Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ajaib S Paintlia"'
Autor:
Carrie L Tatar, Sunita Appikatla, Denise A Bessert, Ajaib S Paintlia, Inderjit Singh, Robert P Skoff
Publikováno v:
ASN Neuro, Vol 2 (2010)
PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Trans
Externí odkaz:
https://doaj.org/article/bf7872d795bf4914aad48bc15cffe042
Publikováno v:
Glia. 61:1500-1517
We earlier documented that lovastatin (LOV)-mediated inhibition of small Rho GTPases activity protects vulnerable oligodendrocytes (OLs) in mixed glial cell cultures stimulated with Th1 cytokines and in a murine model of multiple sclerosis (MS). Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c204595fb90797e3a0a32a0b9c225b62
https://doi.org/10.1002/glia.22537
https://doi.org/10.1002/glia.22537
Publikováno v:
Journal of Neurochemistry. 116:508-521
Th1 cytokine-induced loss of oligodendrocytes (OLs) is associated with axonal loss in CNS demyelinating diseases such as multiple sclerosis (MS)that contributes to neurological disabilities in affected individuals. Recent studies indicated that, in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a949f4b3ec498be6565eac2c0f1b4fa
https://doi.org/10.1111/j.1471-4159.2010.07136.x
https://doi.org/10.1111/j.1471-4159.2010.07136.x
Publikováno v:
Glia. 57:182-193
Drug combination therapies for central nervous system (CNS) demyelinating diseases including multiple sclerosis (MS) are gaining momentum over monotherapy. Over the past decade, both in vitro and in vivo studies established that statins (HMG-CoA redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e554f8d031e929adc26fa0bc802275ee
https://doi.org/10.1002/glia.20745
https://doi.org/10.1002/glia.20745
Publikováno v:
Journal of Neurochemistry. 105:956-970
Glial cells secrete proinflammatory mediators in the brain in response to exogenous stimuli such as infection and injury. Previously, we documented that systemic maternal lipopolysaccharide (LPS)-exposure at embryonic gestation day 18 causes oligoden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6863206e455b468b76902f3d76966599
https://doi.org/10.1111/j.1471-4159.2007.05199.x
https://doi.org/10.1111/j.1471-4159.2007.05199.x
Publikováno v:
Experimental Neurology. 210:560-576
Cerebral white matter injury during prenatal maternal infection characterized as periventricular leukomalacia is the main substrate for cerebral palsy (CP) in premature infants. Previously, we reported that maternal LPS exposure causes oligodendrocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e61b30fb69d1965769c7be0b61d321
https://doi.org/10.1016/j.expneurol.2007.12.011
https://doi.org/10.1016/j.expneurol.2007.12.011
Publikováno v:
The American Journal of Pathology. 169:1012-1025
Combination therapy with multiple sclerosis (MS) therapeutics is gaining momentum over monotherapy for improving MS. Lovastatin, an HMG-CoA reductase inhibitor (statin), was immunomodulatory in an experimental autoimmune encephalomyelitis (EAE) model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b2de1fc0f66714e4054080597e65ef
https://doi.org/10.2353/ajpath.2006.051309
https://doi.org/10.2353/ajpath.2006.051309
Publikováno v:
The Journal of Immunology. 176:4385-4398
Th2 phenotype cytokine, IL-4, plays an important role in the regulation of Th1 cell responses and spontaneous remission of inflammatory CNS demyelinating diseases such as multiple sclerosis (MS). In this study we demonstrate IL-4-induced down-regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506abcab68178da9e5ba59916c560ccc
https://doi.org/10.4049/jimmunol.176.7.4385
https://doi.org/10.4049/jimmunol.176.7.4385
Autor:
Avtar K. Singh, Inderjit Singh, Miguel A. Contreras, Manjeet K. Paintlia, Romesh Stanislaus, Ehtishamul Haq, Mushfiquddin Khan, Ajaib S. Paintlia
Publikováno v:
Brain Research. 1022:1-11
Peroxisomes are ubiquitous subcellular organelles and abnormality in their biogenesis and specific gene defects leads to fatal demyelinating disorders. We report that neuroinflammatory disease in brain of experimental autoimmune encephalomyelitis (EA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6897b01d36e6c70c2de0ec39dfd8f1ce
https://doi.org/10.1016/j.brainres.2004.06.059
https://doi.org/10.1016/j.brainres.2004.06.059
Autor:
Avtar K. Singh, Manjeet K. Paintlia, Anne G. Gilg, Ernest Barbosa, Romesh Stanislaus, Ajaib S. Paintlia, Inderjit Singh
Publikováno v:
Journal of Neuroscience Research. 77:63-81
The attenuation of experimental autoimmune encephalomyelitis (EAE) by Lovastatin (LOV) has now been well established. The present study was designed to explore the global effect of LOV treatment on expression of immune-related genes in lumbar spinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b591a8ab901048dba20d6acc733d31f6
https://doi.org/10.1002/jnr.20130
https://doi.org/10.1002/jnr.20130