Výsledky vyhledávání - "Ajit Shankar, Singh"

Reduction of the Double Bond of 6‑Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model

Autor: Dinesh Kumar Yadav, Sunil K. Puri, Ved Prakash Verma, Chandan Singh, Mohammad Hassam, Ajit Shankar Singh

Publikováno v: ACS Omega, Vol 6, Iss 45, Pp 30790-30799 (2021)

Novel 6-arylethyl-1,2,4-trioxanes6a-i and 7a-i are easily accessible in one step from the diimide reduction of 6-arylvinyl-1,2,4-trioxanes 5a-i. All of these new trioxanes were assessed for their oral antimalarial activity against multidrug-resistant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2df7e253a32eb30c75271a10d56760e
https://doaj.org/article/21fbb120c97a4ebaa98abcdde1a23d2e

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Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug

Autor: Akriti Kumari, Manvika Karnatak, Ajit Shankar Singh, Mohammad Hassam, Varun Rawat, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Mandeep Singh, Ved Prakash Verma

Publikováno v: ACS omega. 7(21)

A mechanistic approach to understand the course of metabolism for synthetic 1,2,4-trioxanes, potent antimalarial compounds, to evaluate their bioavailability for antimalarial action has been studied in the present work. It is an important parameter t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3862b2d3bbfde833234745ba720deb
https://pubmed.ncbi.nlm.nih.gov/35664617

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Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via intramuscular route

Autor: Manvika Karnatak, Mohammad Hassam, Ajit Shankar Singh, Dinesh Kumar Yadav, Chandan Singh, Sunil.K. Puri, Ved Prakash Verma

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 58:128522

Novel hydrazone derivatives 10a-m were prepared from N-Amino-11-azaartemisinin (9) and screened for their antimalarial activity by oral and intramuscular (i.m.) routes against multidrug-resistant Plasmodium yoelii in Swiss mice model. Several of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e8ddb5c61dde21ddbf94b7c516dccd
https://doi.org/10.1016/j.bmcl.2021.128522

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Synthesis and evaluation of catalytic curing behavior of novel nitrile-functionalized benzoxazine for phthalonitrile resins

Autor: Shailendra Kumar Shukla, D. N. Tripathi, Arvind Kumar Pandey, Ajit Shankar Singh, N. Eswara Prasad

Publikováno v: Polymer Bulletin. 75:3781-3800

In the present embodiment, bisphthalonitrile resin has been cured using synthesized novel bisphenyl nitrile-containing benzoxazine (NBZ) vis-a-vis traditional curing agents such as 4-(3′aminophenoxy)diphenyl sulphone (m-DDS) and amino-functionalize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43dca56eef76ba723ffadc91325e2240
https://doi.org/10.1007/s00289-017-2235-4

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New Orally Active Amino- and Hydroxy-Functionalized 11-Azaartemisinins and Their Derivatives with High Order of Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii in Swiss Mice1

Autor: Mohammad Hassam, Ved Prakash Verma, Ajit Shankar Singh, Chandan Singh, Sunil K. Puri, Niraj K. Naikade

Publikováno v: Journal of Medicinal Chemistry. 57:2489-2497

By use of artemisinin 1 as the starting material, two new amino- and hydroxy-functionalized 11-azaartemisinins 9 and 11 and their derivatives 12a-g, 13a-g, 14a-g, and 15a-c have been prepared and screened for antimalarial activity by oral route again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7535da1c49b30cf8e0a19df4a2082856
https://doi.org/10.1021/jm401774f

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Bile Acid-Based 1,2,4-Trioxanes: Synthesis and Antimalarial Assessment

Autor: Niraj K. Naikade, Prakas R. Maulik, Mohammad Hassam, Ruchir Kant, Ved Prakash Verma, Sunil K. Puri, Ajit Shankar Singh, Chandan Singh

Publikováno v: Journal of Medicinal Chemistry. 55:10662-10673

A new series of bile acid-based trioxanes 23a-d, 24a-d, 25a-d, 26a, 26b, and 26d have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. The antimalarial activity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a8b2ff37d9866c4a0cadcbebfeacf2
https://doi.org/10.1021/jm301323k

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Synthesis of silicon-containing bisnadiimide

Autor: Shailendra Kumar Shukla, Ajit Shankar Singh, Sarfaraz Alam

Publikováno v: Journal of Thermal Analysis and Calorimetry. 107:509-517

Silicon-containing thermosetting bisnadiimide (BNI) was synthesized using Bis (amino propyl) tetramethyl disiloxane and nadic anhydride, and fluorine-containing thermoplastic polyamic acid (FPA) was synthesized from 4,4′-(hexafluoroisopropylidene)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92b559370764dde98865dda489a68c69
https://doi.org/10.1007/s10973-011-1783-3

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Hydrazinium Carbazate-H2O2: An Ideal Combination for Diimide Reduction of Base-Sensitive Unsaturated Peroxides¹

Autor: Niraj K. Naikade, Shilpi Pandey, Ved Prakash Verma, Mohammad Hassam, Nitin Gupta, Ajit Shankar Singh, Chandan Singh

Publikováno v: Synthesis. 2010:1014-1022

The utility of a hydrazinium carbazate (N 2 H 3 COON 2 H 5 ) andH 2 O 2 combination for the double bond reductionof base-sensitive unsaturated 1,2,4-trioxanes, 1,2,4-trioxepanes,and their precursors β- and γ-hydroxyhydroperoxidesis presented. The m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddf2d7ff4b832a96d98298bfb0db40ac
https://doi.org/10.1055/s-0029-1218639

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