Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Ajay S. Bhatnagar"'
Autor:
Steven G. Silverberg, Evan R. Simpson, Hironobu Sasano, Dean P. Edwards, William R. Miller, Dean B. Evans, Paul Ramage, Thomas J. Anderson, Richard J. Santen, Ajay S. Bhatnagar
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 86:239-244
Intratumoral aromatase is a potential therapeutic target for the treatment of postmenopausal estrogen-dependent breast cancers. Therefore, reliable methods should be developed for routine application for the detection of intratumoral aromatase. A mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873e98ccc433b7858158906a59d12b8f
https://doi.org/10.1016/s0960-0760(03)00363-7
https://doi.org/10.1016/s0960-0760(03)00363-7
Autor:
Hanumanthappa Krishnamurthy, H. N. Krishnamurthy, N. R. Moudgal, Gunapala Shetty, Ajay S. Bhatnagar
Publikováno v:
Steroids. 63:414-420
The role/need for estrogen in regulating testicular function of adult male bonnet monkeys (M. radiata) has been investigated by dosing orally a group of five normal males 2.5 mgs of CGP 47645, a long-acting nonsteroidal aromatase inhibitor (AI), once
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2147a5b3443b9eecf1c27afd9f2a167b
https://doi.org/10.1016/s0039-128x(98)00042-7
https://doi.org/10.1016/s0039-128x(98)00042-7
Autor:
Hilary A. Chaudri, Catherine Royce, Patrick Trunet, Ajay S. Bhatnagar, Franzanne Vreeland, Judy Cooper
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 61:241-245
The aim of endocrine therapy is to reduce the estrogenic stimulus for tumour growth. After failure of tamoxifen — the standard “first-line” hormonotherapy for advanced breast cancer (ABC) — the most frequently prescribed endocrine therapies a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::553ff7d6170d193cf80a593e3ad95839
https://doi.org/10.1016/s0960-0760(97)80018-0
https://doi.org/10.1016/s0960-0760(97)80018-0
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 61:157-166
The availability of CGS 16949A, CGS 20267 and CGP 47645, a series of aromatase inhibitors (AIs) having high specific activity and specificity, made possible this study wherein the need for estrogen (E) for regulating (a) follicular maturation/ovulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f49d5e31c0cbe9d1dae9a2d9c27c4a9e
https://doi.org/10.1016/s0960-0760(97)80008-8
https://doi.org/10.1016/s0960-0760(97)80008-8
Publikováno v:
Acta Oncologica. 35:15-18
Letrozole is a new orally, active, potent, and highly specific non-steroidal aromatase inhibitor. Letrozole is about 200 and 10000 times as potent as aminoglutethimide (AG) in vitro and in vivo, respectively. Letrozole was tested in healthy men and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c07d3b9ab8d5c609f44547b659e567e
https://doi.org/10.3109/02841869609083962
https://doi.org/10.3109/02841869609083962
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 47:161-166
Letrozole (CGS 20267) is a non-steroidal aromatase inhibitor which, at its maximally effective dose of 1 mg/kg p.o., elicits endocrine effects equivalent to those seen after ovariectomy. Adult, female cyclic rats were administered letrozole (1 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2dbe6220d6e7788cc7c492eb429312
https://doi.org/10.1016/0960-0760(93)90070-d
https://doi.org/10.1016/0960-0760(93)90070-d
Publikováno v:
Journal of Medicinal Chemistry. 36:1393-1400
The enantiomers of the potent nonsteroidal inhibitor of aromatase fadrozole hydrochloride 3 have been separated and their absolute configuration determined by X-ray crystallography. On the basis of a molecular modeling comparison of the active enanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4895db6e591aa452c8347964465c7aa4
https://doi.org/10.1021/jm00062a012
https://doi.org/10.1021/jm00062a012
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 44:633-636
The non-steroidal aromatase inhibitor CGS 20,267, at maximally effective doses in non-tumor bearing adult female rats, elicits endocrine effects mimicking those seen after surgical ovariectomy and thus induces a "medical" ovariectomy. We now report o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675e3a8697293a57014587783fd1bc60
https://doi.org/10.1016/0960-0760(93)90270-7
https://doi.org/10.1016/0960-0760(93)90270-7
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 41:785-789
Adrenalectomy blocks the memory-improving effect of piracetam-like compounds in mice. If this blockade is due to the removal of endogenous corticosteroids, replacement therapy with exogenous corticosteroids should reinstate the effects on memory. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81058e1b93dd033427b231d0cafeb6a9
https://doi.org/10.1016/0960-0760(92)90425-i
https://doi.org/10.1016/0960-0760(92)90425-i