Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ajaykumar N. Sharma"'
Autor:
Satyajit Mohite, Fang Yang, Pooja A Amin, Giovana Zunta-Soares, Gabriela D Colpo, Laura Stertz, Ajaykumar N Sharma, Gabriel R Fries, Consuelo Walss-Bass, Jair C Soares, Olaoluwa O Okusaga
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174073 (2017)
Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins. Elevated selectin levels have been report
Externí odkaz:
https://doaj.org/article/a4307fe84ed748e1bc0a93f2fc36031d
Autor:
Laura Stertz, Bianca Wollenhaupt de Aguiar, C. R. Moreira Maia, Ajaykumar N. Sharma, Luis Augusto Rohde, Angélica Salatino-Oliveira, Silzá Tramontina, Flávio Kapczinski, Cristian Patrick Zeni, Mara H. Hutz, Gabriel Ferreira Pheula
Publikováno v:
Acta Psychiatrica Scandinavica. 134:268-274
Objective Frontiers between pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) are not well defined. Few studies have addressed potentially different neurobiological factors between the two disorders. Brain-derived n
Autor:
Juan F. Galvez, André F. Carvalho, João Quevedo, Ajaykumar N. Sharma, Gabriel Rodrigo Fries, Jair C. Soares, Samira S. Valvassori
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 66:22-34
The current pathophysiological understanding of mechanisms leading to onset and progression of bipolar manic episodes remains limited. At the same time, available animal models for mania have limited face, construct, and predictive validities. Additi
Autor:
Marsal Sanches, Juan F. Galvez, Jane E. Hamilton, Isabelle E. Bauer, Benson Mwangi, Giovana Zunta-Soares, João Quevedo, Ajaykumar N. Sharma, Jair C. Soares
Publikováno v:
Medical Hypotheses. 84:285-293
Recent evidence shows an important relationship between metabolic disturbances and bipolar disorder (BD). However, it is still unclear whether such metabolic disturbances are only a consequence or to some extent the precipitating factors for health p
Publikováno v:
Metabolic Brain Disease. 30:719-730
Despite major advances in the understanding about ethanol actions, the precise underlying neurobiological mechanisms for ethanol dependence remain largely elusive. We recently reported that inhibition of dipeptidyl-peptidase IV (DPP-IV), an enzyme re
Autor:
Giovana Zunta-Soares, João Quevedo, Juan F. Galvez, Marsal Sanches, Ajaykumar N. Sharma, Isabelle E. Bauer, Flávio Kapczinski, Jair C. Soares
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 54:289-298
Introduction Bipolar disorder (BD) patients present a 3–5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood. Ob
Publikováno v:
Physiology & Behavior. :38-41
Recent studies indicate a high comorbidity between type-2 diabetes mellitus (T2DM) and neurological disorders. Many are associated with abnormalities in dopamine neurotransmission such as schizophrenia. Because most of the antipsychotic drugs aggrava
Autor:
André F. Carvalho, Bruno Fernando Borges da Costa e Silva, Ajaykumar N. Sharma, João Quevedo, Jair C. Soares
The neurotrophin hypothesis of major depressive disorder (MDD) postulates that this illness results from aberrant neurogenesis in brain regions that regulates emotion and memory. Notwithstanding this theory has primarily implicated BDNF in the neurob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4e8e64680cf54e32606d1b7f2ea028
https://europepmc.org/articles/PMC4837031/
https://europepmc.org/articles/PMC4837031/
Publikováno v:
Journal of Psychopharmacology. 26:724-732
The objective of the present study was to examine the effect of long-term management of insulin resistance and hyperglycemia on neurobehavioral deficits in db/db mice. In this study, 5-week-old db/db and lean control mice were fed with rosiglitazone
Publikováno v:
Physiology & Behavior. 101:381-388
Recent clinical studies indicate neurobehavioral disturbances in type-2 diabetics. However, there is paucity of preclinical research to support this concept. The validity of db/db mouse as an animal model to study type-2 diabetes and related complica