Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ajit B. Thakur"'
Synthesis, Chromatographic Purification, and Isolation of Epothilone–Folic Acid Conjugate BMS-753493
Autor:
Riccardo E. Frigerio, Soong-Hoon Kim, Xujin Lu, Wei Wang, Nuria de Mas, Bing-Shiou Yang, Kevin P. Girard, Olav Lyngberg, Zhenrong Guo, Victor W. Rosso, Zerene A. Manaloto, Gokhale Madhushree Yeshwant, Mark S. Bolgar, Luca Parlanti, Ajit B. Thakur, Germano D'arasmo, Konstantinos Dambalas, Guido Ströhlein
Publikováno v:
Organic Process Research & Development. 15:797-809
We describe the synthesis, chromatographic purification, and isolation of the epothilone–folic acid conjugate BMS-753493, an investigational new drug candidate for the treatment of cancer. The main challenges for process development were the instab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d3c637efff9ba0e17b0eb1f0c1485d
https://doi.org/10.1021/op200023g
https://doi.org/10.1021/op200023g
Publikováno v:
Pharmaceutical Development and Technology. 15:266-275
PEGylated poly(carboxylic acid)s, PEG-b-PCAs, were evaluated as additives for solubilized oral formulations of weakly acidic compounds. Micelles of poly(ethylene glycol)-block-poly(acrylic acid), PEG-b-PAA, and poly(ethylene glycol)-block-poly(methac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af40917af0f81167fcbef56782c1a5c
https://doi.org/10.3109/10837450903170772
https://doi.org/10.3109/10837450903170772
Publikováno v:
Drug development and industrial pharmacy. 39(9)
BMS-753493 is a folate-targeted candidate being developed for the treatment of cancer. As part of preformulation efforts, our aim was twofold - to understand the major degradation pathways and, study its kinetics of degradation to aid drug product de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4d8b6a4529f4fa7dbf9e497dd71264
https://pubmed.ncbi.nlm.nih.gov/23039020
https://pubmed.ncbi.nlm.nih.gov/23039020
Autor:
Ciro J. Spagnuolo, Abu T.M. Serajuddin, Michael G. Fakes, Ann Newman, Kenneth R. Morris, John J. Venit, Ambarish K. Singh, Ajit B. Thakur
Publikováno v:
International Journal of Pharmaceutics. 105:209-217
A general method was developed to select the optimal salt form for BMS-180431, a novel HMG-CoA reductase inhibitor and a candidate for oral dosage form development, in an expeditious manner at the onset of the drug development process. The physicoche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0514db8ccc4b3c3451c35cbd4ec780c4
https://doi.org/10.1016/0378-5173(94)90104-x
https://doi.org/10.1016/0378-5173(94)90104-x
Autor:
Otilia May Yue Koo, Barry J. Scheer, Haitao Yang, Ajit B. Thakur, Faranak Nikfar, John D. Fiske, Monica L. Adams
Poly(vinyl alcohol) (PVA)-based formulations are used for pharmaceutical tablet coating with numerous advantages. Our objective is to study the stability of PVA-based coating films in the presence of acidic additives, alkaline additives, and various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10d48125c7c6e6f9b7d79e59b919856
https://europepmc.org/articles/PMC3134661/
https://europepmc.org/articles/PMC3134661/
Autor:
Ajit B. Thakur, Jerzewski Rl, Jens T. Carstensen, Grosso Ja, Wadke Da, Morris K, Thottathil Jk, Himes K
Publikováno v:
Pharmaceutical Research. 10:800-809
Fosinopril sodium (I), a new angiotensin converting enzyme inhibitor, is a diester prodrug of the active moiety II. We report here a novel transformation of fosinopril into β-ketoamide, III, and a phosphonic acid, IV, mediated through metal ion part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0aa724251c375578d39b89a02447d4
https://doi.org/10.1023/a:1018940623174
https://doi.org/10.1023/a:1018940623174
Autor:
Varia Sailesh Amilal, Charles S. Clow, Marilia M. Faustino, Abu T.M. Serajuddin, Ajit B. Thakur
Publikováno v:
Journal of Pharmaceutical Sciences. 80:872-875
Physicochemical factors involved in the development of a topical solution of a novel corticosteroid, tipredane (1), are described. A cosolvent system consisting of polyethylene glycol 400 (PEG 400), propylene glycol, and water was used to dissolve th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c135e27e1b7c8ffe1fcbfb9d64db003b
https://doi.org/10.1002/jps.2600800914
https://doi.org/10.1002/jps.2600800914
Publikováno v:
Pharmaceutical Research. :1424-1429
The mechanism of possible incompatibility between commercially available metronidazole parenteral solutions and the injectable aztreonam leading to the development of pink color in their intravenous admixtures was studied. It was demonstrated that ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a66ab01647a5d1e78d6af35cddf87c7
https://doi.org/10.1023/a:1015861425746
https://doi.org/10.1023/a:1015861425746
Publikováno v:
Pharmaceutical research. 25(5)
To investigate the effect of polymer additives on the transformation of BMS-566394 anhydrate to the dihydrate form and to propose the possible mechanisms for inhibition of conversion of the anhydrate to the dihydrate form. The conversion of anhydrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61191f55e620e7f120f582b528fccd3c
https://pubmed.ncbi.nlm.nih.gov/17932729
https://pubmed.ncbi.nlm.nih.gov/17932729
Publikováno v:
Pharmaceutical research. 22(2)
To study the oxidative degradation of drugs using a hydrophilic free radical initiator, 2,2′-Azobis(-amidinopropane) dihydrochloride (AAPH). AAPH was used as the free radical initiator to study oxidation of three model compounds (A, B, and C), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d082e12e814e939b4ff5779c9e436944
https://pubmed.ncbi.nlm.nih.gov/15783080
https://pubmed.ncbi.nlm.nih.gov/15783080