Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Ajay K Nooka"'
Autor:
Amrita Krishnan, Ajay K Nooka, Ajai Chari, Alfred L Garfall, Thomas G Martin, Sandhya Nair, Xiwu Lin, Keqin Qi, Anil Londhe, Lixia Pei, Eric Ammann, Rachel Kobos, Jennifer Smit, Trilok Parekh, Alexander Marshall, Mary Slavcev, Saad Z Usmani
Publikováno v:
Journal of Comparative Effectiveness Research, Vol 12, Iss 6 (2023)
Aim: We compared the effectiveness of teclistamab versus real-world physician’s choice of therapy (RWPC) in triple-class exposed relapsed/refractory multiple myeloma. Materials & methods: MajesTEC- 1 eligibility criteria were applied to the RWPC
Externí odkaz:
https://doaj.org/article/d2234f01c82748d787b0b8d1a00b2e7e
Autor:
Yi Lin, Madhav Dhodapkar, Aaron P Rapoport, Ajai Chari, Nina Shah, Jack Aiello, David E Avigan, Jesus G Berdeja, Ivan M Borrello, Adam D Cohen, Karthik Ganapathi, Lissa Gray, Damian Green, Amrita Krishnan, Elisabet Manasanch, Nikhil C Munshi, Ajay K Nooka, Eric L Smith, Ravi Vij
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Outcomes in multiple myeloma (MM) have improved dramatically in the last two decades with the advent of novel therapies including immunomodulatory agents (IMiDs), proteasome inhibitors and monoclonal antibodies. In recent years, immunotherapy for the
Externí odkaz:
https://doaj.org/article/cfade875c1d0413986d344c84a15d63a
Autor:
Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with I
Externí odkaz:
https://doaj.org/article/ab542c51a366402d8b83cd98c687f243
Autor:
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin
Externí odkaz:
https://doaj.org/article/f7edb1aa7e034097bfaeab285876053f
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
Paula Rodriguez-Otero, Sikander Ailawadhi, Bertrand Arnulf, Krina Patel, Michele Cavo, Ajay K. Nooka, Salomon Manier, Natalie Callander, Luciano J. Costa, Ravi Vij, Nizar J. Bahlis, Philippe Moreau, Scott R. Solomon, Michel Delforge, Jesus Berdeja, Anna Truppel-Hartmann, Zhihong Yang, Linda Favre-Kontula, Fan Wu, Julia Piasecki, Mark Cook, Sergio Giralt
Publikováno v:
New England Journal of Medicine. 388:1002-1014
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3440321f2004e72b55d4ac3815f0b20e
https://doi.org/10.1056/nejmoa2213614
https://doi.org/10.1056/nejmoa2213614
Autor:
Andres Chang, Akil Akhtar, Susanne L. Linderman, Lilin Lai, Victor M. Orellana-Noia, Rajesh Valanparambil, Hasan Ahmed, Veronika I. Zarnitsyna, Ashley A. McCook-Veal, Jeffrey M. Switchenko, Jean L. Koff, Kristie A. Blum, Amy A. Ayers, Colin B. O'Leary, Michael C. Churnetski, Shahana Sulaiman, Melissa Kives, Preston Sheng, Carl W. Davis, Ajay K. Nooka, Rustom Antia, Madhav V. Dhodapkar, Mehul S. Suthar, Jonathon B. Cohen, Rafi Ahmed
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(26)
PURPOSE Patients with non-Hodgkin lymphoma including chronic lymphocytic leukemia (NHL/CLL) are at higher risk of severe SARS-CoV-2 infection. We investigated vaccine-induced antibody responses in patients with NHL/CLL against the original SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223b4a39ae3f005ec23f2d272130f6c9
https://pubmed.ncbi.nlm.nih.gov/35436146
https://pubmed.ncbi.nlm.nih.gov/35436146
Autor:
Andres Chang, Akil Akhtar, Lilin Lai, Victor M. Orellana-Noia, Susanne L. Linderman, Ashley A. McCook-Veal, Jeffrey M. Switchenko, Manpreet Saini, Rajesh M. Valanparambil, Kristie A. Blum, Pamela B. Allen, Mary Jo Lechowicz, Jason T. Romancik, Amy Ayers, Alyssa Leal, Colin B. O'Leary, Michael C. Churnetski, Katelin Baird, Melissa Kives, Jens Wrammert, Ajay K. Nooka, Jean L. Koff, Madhav V. Dhodapkar, Mehul S. Suthar, Jonathon B. Cohen, Rafi Ahmed
Publikováno v:
Cancer Research Communications. 2:1684-1692
Patients with non–Hodgkin lymphoma and chronic lymphocytic leukemia (NHL/CLL) elicit inadequate antibody responses after initial SARS-CoV-2 vaccination and remain at high risk of severe COVID-19 disease. We investigated IgG, IgA, and IgM responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dba9bfe1a34844f16a5b22d8df72770
https://doi.org/10.1158/2767-9764.crc-22-0471
https://doi.org/10.1158/2767-9764.crc-22-0471
Autor:
Maryam I. Azeem, Ajay K. Nooka, Uma Shanmugasundaram, Narayanaiah Cheedarla, Sayalee Potdar, Renee Julia Manalo, Alberto Moreno, Jeffrey M. Switchenko, Suneethamma Cheedarla, Deon Bryant Doxie, Roman Radzievski, Madison Leigh Ellis, Kelly E. Manning, Bushra Wali, Rajesh M. Valanparambil, Kathryn T. Maples, Essence Baymon, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, John D. Roback, Alessandro Sette, Rafi Ahmed, Mehul S. Suthar, Andrew S. Neish, Madhav V. Dhodapkar, Kavita M. Dhodapkar
Publikováno v:
Blood Cancer Discovery. 4:106-117
Patients with multiple myeloma (MM) mount suboptimal neutralizing antibodies (nAb) following 2 doses of SARS-CoV-2 mRNA vaccines. Currently, circulating SARS-CoV-2 variants of concern (VOC) carry the risk of breakthrough infections. We evaluated immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c80245436565a67f2a8a7f212f7b3bc
https://doi.org/10.1158/2643-3230.bcd-22-0173
https://doi.org/10.1158/2643-3230.bcd-22-0173
Autor:
Ajay K Nooka, Jonathan L Kaufman, Cesar Rodriguez, Andrzej Jakubowiak, Yvonne Efebera, Brandi Reeves, Tanya Wildes, Sarah A Holstein, Larry D Anderson, Ashraf Badros, Leyla Shune, Ajai Chari, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S Lin, Paul G Richardson, Peter Voorhees
Publikováno v:
Future Oncology. 18:4443-4456
What is this summary about? This is a summary of a publication about Black participants of the GRIFFIN clinical study that was published in Blood Cancer Journal in April 2022. The GRIFFIN clinical study looked at the treatment combination of daratumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47dbc0c121be4ca8e423206d901fca66
https://doi.org/10.2217/fon-2022-0775
https://doi.org/10.2217/fon-2022-0775