Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Ajay A. Vashisht"'
Autor:
Jorge Hernández-García, Borja Diego-Martin, Peggy Hsuanyu Kuo, Yasaman Jami-Alahmadi, Ajay A. Vashisht, James Wohlschlegel, Steven E. Jacobsen, Miguel A. Blázquez, Javier Gallego-Bartolomé
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The ancestral history of SWI/SNF subunits, responsible for nucleosome positioning, are explored in this work, revealing a plant SWI/SNF complex similar to the animal BAF subclass.
Externí odkaz:
https://doaj.org/article/67661939e7134b0f832753801a3f1631
Autor:
Shilpa Hebbar, Ganesh Panzade, Ajay A. Vashisht, James A. Wohlschlegel, Isana Veksler-Lublinsky, Anna Y. Zinovyeva
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract microRNAs (miRNAs) are crucial for normal development and physiology. To identify factors that might coordinate with miRNAs to regulate gene expression, we used 2′O-methylated oligonucleotides to precipitate Caenorhabditis elegans let-7, m
Externí odkaz:
https://doaj.org/article/0d21b2655acd4ddb94d7327df8708ac2
Autor:
Peter S. Back, Andy S. Moon, Rebecca R. Pasquarelli, Hannah N. Bell, Juan A. Torres, Allan L. Chen, Jihui Sha, Ajay A. Vashisht, James A. Wohlschlegel, Peter J. Bradley
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The Toxoplasma inner membrane complex (IMC) is a unique organelle that plays critical roles in parasite motility, invasion, egress, and replication. The IMC is delineated into the apical, body, and basal regions, defined by proteins that loc
Externí odkaz:
https://doaj.org/article/85821a7e05bd4ee997f0826bc219e1e4
Autor:
Huan Wang, Tracey W. Chan, Ajay A. Vashisht, Brian G. Drew, Anna C. Calkin, Thurl E. Harris, James A. Wohlschlegel, Xinshu Xiao, Karen Reue
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Lipin 1 regulates cellular lipid homeostasis through roles in glycerolipid synthesis (through phosphatidic acid phosphatase activity) and transcriptional coactivation. Lipin 1–deficient individuals exhibit episodic disease symptoms that are trigger
Externí odkaz:
https://doaj.org/article/1ff759e379464c57a35ea1198f97e92c
Autor:
Somsakul Pop Wongpalee, Shiheng Liu, Javier Gallego-Bartolomé, Alexander Leitner, Ruedi Aebersold, Wanlu Liu, Linda Yen, Maria A. Nohales, Peggy Hsuanyu Kuo, Ajay A. Vashisht, James A. Wohlschlegel, Suhua Feng, Steve A. Kay, Z. Hong Zhou, Steven E. Jacobsen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
RNA polymerase V transcription in plants, which is needed DNA methylation and transcriptional silencing, requires components of the DDR complex. Here the authors show that all components of the DDR complex co-localize with Pol V and report the cryoEM
Externí odkaz:
https://doaj.org/article/5c382745983c4f368ca62e85724d1bdc
Autor:
Jessica P. Lao, Katie M. Ulrich, Jeffrey R. Johnson, Billy W. Newton, Ajay A. Vashisht, James A. Wohlschlegel, Nevan J. Krogan, David P. Toczyski
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3931-3944 (2018)
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling casca
Externí odkaz:
https://doaj.org/article/de2f24e8cce94c43a4850912c342577e
Autor:
Qiao Zhang, Ajay A. Vashisht, Jason O’Rourke, Stéphane Y Corbel, Rita Moran, Angelica Romero, Loren Miraglia, Jia Zhang, Eric Durrant, Christian Schmedt, Srinath C. Sampath, Srihari C. Sampath
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Cellular fusion is essential for skeletal muscle development. Here the authors identify Minion as a microprotein required for myoblast fusion and skeletal muscle formation, and show that co-expression of Minion and Myomaker is sufficient to induce cy
Externí odkaz:
https://doaj.org/article/5037962f1d194b6898a8441181d864fd
Autor:
Caroline M. Mota, Allan L. Chen, Kevin Wang, Santhosh Nadipuram, Ajay A. Vashisht, James A. Wohlschlegel, Tiago W. P. Mineo, Peter J. Bradley
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The development of molecular genetics has greatly enhanced the study of the biology and pathology associated with parasites of the phylum Apicomplexa. We have established a system specifically designed for Neospora caninum, and used this sys
Externí odkaz:
https://doaj.org/article/67bd85191a8e480088804d6e05943eac
Autor:
Caroline M. Mota, Ana C. M. Oliveira, Marcela Davoli-Ferreira, Murilo V. Silva, Fernanda M. Santiago, Santhosh M. Nadipuram, Ajay A. Vashisht, James A. Wohlschlegel, Peter J. Bradley, João S. Silva, José R. Mineo, Tiago W. P. Mineo
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/53f84ec4ba004632b459a4aca5de045a
Autor:
Justyna Nitarska, Jacob G. Smith, William T. Sherlock, Michele M.G. Hillege, Alexi Nott, William D. Barshop, Ajay A. Vashisht, James A. Wohlschlegel, Richard Mitter, Antonella Riccio
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1683-1698 (2016)
Histone modifications and chromatin remodeling represent universal mechanisms by which cells adapt their transcriptional response to rapidly changing environmental conditions. Extensive chromatin remodeling takes place during neuronal development, al
Externí odkaz:
https://doaj.org/article/7a1260dfcfd94e82b4e359768a60c051