The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function.

Autor: Nynke M Kannegieter, Dennis A Hesselink, Marjolein Dieterich, Rens Kraaijeveld, Ajda T Rowshani, Pieter J M Leenen, Carla C Baan

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170806 (2017)

Monocytes and macrophages play key roles in many disease states, including cellular and humoral rejection after solid organ transplantation (SOT). To suppress alloimmunity after SOT, immunosuppressive drug therapy is necessary. However, little is kno

Externí odkaz: https://doaj.org/article/a3ecb11fa489426b88fb4cee439eb565

Differential effects of activated human renal epithelial cells on T-cell migration.

Autor: Martijn W H J Demmers, Carla C Baan, Els van Beelen, Jan N M Ijzermans, Willem Weimar, Ajda T Rowshani

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64916 (2013)

BackgroundRenal tubular epithelial cells (TECs) are one of the main targets of inflammatory insults during interstitial nephritis and kidney transplant rejection. While Th1 cells are know to be essential in the pathogenesis of rejection, the role of

Externí odkaz: https://doaj.org/article/59a040caa4cf46b9b92fe54600e3d07c

Pretransplant Numbers of CD16+ Monocytes as a Novel Biomarker to Predict Acute Rejection After Kidney Transplantation: A Pilot Study

Autor: Carla C. Baan, Dave L. Roelen, Farhad Rezaee, R. Kraaijeveld, Nicolle H.R. Litjens, Luuk B. Hilbrands, Ajda T. Rowshani, T.P.P. van den Bosch, M. C. Clahsen-van Groningen, E W Steyerberg, D Nieboer, J A van Gestel

Publikováno v: American Journal of Transplantation
American Journal of Transplantation, 17(10), 2659-2667. Wiley-Blackwell Publishing Ltd
American Journal of Transplantation, 17(10), 2659-2667
American Journal of Transplantation, 17, 10, pp. 2659-2667
American Journal of Transplantation, 17, 2659-2667

Item does not contain fulltext Acute rejection is one of the major immunological determinants of kidney graft function and survival. Early biomarkers to predict rejection are lacking. Emerging evidence reveals a crucial role for the monocyte/macropha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d217aa484f5ef27a82cc6c949256a4
https://doi.org/10.1111/ajt.14280

A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype-Based With Body-Weight-Based Tacrolimus Dosing After Living Donor Kidney Transplantation

Autor: Rachida Bouamar, Dennis A. Hesselink, Nauras Shuker, Ajda T. Rowshani, Willem Weimar, J. van de Wetering, Carla C. Baan, T. van Gelder, R.H.N. van Schaik, M. C. Clahsen-van Groningen, Jeffrey Damman

Publikováno v: American Journal of Transplantation, 16(7), 2085-2096. Wiley-Blackwell Publishing Ltd
American journal of transplantation, 16(7), 2085-2096. Wiley-Blackwell

Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose to achieve therapeutic exposure compared with nonexpressers. This randomized-controlled study investigated whether adaptation of the tacrolimus starting dose acco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90baa9cb0bc8e78ac1c3a061cae727c2
https://doi.org/10.1111/ajt.13691

Targeting the Monocyte-Macrophage Lineage in Solid Organ Transplantation

Autor: Ajda T. Rowshani, Dennis A. Hesselink, Carla C. Baan, Thierry P P van den Bosch, Nynke M. Kannegieter

Publikováno v: Frontiers in Immunology, 8:153. Frontiers Media S.A.
Frontiers in Immunology

There is an unmet clinical need for immunotherapeutic strategies that specifically target the active immune cells participating in the process of rejection after solid organ transplantation. The monocyte-macrophage cell lineage is increasingly recogn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7cc31e123dbbbcc2433b00eddddc67
https://pure.eur.nl/en/publications/22657514-fb1a-4c89-a9e1-dd8c234372b1