Výsledky vyhledávání - "Ajamete Kaykas"

Akademický článek

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

Autor: Victor J. T. Lin, Jiangnan Hu, Ashwini Zolekar, Max R. Salick, Parul Mittal, Jordan T. Bird, Peter Hoffmann, Ajamete Kaykas, Stephanie D. Byrum, Yu-Chieh Wang

Publikováno v: Cell Death and Disease, Vol 13, Iss 3, Pp 1-13 (2022)

Abstract Mutations in N-glycanase 1 (NGLY1), which deglycosylates misfolded glycoproteins for degradation, can cause NGLY1 deficiency in patients and their abnormal fetal development in multiple organs, including microcephaly and other neurological d

Externí odkaz: https://doaj.org/article/553c4ab68f75451a8014e32059a0cc7f

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Akademický článek

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

Autor: Rebekka Wegmann, Marilisa Neri, Sven Schuierer, Bilada Bilican, Huyen Hartkopf, Florian Nigsch, Felipa Mapa, Annick Waldt, Rachel Cuttat, Max R. Salick, Joe Raymond, Ajamete Kaykas, Guglielmo Roma, Caroline Gubser Keller

Publikováno v: Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)

Abstract We develop CellSIUS (Cell Subtype Identification from Upregulated gene Sets) to fill a methodology gap for rare cell population identification for scRNA-seq data. CellSIUS outperforms existing algorithms for specificity and selectivity for r

Externí odkaz: https://doaj.org/article/39c1e83d8d7d43228770031c5358d8f1

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Akademický článek

DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery

Autor: Chaoyang Ye, Daniel J. Ho, Marilisa Neri, Chian Yang, Tripti Kulkarni, Ranjit Randhawa, Martin Henault, Nadezda Mostacci, Pierre Farmer, Steffen Renner, Robert Ihry, Leandra Mansur, Caroline Gubser Keller, Gregory McAllister, Marc Hild, Jeremy Jenkins, Ajamete Kaykas

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

RNA-seq is a powerful tool to investigate how drugs affect the transcriptome but library construction can be costly. Here the authors introduce DRUG-seq, an automated platform for high-throughput transcriptome profiling.

Externí odkaz: https://doaj.org/article/7b7edf1cccfe4d95aaa258f27cffc83f

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Akademický článek

Genome-Scale CRISPR Screens Identify Human Pluripotency-Specific Genes

Publikováno v: Cell Reports, Vol 27, Iss 2, Pp 616-630.e6 (2019)

Summary: Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited by techni

Externí odkaz: https://doaj.org/article/39ad2f3ea8e94904a721c8785edecb36

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Akademický článek

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

Publikováno v: Stem Cell Reports, Vol 5, Iss 6, Pp 933-945 (2015)

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism

Externí odkaz: https://doaj.org/article/2296612bb377433592323ebb3a16fbea

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Akademický článek

Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6.

Autor: Lorna S Kategaya, Binita Changkakoty, Travis Biechele, William H Conrad, Ajamete Kaykas, Ramanuj Dasgupta, Randall T Moon

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6129 (2009)

BACKGROUND:Insights into how the Frizzled/LRP6 receptor complex receives, transduces and terminates Wnt signals will enhance our understanding of the control of the Wnt/ss-catenin pathway. METHODOLOGY/PRINCIPAL FINDINGS:In pursuit of such insights, w

Externí odkaz: https://doaj.org/article/516fb6050a954720911147a1b7528ba0

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Preclinical target validation for non-addictive therapeutics development for pain

Publikováno v: Expert Opinion on Therapeutic Targets. 26:811-822

The Helping to End Addiction Long-termIn 2020, the National Institutes of Health (NIH) held the Target Validation for Non-Addictive Therapeutics Development for Pain workshop to gather insights from key opinion leaders in academia, industry, and vent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a580423b3a5c4e04c717c45c0b1e987
https://doi.org/10.1080/14728222.2022.2147063

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Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids

Autor: Victor J. T. Lin, Jiangnan Hu, Ashwini Zolekar, Max R. Salick, Parul Mittal, Jordan T. Bird, Peter Hoffmann, Ajamete Kaykas, Stephanie D. Byrum, Yu-Chieh Wang

Publikováno v: Cell deathdisease. 13(3)

Mutations in N-glycanase 1 (NGLY1), which deglycosylates misfolded glycoproteins for degradation, can cause NGLY1 deficiency in patients and their abnormal fetal development in multiple organs, including microcephaly and other neurological disorders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e4ce26469c0a75f5c17ca30bcddca0
https://pubmed.ncbi.nlm.nih.gov/35322011

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