Výsledky vyhledávání - "Ajerico del Rosario"

Akademický článek

Rhinovirus-induced VP1-specific Antibodies are Group-specific and Associated With Severity of Respiratory Symptoms

Autor: Katarzyna Niespodziana, Clarissa R. Cabauatan, David J. Jackson, Daniela Gallerano, Belen Trujillo-Torralbo, Ajerico del Rosario, Patrick Mallia, Rudolf Valenta, Sebastian L. Johnston

Publikováno v: EBioMedicine, Vol 2, Iss 1, Pp 64-70 (2015)

Background: Rhinoviruses (RVs) are a major cause of common colds and induce exacerbations of asthma and chronic inflammatory lung diseases. Methods: We expressed and purified recombinant RV coat proteins VP1-4, non-structural proteins as well as N-te

Externí odkaz: https://doaj.org/article/0a72dfcfa2414b30a2df52c9c923c479

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Akademický článek

Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma.

Autor: Nadine Upton, David J Jackson, Alexandra A Nikonova, Suzie Hingley-Wilson, Musa Khaitov, Ajerico Del Rosario, Stephanie Traub, Maria-Belen Trujillo-Torralbo, Max Habibi, Sarah L Elkin, Onn M Kon, Michael R Edwards, Patrick Mallia, Joseph Footitt, Jonathan Macintyre, Luminita A Stanciu, Sebastian L Johnston, Annemarie Sykes

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0183864 (2017)

Rhinovirus infection is associated with the majority of asthma exacerbations. The role of fractalkine in anti-viral (type 1) and pathogenic (type 2) responses to rhinovirus infection in allergic asthma is unknown. To determine whether (1) fractalkine

Externí odkaz: https://doaj.org/article/21afd09e3daf4e9fa9aa5480b0dd39e1

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Akademický článek

TLR3, TLR4 and TLRs7-9 Induced Interferons Are Not Impaired in Airway and Blood Cells in Well Controlled Asthma.

Autor: Annemarie Sykes, Michael R Edwards, Jonathan Macintyre, Ajerico Del Rosario, Vera Gielen, Jennifer Haas, Onn Min Kon, Mark McHale, Sebastian L Johnston

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65921 (2013)

Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown. Virus infection can induce interferon

Externí odkaz: https://doaj.org/article/590b6f872ac64d1fb01a382efde51dad

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Type I conventional dendritic cells relate to disease severity in virus-induced asthma exacerbations

Autor: Aoife, Cameron, Jaideep, Dhariwal, Nadine, Upton, Ismael, Ranz Jimenez, Malte, Paulsen, Ernie, Wong, Maria-Belen, Trujillo-Torralbo, Ajerico, Del Rosario, David J, Jackson, Michael R, Edwards, Sebastian L, Johnston, Ross P, Walton

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 52(4)

Rhinoviruses are the major precipitant of asthma exacerbations and individuals with asthma experience more severe/prolonged rhinovirus infections. Concurrent viral infection and allergen exposure synergistically increase exacerbation risk. Although d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbfdec3655be3ab150dd2afb4f6b5502
https://pubmed.ncbi.nlm.nih.gov/35212067

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Pulmonary innate lymphoid cell responses during rhinovirus-induced asthma exacerbations

Autor: David J. Cousins, Ernie Wong, Trevor T. Hansel, David A. Jackson, Ajerico del Rosario, Eteri Bakhsoliani, Jaideep Dhariwal, Malte Paulsen, Michael R. Edwards, Aoife Cameron, Ross P. Walton, Belen Trujillo-Torralbo, Sebastian L. Johnston

Rationale Type 2 innate lymphoid cells (ILC2s) are significant sources of type 2 cytokines, which are implicated in the pathogenesis of asthma and asthma exacerbations. The role of ILC2s in virus-induced asthma exacerbations is not well-characterized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498121463a7b8682bb4b9fa01c689153
http://hdl.handle.net/10044/1/92512

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M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations

Autor: Sebastian L. Johnston, Anton S. Dvornikov, Rudolf Valenta, A A Nikonova, Stephanie Traub, Dmitriy A. Kudlay, Maria-Belen Trujillo-Torralbo, Rahim Khaitov, Musa Khaitov, David A. Jackson, Luminita A. Stanciu, Ajerico del-Rosario

Publikováno v: EBioMedicine
EBioMedicine, Vol 54, Iss, Pp-(2020)

Background: Macrophages (Mф) can be M1/M2 polarized by Th1/2 signals, respectively. M2-like Mф are thought to be important in asthma pathogenesis, and M1-like in anti-infective immunity, however their roles in virus-induced asthma exacerbations are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf1aedf01bc54bc493efa3dce7b6825
https://pubmed.ncbi.nlm.nih.gov/32279057

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