Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ajenthan Surendranathan"'
Autor:
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105698- (2022)
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral i
Externí odkaz:
https://doaj.org/article/1dfe16a3a9ee479096b69460084cc8ab
Autor:
John T O’Brien, John-Paul Taylor, Alan Thomas, Claire Bamford, Luke Vale, Sarah Hill, Louise Allan, Tracy Finch, Richard McNally, Louise Hayes, Ajenthan Surendranathan, Joseph Kane, Alexandros E Chrysos, Allison Bentley, Sally Barker, James Mason, David Burn, Ian McKeith
Publikováno v:
Programme Grants for Applied Research, Vol 9, Iss 7 (2021)
Background: Lewy body dementia, comprising both dementia with Lewy bodies and Parkinson’s disease dementia, is the second commonest cause of neurodegenerative dementia. Existing evidence suggests that it is underdiagnosed and without a consistent a
Externí odkaz:
https://doaj.org/article/babfa2016f3142709c81cde594a967e9
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 10, Pp 2133-2136 (2019)
Abstract There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as 11C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when th
Externí odkaz:
https://doaj.org/article/170f01c7993f45d1ae7f7e5060aca091
Autor:
Nicolas Nicastro, Elijah Mak, Guy B. Williams, Ajenthan Surendranathan, W Richard Bevan-Jones, Luca Passamonti, Patricia Vàzquez Rodrìguez, Li Su, Robert Arnold, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, James B. Rowe, John T. O'Brien
Publikováno v:
NeuroImage: Clinical, Vol 25, Iss , Pp - (2020)
Dementia with Lewy bodies (DLB) is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer's pathology. Neuroinflammation is also increasingly recognized as a significant contributor to degeneration. We aimed
Externí odkaz:
https://doaj.org/article/849c0de96fee4c9bb848a84cdc801a14
Autor:
Joseph P. M. Kane, Ajenthan Surendranathan, Allison Bentley, Sally A. H. Barker, John-Paul Taylor, Alan J. Thomas, Louise M. Allan, Richard J. McNally, Peter W. James, Ian G. McKeith, David J. Burn, John T. O’Brien
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-8 (2018)
Abstract Background The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studie
Externí odkaz:
https://doaj.org/article/1a25d6ae02c7481ca1be6c6136d9bcd1
Autor:
Elijah Mak, Richard A.I. Bethlehem, Rafael Romero‐Garcia, Simon Cervenka, Timothy Rittman, Silvy Gabel, Ajenthan Surendranathan, Richard W. Bevan‐Jones, Luca Passamonti, Patricia Vázquez Rodríguez, Li Su, Robert Arnold, Guy B. Williams, Young T. Hong, Tim D. Fryer, Franklin I. Aigbirhio, James B. Rowe, John T. O'Brien
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 678-687 (2018)
Abstract Introduction The deposition of neurofibrillary tangles in neurodegenerative disorders is associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across the continuum of Alzheimer's disease (AD) remain uncle
Externí odkaz:
https://doaj.org/article/d3adbe28210e455d801b9f9de18e1e10
Autor:
John T. O'Brien, Negin Holland, Stephen F. Carter, Elijah Mak, Li Su, Maura Malpetti, James B. Rowe, George Savulich, Young T. Hong, Guy B. Williams, Nicolas Nicastro, Ajenthan Surendranathan, Luca Passamonti, Franklin I. Aigbirhio, Tim D. Fryer, P. Simon Jones
Publikováno v:
Neurobiology of Aging
Neurobiology of Aging, Vol. 101 (2021) pp. 172-180
Neurobiology of Aging, Vol. 101 (2021) pp. 172-180
Alzheimer's disease (AD) pathology is frequently observed as a comorbidity in people with dementia with Lewy bodies (DLB). Here, we evaluated the in vivo distribution of tau burden and its influence on the clinical phenotype of DLB. Tau deposition wa
Autor:
John T. O'Brien, Paul C. Donaghy, Maria Angeles Prats-Sedano, Li Su, Alan J. Thomas, Ajenthan Surendranathan, James B. Rowe, George Savulich
Publikováno v:
International Journal of Geriatric Psychiatry
Funder: NIHR Cambridge Biomedical Research Centre
Funder: NIHR Newcastle Biomedical Research Centre
Funder: The Lewy Body Society UK
Funder: Cambridge Centre for Parkinson‐Plus Syndromes Wellcome Trust (103838)
Objectives: Demen
Funder: NIHR Newcastle Biomedical Research Centre
Funder: The Lewy Body Society UK
Funder: Cambridge Centre for Parkinson‐Plus Syndromes Wellcome Trust (103838)
Objectives: Demen
Neuroinflammation in medial temporal regions predicts cognitive decline in dementia with Lewy bodies
Autor:
Maura Malpetti, George Savulich, Elijah Mak, Nicolas Nicastro, P. Simon Jones, Ajenthan Surendranathan, Li Su, Luca Passamonti, Leonidas Chouliaras, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirho, James B. Rowe, John T. O'Brien
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas
Publikováno v:
Neurobiology of disease. 168
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in AD has been extensively researched in recent years, with evidence that chronic peripheral i