Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ajit P Joglekar"'
Publikováno v:
eLife, Vol 9 (2020)
During mitosis, the Spindle Assembly Checkpoint (SAC) maintains genome stability while also ensuring timely anaphase onset. To maintain genome stability, the SAC must be strong to delay anaphase even if just one chromosome is unattached, but for time
Externí odkaz:
https://doaj.org/article/a91b6346ca1946839294df3c851480c7
Autor:
Vikash Verma, Leena Mallik, Rizal F Hariadi, Sivaraj Sivaramakrishnan, Georgios Skiniotis, Ajit P Joglekar
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137125 (2015)
DNA origami provides a versatile platform for conducting 'architecture-function' analysis to determine how the nanoscale organization of multiple copies of a protein component within a multi-protein machine affects its overall function. Such analysis
Externí odkaz:
https://doaj.org/article/4117985bf4ef4fa786ee5e73a8d49432
Autor:
Chu Chen, Valentina Piano, Amal Alex, Simon J. Y. Han, Pim J. Huis in ’t Veld, Babhrubahan Roy, Daniel Fergle, Andrea Musacchio, Ajit P. Joglekar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
The formation of the mitotic checkpoint complex requires an intricate spatial coordination amongst the proteins Bub1, Mad1, Cdc20, and Mad2. Chen et al show that a structural flexibility in Mad1 plays an essential role in achieving this coordination.
Externí odkaz:
https://doaj.org/article/d238c71302b0460b962ca812a2e41935
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Kinetochore (KTs) are macromolecular protein assemblies that attach sister chromatids to spindle microtubules (MTs) and mediate accurate chromosome segregation during mitosis. The outer KT consists of the KMN network, a protein super-complex comprisi
Externí odkaz:
https://doaj.org/article/56c1a387fcf14bb9b601a90474089e51
Autor:
Chu Chen, Lauren Humphrey, Soubhagyalaxmi Jema, Shriya Karmarkar, Frank Ferrari, Ajit P. Joglekar
SummaryDuring mitosis, unattached kinetochores in a dividing cell signal to the Spindle Assembly Checkpoint to delay anaphase onset and prevent chromosome missegregation1–4. The signaling activity of these kinetochores and the likelihood of chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03f502b498d8752acb24a251ead37d59
https://doi.org/10.1101/2022.05.10.491369
https://doi.org/10.1101/2022.05.10.491369
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Open Biology
Open Biology
Kinetochores are macromolecular protein assemblies that attach sister chromatids to spindle microtubules and mediate accurate chromosome segregation during mitosis. The outer kinetochore consists of the KMN network, a protein super-complex comprising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37b531fc033ca6e09319200b65529ee
https://doi.org/10.1098/rsob.210274
https://doi.org/10.1098/rsob.210274
During mitosis, unattached kinetochores in a dividing cell activate the Spindle Assembly Checkpoint (SAC) and delay anaphase onset by generating the anaphase-inhibitory Mitotic Checkpoint Complex (MCC). These kinetochores generate the MCC by recruiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a80af29d213bbc957689bf5dd987b2
https://doi.org/10.1101/2021.08.12.456107
https://doi.org/10.1101/2021.08.12.456107
Publikováno v:
The Journal of Cell Biology
Roy et al. highlight a harmful cross-talk that can arise between spindle assembly checkpoint silencing and chromosome biorientation due to the involvement of protein phosphatase 1 in both the processes.
Accurate chromosome segregation during cel
Accurate chromosome segregation during cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c326a6a268dd32758d68d4eb9fda9beb
http://europepmc.org/articles/PMC6891095
http://europepmc.org/articles/PMC6891095
Publikováno v:
Curr Biol
SummaryAccurate chromosome segregation during cell division requires amphitelic chromosome attachment to the spindle apparatus. It is ensured by the combined activity of the Spindle Assembly Checkpoint1 (SAC), a signaling mechanism that delays anapha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daaa3184373f0985446a4a39d712322
https://doi.org/10.1101/2021.01.05.425459
https://doi.org/10.1101/2021.01.05.425459