
https://doi.org/10.1016/j.cellsig.2016.02.010
https://doi.org/10.1016/j.cellsig.2016.02.010
Publikováno v:
Journal of Investigative Dermatology. 140:S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f2251758239462e3eaec94ad10cea3
https://doi.org/10.1016/j.jid.2020.03.091
https://doi.org/10.1016/j.jid.2020.03.091
Publikováno v:
ChemMedChem. 12(16)
Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine. Nevertheless, recent studies have demonstrated that inosine has neuroprotective, cardiopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62f37b1ed30c46784bb8b18b65e63fd1
https://pubmed.ncbi.nlm.nih.gov/28517175
https://pubmed.ncbi.nlm.nih.gov/28517175
Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine. Nevertheless, recent studies have demonstrated that inosine has neuroprotective, cardiopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083ac8e379407690ae35ea7249ac5560
http://hdl.handle.net/11577/3253212
http://hdl.handle.net/11577/3253212
Autor:
Zhongping Deng, Jacques Y. Roberge, Ge Xu, Kun Peng, Jiajia Dong, Wenbin Zhang, Baihua Xu, Zelin Sheng, Binhua Lv, Yuanwei Chen, Xinxing Tang, Min Xu, Xun Sun, Ajith Welihinda, Yan Feng, Liangcheng Zhu, Jiyan Du, Wei Fu, Lili Zhang
Publikováno v:
Journal of Medicinal Chemistry. 57:1236-1251
SGLT2 inhibitors deuterated at sites susceptible to oxidative metabolism were found to have a slightly longer tmax and half-life (t1/2), dose-dependent increase in urinary glucose excretion (UGE) in rats, and slightly superior effects on UGE in dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ba1e99254e6cdc76b612aa9e63796d
https://doi.org/10.1021/jm401780b
https://doi.org/10.1021/jm401780b
Publikováno v:
Journal of Investigative Dermatology. 139:S121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dfed1ea7acc3264bd9e324a78b78910
https://doi.org/10.1016/j.jid.2019.03.783
https://doi.org/10.1016/j.jid.2019.03.783
Publikováno v:
Journal of Investigative Dermatology. 137:S119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3faac7e83e4dd96ef250b85eb9c1ec37
https://doi.org/10.1016/j.jid.2017.02.713
https://doi.org/10.1016/j.jid.2017.02.713