Zobrazeno 1 - 10
of 315
pro vyhledávání: '"Ajaikumar B. Kunnumakkara"'
Autor:
Babu Santha Aswani, Mangala Hegde, Ravichandran Vishwa, Mohammed S. Alqahtani, Mohamed Abbas, Hassan Ali Almubarak, Gautam Sethi, Ajaikumar B. Kunnumakkara
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-39 (2024)
Abstract Nuclear receptors (NRs) function as crucial transcription factors in orchestrating essential functions within the realms of development, host defense, and homeostasis of body. NRs have garnered increased attention due to their potential as t
Externí odkaz:
https://doaj.org/article/fff136fccb7041f48f03d158c36f1e3d
Autor:
Maniyamma Aswathy, Dey Parama, Mangala Hegde, Sherin DR, Ravi S. Lankalapalli, Kokkuvayil Vasu Radhakrishnan, Ajaikumar B. Kunnumakkara
Publikováno v:
ACS Omega, Vol 9, Iss 23, Pp 24252-24267 (2024)
Externí odkaz:
https://doaj.org/article/62c4307b7f184f1581248d9acfa9afe7
Autor:
Anjana Sajeev, Bandari BharathwajChetty, Mukesh Kumar Manickasamy, Mohammed S. Alqahtani, Mohamed Abbas, Mehdi Shakibaei, Gautam Sethi, Zhaowu Ma, Ajaikumar B. Kunnumakkara
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in women worldwide. Despite advancements in detection and therapy, the prognosis of OVC remains poor due to late diagnosis and the lack of effective therapeutic options at
Externí odkaz:
https://doaj.org/article/8e77faa1ada94f2cbf9bb53249a735da
Autor:
Mukesh Kumar Manickasamy, Sujitha Jayaprakash, Sosmitha Girisa, Aviral Kumar, Hiu Yan Lam, Elena Okina, Huiyan Eng, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Alan Prem Kumar, Ajaikumar B. Kunnumakkara
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-51 (2024)
Abstract Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally, causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to GLOBOCAN 2020, CRC ranks third in incidence and second in mort
Externí odkaz:
https://doaj.org/article/7b1279842bb64a6b8d8c40d92451e306
Autor:
Aviral Kumar, Bandari BharathwajChetty, Mukesh Kumar Manickasamy, Jyothsna Unnikrishnan, Mohammed S. Alqahtani, Mohamed Abbas, Hassan Ali Almubarak, Gautam Sethi, Ajaikumar B. Kunnumakkara
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107167- (2024)
Cancer has become a burgeoning global healthcare concern marked by its exponential growth and significant economic ramifications. Though advancements in the treatment modalities have increased the overall survival and quality of life, there are no de
Externí odkaz:
https://doaj.org/article/ac4a71009b8d4d1fb45f32aaeb507c07
Publikováno v:
Integrative Medicine Research, Vol 12, Iss 3, Pp 100968- (2023)
Background: Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequala
Externí odkaz:
https://doaj.org/article/641724568b284040858c0896bf0405d4
Autor:
Aranka Brockmueller, Sosmitha Girisa, Mahzad Motallebi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Hypoxia-inducible factor-1α (HIF-1α) is one of the major tumor-associated transcription factors modulating numerous tumor properties such as tumor cell metabolism, survival, proliferation, angiogenesis, and metastasis. Calebin A (CA), a
Externí odkaz:
https://doaj.org/article/a1b7502684b24dc6a0b39f5e67685600
Autor:
Anjana Sajeev, Bandari BharathwajChetty, Ravichandran Vishwa, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara
Publikováno v:
Non-Coding RNA, Vol 9, Iss 5, p 63 (2023)
Head and neck cancers (HNC) encompass a broad spectrum of neoplastic disorders characterized by significant morbidity and mortality. While contemporary therapeutic interventions offer promise, challenges persist due to tumor recurrence and metastasis
Externí odkaz:
https://doaj.org/article/5a00fdd8851f4b27a9430c4668b8b293
Autor:
Aranka Brockmueller, Anna-Lena Mueller, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal, Mehdi Shakibaei
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chronic diseases including cancer have high case numbers as well as mortality rates. The efficient treatment of chronic diseases is a major ongoing medical challenge worldwide, because of their complexity and many inflammatory pathways such as JNK, p
Externí odkaz:
https://doaj.org/article/37c7a2395752485da8924353b3c230b6
Autor:
Sosmitha Girisa, Sahu Henamayee, Dey Parama, Varsha Rana, Uma Dutta, Ajaikumar B. Kunnumakkara
Publikováno v:
Molecular Biomedicine, Vol 2, Iss 1, Pp 1-23 (2021)
Abstract Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell. One of those alterations associated with cancer corresponds to differential expression of Farnesoid X receptor (FXR), a nuclear receptor regulating
Externí odkaz:
https://doaj.org/article/e89f09bfc87849cb8cf022bbab9e3bef