Zobrazeno 1 - 10 of 84 pro vyhledávání: '"Ajay Madan"'
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Akademický článek
Comparative Evaluation of the Effect of Menstruation, Pregnancy and Menopause on Salivary Flow Rate, pH and Gustatory Function
Autor: Pulin Saluja, Vishwaprakash Shetty, Aparna Dave, Manpreet Arora, Vibha Hans, Ajay Madan
Publikováno v: Journal of Clinical and Diagnostic Research, Vol 8, Iss 10, Pp ZC81-ZC85 (2014)
Objective: There are five situations in a women’s life during which hormone fluctuations make them more susceptible to oral health problems – during puberty, at certain points in the monthly menstrual cycle, when using birth control pills, dur
Externí odkaz: https://doaj.org/article/81b832922b754ff0bc95bb82faf10562
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3
ACROBAT Edge: Safety and efficacy of switching injected SRLs to oral paltusotine in patients with acromegaly
Autor: Monica R Gadelha, Murray B Gordon, Mirjana Doknic, Emese Mezősi, Miklós Tóth, Harpal Randeva, Tonya Marmon, Theresa Jochelson, Rosa Luo, Michael Monahan, Ajay Madan, Christine Ferrara-Cook, R Scott Struthers, Alan Krasner
Publikováno v: The Journal of clinical endocrinology and metabolism.
Context Paltusotine is a once-daily, oral, nonpeptide small-molecule somatostatin receptor type 2 (SST2) agonist in clinical development for treatment of acromegaly. Objective This work aimed to evaluate change in insulin-like growth factor I (IGF-I)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9d7b46a2bde5060b0a9b5ef4c5a48b
https://pubmed.ncbi.nlm.nih.gov/36582134
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4
PSUN304 CRN04777 an Oral, Nonpeptide SST5-selective Somatostatin Agonist Dose Dependently Suppresses Basal and Stimulated Insulin Secretion
Autor: Christine Ferrara-Cook, Rosa Luo, Eduardo De La Torre, Yang Wang, Stephen Betz, Ajay Madan, Scott Struthers, Ulrike Hövelmann, Tim Heise, Alan Krasner
Publikováno v: Journal of the Endocrine Society. 6:A408-A409
Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in neonates, infants, and children, and is caused by genetic mutations in the insulin secretion pathway in pancreatic beta-cells. Current medical and surgical treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4adb17055f1a66b7dd175fc55840b5a4
https://doi.org/10.1210/jendso/bvac150.850
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5
Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers
Autor: Ajay Madan, Stacy Markison, Stephen F. Betz, Alan Krasner, Rosa Luo, Theresa Jochelson, Jason Lickliter, R. Scott Struthers
Publikováno v: Pituitary. 25(2)
Purpose Evaluate the pharmacodynamics, pharmacokinetics, and safety of paltusotine, an orally bioavailable, nonpeptide, somatostatin receptor subtype 2 (SST2) agonist being developed for the treatment of acromegaly and neuroendocrine tumors. Methods
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20574ba53c22e9b6dc20890c869cb90
https://pubmed.ncbi.nlm.nih.gov/35000098
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7
OR12-2 Inhibition of Basal and ACTH-stimulated Cortisol Secretion in Humans Using an Oral Nonpeptide ACTH Antagonist (CRN04894)
Autor: Stephen Betz, Christine Ferrara-Cook, Martha Hernandez-Illas, Rosa Luo, Ajay Madan, Stephanie Miller, Scott Struthers, Peter Trainer, Yang Wang, Alan Krasner
Publikováno v: Journal of the Endocrine Society. 6:A83-A83
CRN04894 is a potent orally bioavailable MC2R (adrenal cortex specific ACTH receptor) antagonist (Kb=0.34 nM) that is >1000-fold selective for MC2R over other melanocortin receptor subtypes. In rats receiving continuous administration of ACTH via sub
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31eae219dd4a68cbc115f07b370d6e6a
https://doi.org/10.1210/jendso/bvac150.172
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