Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ajay J. Narasimha"'
Autor:
John A Corbin, Vinay Bhaskar, Ira D Goldfine, Daniel H Bedinger, Angela Lau, Kristen Michelson, Lisa M Gross, Betty A Maddux, Hua F Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R Watson, Ajay J Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Steve R Lee, Steve Wong, Diane Wilcock, Mark L White
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88684 (2014)
Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human
Externí odkaz:
https://doaj.org/article/ec07dde7e6df4a3f9009b736ea547f18
Autor:
Shirley Zhu, David Chemla-Vogel, Ajay J. Narasimha, Lynn Webster, Angela Lau, Sujeewa D. Wijesuriya, Diane Wilcock, Raphael Levy, Hassan Issafras, Paul Rubin, Hua F. Kuan, Catarina Tran, Daniel Bedinger, Vinay Bhaskar, Ira D. Goldfine, John Corbin, Xiaorong Wu, Susan R. Watson, Llewelyn Lao, Naichi Liu, Kristen Michelson, Masahisa Handa, Lisa Gross, Steve R. Lee, Steve Wong, Betty A. Maddux, Mark L. White
Publikováno v:
mAbs
Novel therapies are needed for the treatment of hypoglycemia resulting from both endogenous and exogenous hyperinsulinema. To provide a potential new treatment option, we identified XMetD, an allosteric monoclonal antibody to the insulin receptor (IN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981aef464820bb0d1ce04c389f12b84
https://doi.org/10.4161/mabs.26871
https://doi.org/10.4161/mabs.26871
Autor:
Masahisa Handa, Diane Wilcock, Ajay J. Narasimha, Raphael Levy, Lynn Webster, Sujeewa D. Wijesuriya, John Corbin, Steve R. Lee, Hua F. Kuan, Daniel Bedinger, Xiaorong Wu, Vinay Bhaskar, Shirley Zhu, David Chemla-Vogel, Lisa Gross, Steve Wong, Mark L. White, Susan R. Watson, Naichi Liu, Catarina Tran, Ira D. Goldfine, Angela Lau, Betty A. Maddux
Publikováno v:
Diabetes
Many patients with diabetes mellitus (both type 1 and type 2) require therapy to maintain normal fasting glucose levels. To develop a novel treatment for these individuals, we used phage display technology to target the insulin receptor (INSR) comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de204c14d0a31a17006c9725a778704b
http://europepmc.org/articles/PMC3331746
http://europepmc.org/articles/PMC3331746
Autor:
Srinivasa T. Reddy, Tomo-o Ishikawa, Junji Watanabe, Ajay J. Narasimha, Martin G. Martin, James A. Lin, Ani Shahbazian, Harvey R. Herschman
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Cyclooxygenase-2 (COX-2) is an important regulator of inflammation implicated in the development of a variety of diseases, including inflammatory bowel disease (IBD). However, the regulation of intestinal inflammation by COX-2 is poorly understood. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b136d7e41de4d5589852bda8ddb4c75
https://doi.org/10.1152/ajpgi.00468.2009
https://doi.org/10.1152/ajpgi.00468.2009
Autor:
Ajay J. Narasimha, Srinivasa T. Reddy, Harvey R. Herschman, Tomo-o Ishikawa, Junji Watanabe, Lily Wu, Saul J. Priceman
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:260-268
Objective— The role of myeloid cell cyclooxygenase-2 (COX-2) in the progression of atherosclerosis has not been clearly defined. Methods and Results— We investigated the role of COX-2 expressed in the myeloid lineage in the development of atheros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df843acd83734110e6edcfa68eae383e
https://doi.org/10.1161/atvbaha.109.198762
https://doi.org/10.1161/atvbaha.109.198762
Autor:
Gattadahalli M. Anantharamaiah, Andrew D. Watson, Mohamad Navab, Joy S. Frank, Babak Yekta, Georgette M. Buga, Alan M. Fogelman, Ashkan Hakhamian, Ajay J. Narasimha, Srinivasa T. Reddy, Giuliano A. Mottino
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 192-205 (2008)
LDL receptor-null (LDLR(-/-)) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F. Focusing on the kidney, LDLR(-/-)mice were fed a WD with D-4F o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4810899c703e8f4d69da4dab1d2b11
https://doi.org/10.1194/jlr.m700433-jlr200
https://doi.org/10.1194/jlr.m700433-jlr200
Autor:
Nora Rozengurt, Martin G. Martin, Srinivasa T. Reddy, Robert Langenbach, Jonathan Braun, Jenny S. Wang, Ajay J. Narasimha, James A. Lin, Junji Watanabe
Publikováno v:
Prostaglandinsother lipid mediators. 84(3-4)
Cyclooxygenases (COX) regulate a variety of inflammatory diseases, including inflammatory bowel disease (IBD). While the pathological effects of COX-1 inhibition by NSAIDs on intestinal ulceration are well established, the role of COX-2 on intestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eb56e0dff247fadf9eb2c8c9233c89
https://pubmed.ncbi.nlm.nih.gov/17991612
https://pubmed.ncbi.nlm.nih.gov/17991612
Autor:
Sujeewa D. Wijesuriya, Ajay J. Narasimha, Xiaorong Wu, Lynn Webster, Lisa Gross, Catarina Tran, Daniel Bedinger, Hua F. Kuan, Steve Wong, Susan R. Watson, Kristen Michelson, Betty A. Maddux, John Corbin, Masahisa Handa, Shirley Zhu, Angela Lau, Llewelyn Lao, Naichi Liu, Ira D. Goldfine, Mark L. White, Steve R. Lee, Diane Wilcock, Vinay Bhaskar, Raphaël Lévy, David Chemla-Vogel
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88684 (2014)
PLoS ONE
PLoS ONE
Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64576dbe1d46057140b004ce590d1e4b
https://doi.org/10.1371/journal.pone.0088684
https://doi.org/10.1371/journal.pone.0088684