Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ajai K. Chaudhary"'
Autor:
Basira G Abdul, Everett J. Perkins, Ajai K. Chaudhary, Enaksha R Wickremsinhe, Jennifer L Hanes, Kenneth J. Ruterbories, Naijia H Huang, John W Richard
Publikováno v:
Bioanalysis. 3:1635-1646
Background: The adoption of dried blood spot (DBS) sampling and analysis to support drug discovery and development requires the understanding of its bioanalytical feasibility as well as the distribution of the analyte in blood. Results: Demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd721a73c7f5cf44258039b444d6181
https://doi.org/10.4155/bio.11.124
https://doi.org/10.4155/bio.11.124
Autor:
Ajai K. Chaudhary, Ragu Ramanathan
Publikováno v:
Bioanalysis. 2:1181-1184
The inaugural Applied Pharmaceutical Analysis–India (APA–India) conference was held between 21 and 24 February 2010 in Hyderabad, India. The theme of the 2010 APA–India meeting was “The best of bioanalytical science in India: the role of bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::689d0d89952952c5f18e3cb3e4fb0b77
https://doi.org/10.4155/bio.10.78
https://doi.org/10.4155/bio.10.78
Autor:
Anthony J. DeStefano, Daniel Tang, Jacqueline A. O'Shaughnessy, Marian Kelley, Ajai K. Chaudhary, S. Peter King, Russell Weiner, Douglas M. Fast, C. T. Viswanathan
Publikováno v:
The AAPS Journal. 11:238-241
The Conference Report of the 3rd AAPS/FDA Bioanalytical Workshop (Crystal City III) endorsed the concept that assay methods supporting bioanalytical data in submissions must demonstrate assay reproducibility by using incurred samples. The present Wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8701cdb5f80696bcc8caa8e767717bdd
https://doi.org/10.1208/s12248-009-9100-9
https://doi.org/10.1208/s12248-009-9100-9
Publikováno v:
Annual Review of Analytical Chemistry. 1:357-396
Current drug discovery involves a highly iterative process pertaining to three core disciplines: biology, chemistry, and drug disposition. For most pharmaceutical companies the path to a drug candidate comprises similar stages: target identification,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4a28f29a42e4a865154a259abedfee
https://doi.org/10.1146/annurev.anchem.1.031207.112855
https://doi.org/10.1146/annurev.anchem.1.031207.112855
Autor:
Chris H. Takimoto, Alain C. Mita, Andrew Goetz, Robert D. Johnson, Lorinda Simms, Sharyn D. Baker, Tuhin K. Chaudhuri, Kathleen Molpus, Lisa A. Hammond, Christopher Sweeney, Eric K. Rowinsky, Anthony W. Tolcher, Alan Sandler, Miguel A. Villalona-Calero, Jane E. Latz, Amita Patnaik, Ajai K. Chaudhary
Publikováno v:
Journal of Clinical Oncology. 24:552-562
Purpose This phase I study was conducted to determine the toxicities, pharmacokinetics, and recommended doses of pemetrexed in cancer patients with normal and impaired renal function. Patients and Methods Patients received a 10-minute infusion of 150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3f19be364941fc737daa93fba6a08c7
https://doi.org/10.1200/jco.2004.00.9720
https://doi.org/10.1200/jco.2004.00.9720
Autor:
Phil Marder, Linda A. Battiato, Christopher Sweeney, Ajai K. Chaudhary, Karen Fife, Christopher Jordan, Alan B. Sandler, Isabelle Pouliquen, Michael S. Gordon, Lisa J. Green, Michael Burgess, Christopher A. Slapak, Dinesh P. de Alwis
Publikováno v:
Clinical Cancer Research. 10:3265-3272
Purpose: The purpose of this study was to investigate the safety and tolerability of Zosuquidar.3HCl, a potent inhibitor of P-glycoprotein (Pgp), when administered p.o. alone and in combination with doxorubicin and to determine whether Zosuquidar.3HC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055824e6ec53b95c2c30c298e7eb1c6f
https://doi.org/10.1158/1078-0432.ccr-03-0644
https://doi.org/10.1158/1078-0432.ccr-03-0644
Autor:
Ajai K. Chaudhary
Publikováno v:
Bioanalysis. 1:503-505
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba93587faf5d0bcf86c7386549964e34
https://doi.org/10.4155/bio.09.54
https://doi.org/10.4155/bio.09.54
Publikováno v:
Biomedical Chromatography. 13:455-461
A quantitative method was developed and validated for rapid and sensitive analysis of cimetidine in human plasma. The method involved the use of liquid chromatography (LC) coupled with atmospheric pressure chemical ionization (APCI) and selected reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8182213b3ad8a8fe8cefde60123feb00
https://doi.org/10.1002/(sici)1099-0801(199911)13:7<455::aid-bmc911>3.0.co
https://doi.org/10.1002/(sici)1099-0801(199911)13:7<455::aid-bmc911>3.0.co
Autor:
M Nokubo, G R Reddy, Ian A. Blair, Lawrence J. Marnett, Carol A. Rouzer, Ajai K. Chaudhary, D M Ferguson
Publikováno v:
Chemical Research in Toxicology. 10:181-188
A method is described for the assay of the major malondialdehyde-deoxyguanosine adduct (M1G) based on immunoaffinity purification and gas chromatography/electron capture/negative chemical ionization/mass spectrometry. A stable isotope of M1G-deoxyrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c984ecff2d745ef706c618f2dc7758aa
https://doi.org/10.1021/tx9601216
https://doi.org/10.1021/tx9601216
Autor:
Clark Tibbetts, Kaylon L. Bruner, Ajai K. Chaudhary, Mounir Benamira, Kristin A. Johnson, Lawrence J. Marnett
Publikováno v:
Carcinogenesis. 16:93-99
The mutagenicity of the lipid peroxidation product, malondialdehyde (MDA), was measured in the lacZ alpha forward mutation assay using a recombinant M13 phage, M13MB102. Single-stranded M13MB102 DNA was reacted with MDA at neutral pH and the modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6501e5e61faccfabc694272523543f02
https://doi.org/10.1093/carcin/16.1.93
https://doi.org/10.1093/carcin/16.1.93