Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ajit K. Parhi"'
Autor:
Yongzheng Zhang, Jesus D. Rosado-Lugo, Pratik Datta, Yangsheng Sun, Yanlu Cao, Anamika Banerjee, Yi Yuan, Ajit K. Parhi
Publikováno v:
Antibiotics, Vol 11, Iss 6, p 716 (2022)
Efflux pumps in Gram-negative bacteria such as Pseudomonas aeruginosa provide intrinsic antimicrobial resistance by facilitating the extrusion of a wide range of antimicrobials. Approaches for combating efflux-mediated multidrug resistance involve, i
Externí odkaz:
https://doaj.org/article/cc60c3c1b8bb45ecb9cfd0329a1a77ec
Autor:
Eric J. Bryan, Hye Yeon Sagong, Ajit K. Parhi, Mark C. Grier, Jacques Y. Roberge, Edmond J. LaVoie, Daniel S. Pilch
Publikováno v:
Antibiotics, Vol 11, Iss 5, p 693 (2022)
The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongaso
Externí odkaz:
https://doaj.org/article/f8ac5228aca5430cb41dd1a89b48c18b
Autor:
Yi Yuan, Jesus D. Rosado-Lugo, Yongzheng Zhang, Pratik Datta, Yangsheng Sun, Yanlu Cao, Anamika Banerjee, Ajit K. Parhi
Publikováno v:
Antibiotics, Vol 11, Iss 1, p 30 (2021)
The ability to rescue the activity of antimicrobials that are no longer effective against bacterial pathogens such as Pseudomonas aeruginosa is an attractive strategy to combat antimicrobial drug resistance. Herein, novel efflux pump inhibitors (EPIs
Externí odkaz:
https://doaj.org/article/46998e2c549648709b36af9e2ace4bbf
Autor:
Malvika Kaul, Edgar Ferrer-González, Lilly Mark, Ajit K. Parhi, Edmond J. LaVoie, Daniel S. Pilch
Publikováno v:
Medicinal Chemistry Research. 31:1705-1715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b85c85a7857c9ea45b7db0127565f33
https://doi.org/10.1007/s00044-022-02960-5
https://doi.org/10.1007/s00044-022-02960-5
Autor:
Hye Yeon Sagong, Jesus D Rosado-Lugo, Eric J Bryan, Edgar Ferrer-Gonzalez, Yiling Wang, Yanlu Cao, Ajit K Parhi, Daniel S Pilch, Edmond Joseph LaVoie
Publikováno v:
Med Chem Res
MreB is a cytoskeleton protein present in rod-shaped bacteria that is both essential for bacterial cell division and highly conserved. Because most Gram (-) bacteria require MreB for cell division, chromosome segregation, cell wall morphogenesis, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5854ebc8273457e1ef7c4896d08af4c
https://europepmc.org/articles/PMC10112653/
https://europepmc.org/articles/PMC10112653/
Autor:
Ajit K Parhi, Yangsheng Sun, Hye-Yeon Sagong, Jesus Rosado-Lugo, Pratik Datta, Yongzheng Zhang, Yi Yuan
S-(3,4-dichlorobenzyl) isothiourea (A22) and mecillinam are the only known antibacterial agents that act on the rod-shape maintenance mechanism of rod-like bacteria. This makes A22 an attractive lead compound for developing antibiotics with novel mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3a5c5dfa686140d5ffb596321259108
https://doi.org/10.21203/rs.3.rs-1862196/v1
https://doi.org/10.21203/rs.3.rs-1862196/v1
Autor:
Jesus D. Rosado-Lugo, Yangsheng Sun, Anamika Banerjee, Yanlu Cao, Pratik Datta, Yongzheng Zhang, Yi Yuan, Ajit K. Parhi
Publikováno v:
The Journal of antibiotics. 75(7)
FtsZ inhibitors represent a new drug class as no drugs using this mode of action (MOA) have been approved by regulators. 3-alkoxy substituted 2,6-difluorobenzamide scaffold is one of the most studied FtsZ inhibitors among which the most promising ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b8a45d0e2d35ef7f37fcce259e2830
https://pubmed.ncbi.nlm.nih.gov/35618784
https://pubmed.ncbi.nlm.nih.gov/35618784
Publikováno v:
Eur J Med Chem
Several studies that have identified agents that potentiate the antimicrobial activity of antibiotics, but there are limited insights into their structure-activity relationships (SAR). The SAR associated with select N-alkylaryl amide derivatives of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2df2a7a1d8bb29109586ff2ac1a81b5
https://pubmed.ncbi.nlm.nih.gov/31173969
https://pubmed.ncbi.nlm.nih.gov/31173969
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:4290-4296
Combination therapy of bacterial infections with synergistic drug partners offers distinct advantages over monotherapy. Among these advantages are (i) a reduction of the drug dose required for efficacy, (ii) a reduced potential for drug-induced toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ab4b734e1c2bc8d2e83edd26cede11
https://doi.org/10.1128/aac.00613-16
https://doi.org/10.1128/aac.00613-16
Autor:
Michaela Madison, Alexander J. Lepak, Ajit K. Parhi, Karen Marchillo, Jamie VanHecker, David R. Andes
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:6568-6574
Antibiotics with novel mechanisms of action are urgently needed. Processes of cellular division are attractive targets for new drug development. FtsZ, an integral protein involved in cell cytokinesis, is a representative example. In the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ade30be7892449b19c4f80a7cd15efe
https://doi.org/10.1128/aac.01464-15
https://doi.org/10.1128/aac.01464-15