Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ajit Kandale"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects li
Externí odkaz:
https://doaj.org/article/3013e09cf1bb4fb3bcfd3869ba7c4bed
Autor:
Luke W. Guddat, Ajit Kandale, Lendl Tan, Gerhard Schenk, Nicholas P. West, Shun Jie Wun, Waleed M. Hussein, Ross P. McGeary, Khushboo M. Patel, Shan Zheng
Publikováno v:
Journal of Medicinal Chemistry. 64:1670-1684
New drugs to treat tuberculosis (TB) are urgently needed to combat the increase in resistance observed among the current first-line and second-line treatments. Here, we propose ketol-acid reductoisomerase (KARI) as a target for anti-TB drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53c21cfcd7fd00c0fed17f2619927f5f
https://doi.org/10.1021/acs.jmedchem.0c01919
https://doi.org/10.1021/acs.jmedchem.0c01919
The kappa opioid receptor (KOPr) has exceptional potential as an analgesic target, seemingly devoid of the many peripheral side-effects of Mu receptors. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02726adb2bd6480e0dd75a86749237aa
https://doi.org/10.22541/au.163940789.98987711/v1
https://doi.org/10.22541/au.163940789.98987711/v1
Autor:
You Lv, Shan Zheng, Adi Goldenzweig, Fengjiang Liu, Yan Gao, Xiuna Yang, Ajit Kandale, Ross P. McGeary, Simon Williams, Bostjan Kobe, Mark A. Schembri, Michael J. Landsberg, Bin Wu, Thomas B. Brück, Volker Sieber, Mikael Boden, Zihe Rao, Sarel J. Fleishman, Gerhard Schenk, Luke W. Guddat
Publikováno v:
Applied Biosciences; Volume 1; Issue 2; Pages: 163-178
The branched-chain amino acids (BCAAs) leucine, isoleucine and valine are synthesized via a common biosynthetic pathway. Ketol-acid reductoisomerase (KARI) is the second enzyme in this pathway. In addition to its role in BCAA biosynthesis, KARI catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cf0a7e7d6df0297b8f241237e34c9e
https://mediatum.ub.tum.de/doc/1689329/document.pdf
https://mediatum.ub.tum.de/doc/1689329/document.pdf
Autor:
Ajit, Kandale, Khushboo, Patel, Waleed M, Hussein, Shun Jie, Wun, Shan, Zheng, Lendl, Tan, Nicholas P, West, Gerhard, Schenk, Luke W, Guddat, Ross P, McGeary
Publikováno v:
Journal of medicinal chemistry. 64(3)
New drugs to treat tuberculosis (TB) are urgently needed to combat the increase in resistance observed among the current first-line and second-line treatments. Here, we propose ketol-acid reductoisomerase (KARI) as a target for anti-TB drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::851f04823dcab4b2bcd2fd149663be3d
https://pubmed.ncbi.nlm.nih.gov/33512163
https://pubmed.ncbi.nlm.nih.gov/33512163
Autor:
Ajit Kandale, Luke W. Guddat, Gerhard Schenk, You Lv, Volker Sieber, Simon J. Williams, Bostjan Kobe, Mark A. Schembri, Ross P. McGeary, Shun Jie Wun
Publikováno v:
The FEBS Journal. 283:1184-1196
The biosynthetic pathway for the branched-chain amino acids is present in plants, fungi and bacteria, but not in animals, making it an attractive target for herbicidal and antimicrobial drug discovery. Ketol-acid reductoisomerase (KARI; EC 1.1.1.86)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed78bf80ee17281921157f0df0d32d1
https://doi.org/10.1111/febs.13672
https://doi.org/10.1111/febs.13672
Autor:
T.N.V. Ganesh Kumar, Jeyaprakash, Ajit Kandale, Jesil Mathew, Suryanarayana Raju D, Rajeev K Singla
Publikováno v:
Indo Global Journal of Pharmaceutical Sciences. :01-05
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5db1d254b5db288b302497f163270ba
https://doi.org/10.35652/igjps.2015.17
https://doi.org/10.35652/igjps.2015.17
Autor:
Shan Zheng, Khushboo M. Patel, Ross P. McGeary, Mark A. Schembri, David Terán, Luke W. Guddat, Ajit Kandale, Gerhard Schenk, You Lv, Mario D. Garcia
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(72)
Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amino acid (BCAA) biosynthesis pathway. Here we describe the first crystal structures of Staphylococcus aureus (Sa) KARI, these in complex with two trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a586c90d501c63c5115472b0519e9d4a
https://pubmed.ncbi.nlm.nih.gov/28975665
https://pubmed.ncbi.nlm.nih.gov/28975665
Publikováno v:
Medicinal Chemistry Research. 23:4491-4499
Novel ester derivatives of 2, 10-dichloro-12H-dibenzo [d,g] 1,3 dioxocin-6-carboxylic acid were synthesized and evaluated for their in vitro human cholesteryl ester transfer protein (CETP) inhibition. Three out of twelve synthesized compounds showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8670d8b107dda1ccaa71de4664dfe88
https://doi.org/10.1007/s00044-014-1021-1
https://doi.org/10.1007/s00044-014-1021-1