Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Ajay Gopinathan"'
Publikováno v:
Biophysical Reports, Vol 4, Iss 3, Pp 100171- (2024)
A common type of cytoskeletal morphology involves multiple microtubules converging with their minus ends at the microtubule organizing center (MTOC). The cargo-motor complex will experience ballistic transport when bound to microtubules or diffusive
Externí odkaz:
https://doaj.org/article/fc0aa3bd620f45ff8107d9f34af8a256
Autor:
Ryan Brisbin, Mark Bartolo, Michael Leville, Arya K. Rajan, Basharat Jahan, Kara E. McCloskey, Ajay Gopinathan, Sayantani Ghosh, Ryan Baxter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract We investigate the effect of bis(imino)pyridine (BIP) ligands in guiding self-assembly of semiconducting CdSe/ZnS quantum dots (QDs) into three-dimensional multi-layered shells with diameters spanning the entire mesoscopic range, from 200 nm
Externí odkaz:
https://doaj.org/article/5a84d3b1a4f44c1491905b5a1b812aad
Autor:
Niranjan Sarpangala, Ajay Gopinathan
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010217 (2022)
In cells, multiple molecular motors work together as teams to carry cargoes such as vesicles and organelles over long distances to their destinations by stepping along a network of cytoskeletal filaments. How motors that typically mechanically interf
Externí odkaz:
https://doaj.org/article/dd4a885c35994f38ac09b09dd363390d
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Many types of animal cells exert active, contractile forces and mechanically deform their elastic substrate, to accomplish biological functions such as migration. These substrate deformations provide a mechanism in principle by which cells may sense
Externí odkaz:
https://doaj.org/article/78a46ea84c1c43a7b2910a060f326a8c
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The actin homolog MreB directs cell-wall insertion and maintains cell shape in many rod-shaped bacteria. Here, Shi et al. perform molecular dynamics simulations for MreB to extract mechanical parameters for inputs into a coarse-grained biophysical po
Externí odkaz:
https://doaj.org/article/efd723093a744b6da7132d60fc3c5c6d
Autor:
David Ando, Ajay Gopinathan
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169455 (2017)
Nucleocytoplasmic transport is highly selective, efficient, and is regulated by a poorly understood mechanism involving hundreds of disordered FG nucleoporin proteins (FG nups) lining the inside wall of the nuclear pore complex (NPC). Previous resear
Externí odkaz:
https://doaj.org/article/bd11995e213d4666be835114e1b3679d
Autor:
Drew E Glaser, William S Turner, Nicole Madfis, Lian Wong, Jose Zamora, Nicholas White, Samuel Reyes, Andrew B Burns, Ajay Gopinathan, Kara E McCloskey
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166663 (2016)
Embryonic stem cells (ESC) and induced pluripotent stem (iPS) cells are attractive in vitro models of vascular development, therapeutic angiogenesis, and tissue engineering. However, distinct ESC and iPS cell lines respond differentially to the same
Externí odkaz:
https://doaj.org/article/b6cfe770140f44b894fe208bef39ff73
Autor:
Konstantinos Tsekouras, Igor Goncharenko, Michael E Colvin, Kerwyn Casey Huang, Ajay Gopinathan
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65623 (2013)
Although targeting of cancer cells using drug-delivering nanocarriers holds promise for improving therapeutic agent specificity, the strategy of maximizing ligand affinity for receptors overexpressed on cancer cells is suboptimal. To determine design
Externí odkaz:
https://doaj.org/article/25e7da70d9bb4413baed8e3c9d3dad8d
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73831 (2013)
Bioinformatics of disordered proteins is especially challenging given high mutation rates for homologous proteins and that functionality may not be strongly related to sequence. Here we have performed a novel bioinformatic analysis, based on the spat
Externí odkaz:
https://doaj.org/article/64c61bb5628d4f628fa604a759801dc7
Publikováno v:
Journal of Theoretical Biology. 570:111537
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5086dae5424378884efd2cdf44fbe5
https://doi.org/10.1016/j.jtbi.2023.111537
https://doi.org/10.1016/j.jtbi.2023.111537