Splice variants as novel targets in pancreatic ductal adenocarcinoma

Autor: Jun Wang, Laurent Dumartin, Andrea Mafficini, Pinar Ulug, Ajanthah Sangaralingam, Namaa Audi Alamiry, Tomasz P. Radon, Roberto Salvia, Rita T. Lawlor, Nicholas R. Lemoine, Aldo Scarpa, Claude Chelala, Tatjana Crnogorac-Jurcevic

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Despite a wealth of genomic information, a comprehensive alternative splicing (AS) analysis of pancreatic ductal adenocarcinoma (PDAC) has not been performed yet. In the present study, we assessed whole exome-based transcriptome and AS profi

Externí odkaz: https://doaj.org/article/5e296d11dc7c438894ef3382cb3a4a71

Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome

Autor: Belinda Gray, Alban-Elouen Baruteau, Albert A. Antolin, Alan Pittman, Giselle Sarganas, Mariam Molokhia, Marieke T. Blom, Rachel Bastiaenen, Abdenasser Bardai, Silvia G. Priori, Carlo Napolitano, Peter E. Weeke, Saad A. Shakir, Wilhelm Haverkamp, Jordi Mestres, Bo Winkel, Adam A. Witney, Irina Chis-Ster, Ajanthah Sangaralingam, A. John Camm, Jacob Tfelt-Hansen, Dan M. Roden, Hanno L. Tan, Edeltraut Garbe, Miriam Sturkenboom, Elijah R. Behr

Publikováno v: Circulation. Genomic and precision medicine, 15(1). Lippincott Williams and Wilkins Ltd.
Gray, B, Baruteau, A-E, Antolin, A A, Pittman, A, Sarganas, G, Molokhia, M, Blom, M T, Bastiaenen, R, Bardai, A, Priori, S G, Napolitano, C, Weeke, P E, Shakir, S A, Haverkamp, W, Mestres, J, Winkel, B, Witney, A A, Chis-Ster, I, Sangaralingam, A, Camm, A J, Tfelt-Hansen, J, Roden, D M, Tan, H L, Garbe, E, Sturkenboom, M & Behr, E R 2022, ' Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome ', Circulation. Genomic and precision medicine, vol. 15, no. 1, e003391, pp. 55-67 . https://doi.org/10.1161/CIRCGEN.121.003391
Gray, B, Baruteau, A E, Antolin, A A, Pittman, A, Sarganas, G, Molokhia, M, Blom, M T, Bastiaenen, R, Bardai, A, Priori, S G, Napolitano, C, Weeke, P E, Shakir, S A, Haverkamp, W, Mestres, J, Winkel, B, Witney, A A, Chis-Ster, I, Sangaralingam, A, Camm, A J, Tfelt-Hansen, J, Roden, D M, Tan, H L, Garbe, E, Sturkenboom, M & Behr, E R 2022, ' Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome ', Circulation. Genomic and precision medicine, vol. 15, no. 1, pp. E003391 . https://doi.org/10.1161/CIRCGEN.121.003391
Circulation: Genomic and Precision Medicine, 15(1). Lippincott Williams and Wilkins Ltd.

Background: Acquired long QT syndrome (aLQTS) is a serious unpredictable adverse drug reaction. Pharmacogenomic markers may predict risk. Methods: Among 153 aLQTS patients (mean age 58 years [range, 14–88], 98.7% White, 85.6% symptomatic), computat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c45cc42e50668beb2e68d0107a99c3
https://pure.amc.nl/en/publications/rare-variation-in-drug-metabolism-and-long-qt-genes-and-the-genetic-susceptibility-to-acquired-long-qt-syndrome(1ddd1b84-d0ed-4f6b-a8c3-5f6191ae7761).html

Gene expression profiling of breast cancer in Lebanese women

Autor: Nadine J. Makhoul, Emanuela Gadaleta, Ehab Saad Aldin, Joelle Makoukji, Sally El-Sitt, Ajanthah Sangaralingam, Claude Chelala, Mark Jabbour, Arafat Tfayli, Fouad Boulos, Rose-Mary Boustany, Maya Khalil

Publikováno v: Scientific Reports

Breast cancer is commonest cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. Molecular alterations in breast cancer are complex and involve cross-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363f469ce7e28c940046b69eac130013

A Phylogenetic Mixture Model for Gene Family Loss in Parasitic Bacteria

Autor: Ajanthah Sangaralingam, Matthew Spencer

Publikováno v: Molecular Biology and Evolution. 26:1901-1908

Gene families are frequently gained and lost from prokaryotic genomes. It is widely believed that the rate of loss was accelerated for some but not all gene families in lineages that became parasites or endosymbionts. This leads to a form of heterota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d2c7f569801204fc9b9c88e34ed507
https://doi.org/10.1093/molbev/msp102

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution

Autor: Ajanthah Sangaralingam, Jacek Marzec, Sameena Iqbal, David Wrench, Jude Fitzgibbon, Bryan D. Young, Guglielmo Rosignoli, Lena Hazanov, Tracy Chaplin, Simon Hallam, Emanuela Carlotti, John G. Gribben, Peter J. Campbell, Miri Michaeli, Ramit Mehr, Maria Calaminici

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0134833 (2015)

Understanding the dynamics of evolution of Follicular Lymphoma (FL) clones during disease progression is important for monitoring and targeting this tumor effectively. Genetic profiling of serial FL biopsies and examples of FL transmission following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae12d34e750ea7e8969bdce1fbf6e7d2
https://pubmed.ncbi.nlm.nih.gov/26325507