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Akademický článek

Using the structural diversity of RNA: protein interfaces to selectively target RNA with small molecules in cells: methods and perspectives

Autor: Aixiao Li, Ahmed Bouhss, Marie-Jeanne Clément, Cyril Bauvais, J. Paul Taylor, Guillaume Bollot, David Pastré

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

In recent years, RNA has gained traction both as a therapeutic molecule and as a therapeutic target in several human pathologies. In this review, we consider the approach of targeting RNA using small molecules for both research and therapeutic purpos

Externí odkaz: https://doaj.org/article/22c47e5584934302a02e842601707265

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Akademický článek

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Autor: Jeff Charles Kremer, Bethany Cheree Prudner, Sara Elaine Stubbs Lange, Gregory Richard Bean, Matthew Bailey Schultze, Caitlyn Brook Brashears, Megan DeAnna Radyk, Nathan Redlich, Shin-Cheng Tzeng, Kenjiro Kami, Laura Shelton, Aixiao Li, Zack Morgan, John Stephen Bomalaski, Takashi Tsukamoto, Jon McConathy, Loren Scott Michel, Jason Matthew Held, Brian Andrew Van Tine

Publikováno v: Cell Reports, Vol 18, Iss 4, Pp 991-1004 (2017)

Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressi

Externí odkaz: https://doaj.org/article/02d20fe490c24a00b6b854ec1ed68be3

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Akademický článek

Molecular modeling study of binding site selectivity of TQMP to G-quadruplex DNA

Autor: Aixiao, Li, François, Maurel, Florent, Barbault, Michel, Delamar, Baoshan, Wang, Xiang, Zhou, Ping, Wang

Publikováno v: In European Journal of Medicinal Chemistry 2010 45(3):983-991

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Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Autor: Jason M. Held, John S. Bomalaski, Matthew Schultze, Bethany C. Prudner, Loren S. Michel, Laura M. Shelton, Kenjiro Kami, Megan D. Radyk, S.S. Lange, Shin-Cheng Tzeng, Jeff Kremer, Gregory R. Bean, Caitlyn B. Brashears, Aixiao Li, Jon McConathy, Zack Morgan, Nathan J. Redlich, Brian A. Van Tine, Takashi Tsukamoto

Publikováno v: Cell Reports, Vol 18, Iss 4, Pp 991-1004 (2017)
Cell reports

SUMMARY Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7e6102b30cfb141c30dd4a44f37909
http://www.sciencedirect.com/science/article/pii/S2211124716317995

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Heteroaromatic and Aniline Derivatives of Piperidines As Potent Ligands for Vesicular Acetylcholine Transporter

Autor: Zhanbin Zhang, Jinquan Cui, Nigam P. Rath, Joel S. Perlmutter, Hubert Flores, Prashanth K. Padakanti, Hongjun Jin, Junfeng Li, Xiang Zhang, Dexing Zeng, Aixiao Li, Stanley M. Parsons, Zhude Tu

Publikováno v: Journal of Medicinal Chemistry. 56:6216-6233

To identify suitable lipophilic compounds having high potency and selectivity for vesicular acetylcholine transporter (VAChT), a heteroaromatic ring or a phenyl group was introduced into the carbonyl-containing scaffold for VAChT ligands. Twenty new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81dcf43def6b91c27241b0c9fc6a6f3
https://doi.org/10.1021/jm400664x

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Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands

Autor: Maninder Malik, David E. Reichert, Robert H. Mach, Qi Wang, Yogesh Mishra, Robert R. Luedtke, Shihong Li, Michelle Taylor, Aixiao Li

Publikováno v: Bioorganic & Medicinal Chemistry. 21:2988-2998

A series of N -(2-methoxyphenyl)homopiperazine analogs was prepared and their affinities for dopamine D 2 , D 3 , and D 4 receptors were measured using competitive radioligand binding assays. Several ligands exhibited high binding affinity and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4767cfa608cdcfefcd8d735c32d5abee
https://doi.org/10.1016/j.bmc.2013.03.074

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Effect of α-Methyl versus α-Hydrogen Substitution on Brain Availability and Tumor Imaging Properties of Heptanoic [F-18]Fluoroalkyl Amino Acids for Positron Emission Tomography (PET)

Autor: Jonathan McConathy, Liya Yuan, Ahlem Bouhlel, Keith M. Rich, Aixiao Li, Wadha Alyami

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2016, 59, pp.3515-31. ⟨10.1021/acs.jmedchem.6b00189⟩
Journal of Medicinal Chemistry, 2016, 59, pp.3515-31. ⟨10.1021/acs.jmedchem.6b00189⟩

International audience; Two [(18)F]fluoroalkyl substituted amino acids differing only by the presence or absence of a methyl group on the α-carbon, (S)-2-amino-7-[(18)F]fluoro-2-methylheptanoic acid ((S)-[(18)F]FAMHep, (S)-[(18)F]14) and (S)-2-amino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5664dbef4d709a47efbde7aaf1732cd
https://hal-amu.archives-ouvertes.fr/hal-01456936

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Butanethiol adsorption and dissociation on Ag (111): A periodic DFT study

Autor: Johannes Richardi, Jean-Philip Piquemal, Monica Calatayud, Aixiao Li

Publikováno v: Surface Science
Surface Science, Elsevier, 2016, 646, pp.247-252. ⟨10.1016/j.susc.2015.06.009⟩
Surface Science : A Journal Devoted to the Physics and Chemistry of Interfaces
Surface Science : A Journal Devoted to the Physics and Chemistry of Interfaces, 2016, 646, pp.247-252. ⟨10.1016/j.susc.2015.06.009⟩

International audience; The molecular and dissociative adsorption of butanethiol (C4H9SH) on regular Ag (111) surfaces has been studied by means of periodic ab initio density functional techniques. In molecular form, butanethiol is bound to the surfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cf6fd71bceec68325a9bfcd5ece51a
https://hal.sorbonne-universite.fr/hal-01171804

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ONIOM study of the nonbonding interaction of the 2PU inhibitor with the CDK2 and CDK4 cyclin-dependant kinases

Autor: Baoshan Wang, François Maurel, Michel Delamar, Aixiao Li

Publikováno v: International Journal of Quantum Chemistry. 109:1148-1157

We discuss in this article, the applicability of hybrid techniques [especially the our-own N-layered integrated molecular orbital and molecular mechanics (ONIOM) method] to weak chemical interactions in large systems, such as the interaction of cycli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02e12974317e819bd41f871327905e5c
https://doi.org/10.1002/qua.21922

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