Single-cell nanobiopsy enables multigenerational longitudinal transcriptomics of cancer cells.

Autor: Marcuccio F; Faculty of Medicine, Imperial College London, London, UK.; Bragg Centre for Materials Research, University of Leeds, Leeds, UK.; School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK.; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Chau CC; Bragg Centre for Materials Research, University of Leeds, Leeds, UK.; School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK.; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Tanner G; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Elpidorou M; School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK.; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Finetti MA; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Ajaib S; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Taylor M; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Lascelles C; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Carr I; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Macaulay I; Earlham Institute, Norwich Research Park, Norwich, UK., Stead LF; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK., Actis P; Bragg Centre for Materials Research, University of Leeds, Leeds, UK.; School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK.

Publikováno v: Science advances [Sci Adv] 2024 Mar 08; Vol. 10 (10), pp. eadl0515. Date of Electronic Publication: 2024 Mar 06.

S-Nitrosoglutathione Induces Ciliary Neurotrophic Factor Expression in Astrocytes, Which Has Implications to Protect the Central Nervous System under Pathological Conditions

Autor: Paintlia, Manjeet K., Paintlia, Ajaib S., Singh, Avtar K., Singh, Inderjit

Publikováno v: In Journal of Biological Chemistry February 2013 288(6):3831-3843

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data.

Autor: Ajaib S; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Lodha D; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.; EMBL's European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Pollock S; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Hemmings G; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Finetti MA; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Gusnanto A; School of Mathematics, University of Leeds, Leeds, UK., Chakrabarty A; Department of Neuropathology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Ismail A; Department of Neuropathology, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Wilson E; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Varn FS; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Hunter B; Flow Cytometry Core Facility, Newcastle University, Newcastle, UK., Filby A; Flow Cytometry Core Facility, Newcastle University, Newcastle, UK., Brockman AA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Neurological Surgery, Vanderbilt Brain Institute, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., McDonald D; Flow Cytometry Core Facility, Newcastle University, Newcastle, UK., Verhaak RGW; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Ihrie RA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Stead LF; Leeds Institute of Medical Research, University of Leeds, Leeds, UK.

Publikováno v: Neuro-oncology [Neuro Oncol] 2023 Jul 06; Vol. 25 (7), pp. 1236-1248.

Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: Attenuation by N-acetyl cysteine

Autor: Paintlia, Manjeet K., Paintlia, Ajaib S., Contreras, Miguel A., Singh, Inderjit, Singh, Avtar K.

Publikováno v: In Experimental Neurology 2008 210(2):560-576

Increased Gene Expression Leads to Massive Microglial Cell Activation and Inflammation Throughout the Brain

Autor: Carrie L Tatar, Sunita Appikatla, Denise A Bessert, Ajaib S Paintlia, Inderjit Singh, Robert P Skoff

Publikováno v: ASN Neuro, Vol 2 (2010)

PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Trans

Externí odkaz: https://doaj.org/article/bf7872d795bf4914aad48bc15cffe042