Zobrazeno 1 - 10
of 465
pro vyhledávání: '"Ajay Rana"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/e0b2892622554e32a96e4de5a6ae96d7
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/68a5e76238aa47128bae7c4dcc5c749f
Autor:
Kanchan Vishnoi, Rong Ke, Navin Viswakarma, Piush Srivastava, Sandeep Kumar, Subhasis Das, Sunil Kumar Singh, Daniel R. Principe, Ajay Rana, Basabi Rana
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-16 (2022)
Abstract The incidence and mortality of hepatocellular carcinoma (HCC) are on a rise in the Western countries including US, attributed mostly to late detection. Sorafenib has been the first-line FDA-approved drug for advanced unresectable HCC for alm
Externí odkaz:
https://doaj.org/article/3ffdf7ee46924e22ae8d4086e6cc67db
Leukocyte subtyping predicts for treatment failure and poor survival in anal squamous cell carcinoma
Autor:
Daniel R. Principe, Jose L. Cataneo, Kaytlin E. Timbers, Regina M. Koch, Klara Valyi-Nagy, Anders Mellgren, Ajay Rana, Gerald Gantt
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Anal squamous cell carcinoma (SCC) generally carries a favorable prognosis, as most tumors are highly sensitive to standard of care chemoradiation. However, outcomes are poor for the 20–30% of patients who are refractory to this
Externí odkaz:
https://doaj.org/article/1872c77f448f476eb4fec216994be067
Autor:
Daniel R. Principe, Patrick W. Underwood, Sandeep Kumar, Kaytlin E. Timbers, Regina M. Koch, Jose G. Trevino, Hidayatullah G. Munshi, Ajay Rana
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in select immunotherapy regimens shows early promise. Though the TGFβ target SMAD4 is deleted
Externí odkaz:
https://doaj.org/article/588723c078b64673a53deefd38e7bbc1
Autor:
Daniel R. Principe, Patrick W. Underwood, Murray Korc, Jose G. Trevino, Hidayatullah G. Munshi, Ajay Rana
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, with a median survival time of 10-12 months. Clinically, these poor outcomes are attributed to several factors, including late stage at the time of diagnosis impeding resectability, as w
Externí odkaz:
https://doaj.org/article/43d9240e0bb74fa5b227dcc0ba5541f6
Autor:
Stanley Borowicz, Daniel R Principe, Matthew J Dorman, Austin J McHenry, Gautam Sondarva, Sandeep Kumar, Vijayalakshmi Ananthanarayanan, Patricia E Simms, Ashley Hess, Ajay Rana
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252197 (2021)
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Though immune checkpoint inhibitors (ICIs) have revolutionized lung cancer therapy in recent years, there are several factors limiting the therapeutic efficacy
Externí odkaz:
https://doaj.org/article/25fe873de866459c8a595831290f2495
Autor:
Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Matthew Dorman, Subhash C Sinha, Kent Hoskins, Gregory Thatcher, Basabi Rana, Ajay Rana
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The mitogen-activated protein kinases (MAPKs) are important for T cell survival and their effector function. Mixed lineage kinase 3 (MLK3) (MAP3K11) is an upstream regulator of MAP kinases and emerging as a potential candidate for targeted
Externí odkaz:
https://doaj.org/article/a88048066d8f4bf1819a611e152d52ec
Autor:
Sandeep Kumar, Daniel R. Principe, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Basabi Rana, Ajay Rana
Publikováno v:
Pharmaceuticals, Vol 13, Iss 1, p 9 (2020)
Mitogen-activated protein kinase (MAPK) signaling networks serve to regulate a wide range of physiologic and cancer-associated cell processes. For instance, a variety of oncogenic mutations often lead to hyperactivation of MAPK signaling, thereby enh
Externí odkaz:
https://doaj.org/article/1f1be3728a414f328020165017385340
Autor:
David Freeman, Rudy Cedillos, Samantha Choyke, Zana Lukic, Kathleen McGuire, Shauna Marvin, Andrew M Burrage, Stacey Sudholt, Ajay Rana, Christopher O'Connor, Christopher M Wiethoff, Edward M Campbell
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62143 (2013)
α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular m
Externí odkaz:
https://doaj.org/article/41aa07bb8d2b404984b03817f68565d6