Výsledky vyhledávání - "Aizawa, Shirou"

Involvement of Illegitimate V(D)J Recombination or Microhomology-Mediated Nonhomologous End-Joining in the Formation of Intragenic Deletions of the Notch1 Gene in Mouse Thymic Lymphomas

Autor: Tsuji, Hideo, Ishii-Ohba, Hiroko, Katsube, Takanori, Ukai, Hideki, Aizawa, Shirou, Doi, Masahiro, Hioki, Kyoji, Ogiu, Toshiaki

Publikováno v: Cancer Research. 64:8882-8890

Deregulated V(D)J recombination-mediated chromosomal rearrangements are implicated in the etiology of B- and T-cell lymphomagenesis. We describe here three pathways for the formation of the 5' deletions of Notch1 gene in thymic lymphomas of wild-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::70acbc402bde2c1d461dd325594231cf
https://repo.qst.go.jp/records/44524

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Adaptive Response in Embryogenesis: V. Existence of Two Efficient Dose-Rate Ranges for 0.3Gy of Priming Irradiation to Adapt Mouse Fetures

Autor: Bing, Wang, Ohyama, Harumi, Shang, Yi, Tanaka, Kaoru, Aizawa, Shirou, Yukawa, Osami, Hayata, Isamu

Publikováno v: Radiation Research. 161:264-272

Radioadaptive response (AR) manifests an important phenomenon in radiobiology. Study of conditions essential for the induction of AR is of critical significance to understanding the novel biodefense mechanisms against the hazardous effects of irradia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::e6b43632ebf2072951891c2a5f45f9f9
https://repo.qst.go.jp/records/43368

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Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice

Autor: Bing, Wang, Ohyama, Harumi, Tanaka, Kaoru, Morimoto, Yasuko, Aizawa, Shirou, Yukawa, Osami, Hayata, Isamu

The limb developing system is a suitable model to study the teratogenetic effect of radiation in fetal mice. We found that radiation-induced apoptosis in the predigital regions of fetal limb buds was responsible for digital defects. In ICR and C57BL/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::244f2b7beade77f47c8dfadcc39a6c60
https://repo.qst.go.jp/records/60401

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Protective and Detrimental Bystander Effects Induced by X-Irradiation in the Limb Bud Cell Cultures of Fetal Mice

Autor: Bing, Wang, Ohyama, Harumi, Shang, Yi, Yukawa, Osami, Aizawa, Shirou, Hayata, Isamu

Radioadaptive response and bystander effect represent important phenomena in radiobiology with an impact on the novel bioresponse mechanisms and risk estimates. The micromass cultures of limb bud cells (LBCs) provide an in vitro cellular maturation s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::c90a3969fff9d945aa1a5977f8d9dd46
https://repo.qst.go.jp/records/67459

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Studies on a role of XRCC4 in human cells

Autor: Mori, Masahiko, Itsukaichi, Hiromi, Kanda, Reiko, Nakamura, Atsuko, Shiomi, Naoko, Aizawa, Shirou, Shiomi, Tadahiro

Ionizing radiation produces a variety of lesions in DNA including single-strand breaks, double strand breaks and base damage. The repair of DNA double-strand breaks in essential for the maintenance of genomic integrity. Failure to repair DNA double-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::b3f974a8a4f18c6d0c2948fb56f81ac6
https://repo.qst.go.jp/records/67424

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Early detection of p53-/- thymocytes appeared during radiation-induced thymic lymphomagenesis in p53 heterozygous (+/-) B10 mice

Autor: Aizawa, Shirou, Tanaka, Kaoru, Mori, Masahiko, Yoshida, Kazuko

Radiation exposure is know to be highly leukemmogenic, but the mechanism action is not yet understood. Studies with the p53 heterozygous mouse have shown that a single dose of radiation can induce a high incidence of thymic lymphomas, most of which m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::36079db43c9bb3ecead1e4b638ad3a5b
https://repo.qst.go.jp/records/59901

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