Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ajaykumar Vishwakarma"'
Autor:
Myung-Chul Kim, Nicholas Borcherding, Kawther K. Ahmed, Andrew P. Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N. Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y. Helm, Xin Zhang, Katherine N. Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prog
Externí odkaz:
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
Autor:
Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K. Salem, Russell W. Jenkins, Yousef Zakharia, Weizhou Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Borcherding and Vishwakarma et al. characterize the tumor immune microenvironment in treatment-naïve clear cell renal carcinoma patients using single-cell RNA- and T-cell receptor sequencing. They find CD8 + T cells and macrophages are enriched in t
Externí odkaz:
https://doaj.org/article/69009c376bfa4f7e91c1b591b507d8ed
Autor:
George J Weiner, Aliasger K Salem, Shakoora A Sabree, Andrew P Voigt, Sue E Blackwell, Ajaykumar Vishwakarma, Michael S Chimenti
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background CMP-001, also known as vidutolimod, is a virus-like particle containing a TLR9 agonist that is showing promise in early clinical trials. Our group previously demonstrated that the immunostimulatory effects of CMP-001 are dependent on an an
Externí odkaz:
https://doaj.org/article/4b2849718b58408bbeccee7f317793da
Autor:
Zheng Wang, Dorina Avram, Xin Zhang, Ryan Kolb, Ajaykumar Vishwakarma, Hongrui Xiang, Xuefeng Wu, Xian Huang, Katherine N. Gibson-Corley, Umasankar De, Andrew P. Voigt, Julia Klesney-Tait, Myung-Chul Kim, Dongyang Wang, Song Guo Zheng, Mingjia Li, Rhonda Bacher, Weizhou Zhang, Gaurav Pandey, Nicholas Borcherding, Jiajia Hu, Jian Tang, Haoyang Zhuang, Jinke Cheng, Yuwen Zhu, Daohong Zhou, Jinglu Lu, Theodore T. Drashansky, Paige Kluz, Kawther K. Ahmed, Yousef Zakharia, Zhengting Wang, Hua Liu, Eric Y. Helm, Jinsong Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting tumor-infiltrating (TI) Treg cells has been challenging. Here, using single-cell RNA sequencing of immune ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926e3a2cc612c6ab949c8e15fe695d1c
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
Autor:
Andrew P. Voigt, Andrew M. Bellizzi, Russell W. Jenkins, Aliasger K. Salem, Weizhou Zhang, Nicholas Borcherding, Ajaykumar Vishwakarma, Jacob Kaplan, Yousef Zakharia, Kenneth G. Nepple
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to immunotherapies, despite low tumor mutational burden. To characterize the tumor immune microenvironment of ccRCC, we applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb172097b33d24f2c75817831751d14
https://doi.org/10.1038/s42003-020-01625-6
https://doi.org/10.1038/s42003-020-01625-6
Autor:
Brandon S.J. Davies, Aloysius J. Klingelhutz, Ling-Zhi Liu, Ryan Kolb, Nguan Soon Tan, Yuwen Zhu, Ajaykumar Vishwakarma, Louis Balcziak, Pengcheng Zhu, Fayyaz S. Sutterwala, Bing-Hua Jiang, Nicholas Borcherding, Katherine N. Gibson-Corley, Nicholas L. Bormann, Xian Shen, Zhen Wei Tan, Xin Ge, Francoise A. Gourronc, Weizhou Zhang, Paige Kluz
Publikováno v:
Oncogene
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to the poor clinical outcomes is the suboptimal efficacy of standard therapies due to dose limiting toxicities and obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717931cf92f6aebf5696dda4a37f54b1
http://europepmc.org/articles/PMC6440811
http://europepmc.org/articles/PMC6440811
Autor:
Kenneth G. Nepple, Aliasger K. Salem, Ajaykumar Vishwakarma, Nicholas Borcherding, Purshottam Vishwakarma, Weizhou Zhang, Russell W. Jenkins, Yousef Zakharia, Michael S. Chimenti
The immune cells within the tumor microenvironment are considered key determinants of response to cancer immunotherapy. Immune checkpoint blockade (ICB) has transformed the treatment of clear cell renal cell carcinoma (ccRCC), although the role of sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b47ccc44a46a411a7429af551699a28
https://doi.org/10.1101/824482
https://doi.org/10.1101/824482
Autor:
Mario Moises Alvarez, Ali Khademhosseini, Ajaykumar Vishwakarma, Julie C. Liu, Amir M. Ghaemmaghami, Byung-Hyun Cha, Grissel Trujillo-de Santiago
Publikováno v:
Journal of Controlled Release. 240:349-363
Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed8ce56f5e80f355cd8db40a21341e
https://doi.org/10.1016/j.jconrel.2016.01.026
https://doi.org/10.1016/j.jconrel.2016.01.026
Autor:
Russell W. Jenkins, Purshottam Vishwakarma, Michael S. Chimenti, Aliasger K. Salem, Kenneth G. Nepple, Ajaykumar Vishwakarma, Nick Bocherding, Weizhou Zhang, Yousef Zakharia
Publikováno v:
Cancer Immunology Research. 8:A80-A80
Human clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high levels of tumor-infiltrating immune cells including T cells, yet not every patient responds to immunotherapy. Interestingly, in contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ea9b3b429a624d69cef8eab9a1202c
https://doi.org/10.1158/2326-6074.tumimm19-a80
https://doi.org/10.1158/2326-6074.tumimm19-a80
Autor:
Yuwen Zhu, Xuefeng Wu, Yousef Zakharia, Xian Huang, Song Guo Zheng, Andrew P. Voigt, Weizhou Zhang, Ajaykumar Vishwakarma, Jinsong Lu, Nicholas Borcherding, Gaurav Pandey, Jinke Cheng, Katherine N. Gibson-Corley, Julia Klesney-Tait, Ryan Kolb, Paige Kluz, Kawther K. Ahmed, Jinglu Lu
Regulatory T cells (Tregs) are a population of T cells that exert a suppressive effect on a variety of immune cells and non-immune cells. The suppressive effects of Tregs are detrimental to anti-tumor immunity. Recent investigations into cancer-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2896e9def1c05a4772ad388cdaf0bb2a
https://doi.org/10.1101/478628
https://doi.org/10.1101/478628