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Akademický článek

Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts

Autor: Shaojie Liu, Donghui Han, Chao Xu, Fa Yang, Yu Li, Keying Zhang, Xiaolong Zhao, Jiayu Zhang, Tong Lu, Shiqi Lu, Changhong Shi, Rui Zhang, An-Gang Yang, Aizhi Zhao, Weijun Qin, Bo Yang, Weihong Wen

Publikováno v: Molecular Medicine, Vol 28, Iss 1, Pp 1-17 (2022)

Abstract Background Chronic liver injury induces pathological repair, resulting in fibrosis, during which hepatic stellate cells (HSCs) are activated and transform into myofibroblasts. CD248 is mainly expressed on myofibroblasts and was considered as

Externí odkaz: https://doaj.org/article/c851dadd0a02440085833c81f59977f3

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Akademický článek

Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody.

Autor: Denarda Dangaj, Karen L Abbott, Ananda Mookerjee, Aizhi Zhao, Pamela S Kirby, Raphael Sandaltzopoulos, Daniel J Powell, Antonin Lamazière, Don L Siegel, Claude Wolf, Nathalie Scholler

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28386 (2011)

Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and C

Externí odkaz: https://doaj.org/article/a34c0064476e43049f7bf1b7cab6706f

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Supplementary Figure 2 from A Novel Fully Human Antibody targeting Extracellular Domain of PSMA Inhibits Tumor Growth in Prostate Cancer

Autor: Weihong Wen, Weijun Qin, Aizhi Zhao, An-Gang Yang, Lingling Zhang, Pin Xie, Dian Jiao, Fa Yang, Guodong Li, Yueheng Han, Ming Wei, Guoxu Zheng, Qiang Zhang, Shengjia Shi, Donghui Han, Jieheng Wu

(S2A) Competitive binding assay to examine the binding specificity of PSMAb. Different amount of PSMA protein was incubated with PSMAb before it was applied for the incubation with PSMA positive C4-2 cells and examined by flow cytometry. (S2B) DSC as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bb2282a64a0281ea985637e0cd9379
https://doi.org/10.1158/1535-7163.22506372

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Data from A Novel Fully Human Antibody targeting Extracellular Domain of PSMA Inhibits Tumor Growth in Prostate Cancer

Prostate cancer is the most commonly diagnosed malignancy in men and the second leading cause of cancer-related death. It is of vital importance to develop new strategies for prostate cancer therapy. PSMA (prostate-specific membrane antigen) is speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d75e439b2adb999fe2607582f5062477
https://doi.org/10.1158/1535-7163.c.6538383.v1

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Therapeutic effects of human monoclonal PSMA antibody-mediated TRIM24 siRNA delivery in PSMA-positive castration-resistant prostate cancer

Autor: Shengjia Shi, Jiangwei Chen, Angang Yang, Yu Li, Fa Yang, Donghui Han, Kai-Liang Zhang, Jieheng Wu, Lijuan Wang, Jingliang Zhang, Dian Jiao, Wei-Hong Wen, Aizhi Zhao, Guoxu Zheng, Weijun Qin

Publikováno v: Theranostics

Background and Aims: Prostate specific membrane antigen (PSMA) is specifically expressed on prostate epithelial cells and markedly overexpressed in almost all prostate cancers. TRIM24 is also up-regulated from localized prostate cancer to metastatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b195854849a33335fbcf040df9a8f3
https://doi.org/10.7150/thno.29884

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