Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Aiwen Jin"'
A role of cytoplasmic p53 in the regulation of metabolism shown by bat-mimicking p53 NLS mutant mice
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111920- (2023)
Summary: The transcription factor p53 suppresses tumorigenesis via a wide-ranging, concerted set of functions. Although several studies have identified cytoplasmic, transcription-independent functions of p53, the biological relevance of these activit
Externí odkaz:
https://doaj.org/article/4d9f3043ad5f46fcb861a6fcbdadbcba
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse models have demonstr
Externí odkaz:
https://doaj.org/article/ab4d8b9a3cc049ec95dfccafa7607574
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Obesity is increasing in prevalence and has become a global public health problem. The main cause of obesity is a perturbation in energy homeostasis, whereby energy intake exceeds energy expenditure. Although mitochondrial dysfunction has be
Externí odkaz:
https://doaj.org/article/a5a94b07e7564e258279b3d0426682af
Autor:
Derek A. Franklin, Shijie Liu, Aiwen Jin, Pengfei Cui, Zengli Guo, Kyle C. Arend, Nathaniel J. Moorman, Shenghui He, Gang Greg Wang, Yisong Y. Wan, Yanping Zhang
Publikováno v:
Journal of Biological Chemistry. 299:102739
Recent discovery of the ribosomal protein (RP) RPL11 interacting with and inhibiting the E3 ubiquitin ligase function of MDM2 established the RP-MDM2-p53 signaling pathway, which is linked to biological events, including ribosomal biogenesis, nutrien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9493f596c936624e55ee696b58b69bbc
https://doi.org/10.1016/j.jbc.2022.102739
https://doi.org/10.1016/j.jbc.2022.102739
Publikováno v:
Cancer Res
MDM2 regulates p53 degradation by functioning as an E3 ubiquitin ligase. The role of MDMX, an MDM2 homolog that lacks E3 ligase activity, in the regulation of p53 degradation remains incompletely understood and sometime controversial. This confusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb15966bfbbb2481005e1baf22db276
https://pubmed.ncbi.nlm.nih.gov/34003788
https://pubmed.ncbi.nlm.nih.gov/34003788
Publikováno v:
The FASEB Journal. 32:3892-3902
Sustained endoplasmic reticulum (ER) stress plays a major role in the development of many metabolic diseases, including cardiovascular disease, nonalcoholic fatty liver disease, insulin resistance, obesity, and diabetes. p32 is a multicompartmental p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693e942a5b34a31757e42f846a10ea93
https://doi.org/10.1096/fj.201701004rr
https://doi.org/10.1096/fj.201701004rr
Publikováno v:
Journal of Earth System Science. 126
The Lingshan Island in Shandong Province in the eastern North China Craton, well known for the Late Mesozoic multi-scale slide-slump structures is related to paleo-earthquake. Terrigenous clastic rocks, volcanic clastic rocks and volcanic lavas are e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a0e33a78af353cbcb02b35ed48d9582
https://doi.org/10.1007/s12040-017-0901-4
https://doi.org/10.1007/s12040-017-0901-4
Publikováno v:
The Journal of biological chemistry. 292(52)
The MDM2 RING domain harbors E3 ubiquitin ligase activity critical for regulating the degradation of tumor suppressor p53, which controls many cellular pathways. The MDM2 RING domain also is required for an interaction with MDMX. Mice containing a su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f52d142b4cfefc91f8bf126fc23d40
https://pubmed.ncbi.nlm.nih.gov/29123033
https://pubmed.ncbi.nlm.nih.gov/29123033
Autor:
Evan L. Busch, Weichun Huang, Yanping Zhang, Xiaojiang Xu, William K.K. Wu, Xiangchun Li, Xiaoling Li, Robert S. Sandler, Natalie S.X. Ren, Temitope O. Keku, David C. Fargo, Aiwen Jin, De Asia Lewis, Erik J. Tokar, Leping Li, Ming Ji
SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, plays a vital role in the regulation of metabolism, stress responses, and genome stability. However, the role of SIRT1 in the multi-step process leading to transformation and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3abc8c3e617c2869ce08c283e201a3
Publikováno v:
Cancer Cell. 26:235-247
Summary Mdm2 E3 ubiquitin ligase-mediated p53 degradation is generally accepted as the major mechanism for p53 regulation; nevertheless, the in vivo significance of this function has not been unequivocally established. Here, we have generated an Mdm2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d989cbce8011f382eaa5756718e2c4b9
https://doi.org/10.1016/j.ccr.2014.06.006
https://doi.org/10.1016/j.ccr.2014.06.006