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Akademický článek

An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse.

Autor: Juan Liao, Humberto B Jijon, Ira R Kim, Gautam Goel, Aivi Doan, Harry Sokol, Hermann Bauer, Bernhard G Herrmann, Kara G Lassen, Ramnik J Xavier

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108777 (2014)

The pathogenesis of complex diseases, such as type 1 diabetes (T1D), derives from interactions between host genetics and environmental factors. Previous studies have suggested that viral infection plays a significant role in initiation of T1D in gene

Externí odkaz: https://doaj.org/article/8a716f7072ec41f1b83f1494465c4e87

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Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

Autor: Daniel B. Graham, Aivi Doan, Dan Knights, Clary B. Clish, John G. Doench, Aylwin Ng, Eduardo J. Villablanca, Amanda Mok, David E. Root, Ramnik J. Xavier, Christine Becker, Gautam Goel

Publikováno v: Nature Communications

The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens. Loss-of-function mutations that impair function of the Nox2 complex result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c340852386fd03aa42a1e598d4f2d4
https://doi.org/10.1038/ncomms8838

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An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse

Autor: Hermann Bauer, Kara G. Lassen, Gautam Goel, Harry Sokol, Ramnik J. Xavier, Juan Liao, Aivi Doan, Humberto Jijon, Bernhard G. Herrmann, Ira R. Kim

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (9), pp.e108777. ⟨10.1371/journal.pone.0108777⟩
PLoS One
PLoS ONE, 2014, 9 (9), pp.e108777. ⟨10.1371/journal.pone.0108777⟩
PLoS ONE, Vol 9, Iss 9, p e108777 (2014)

International audience; The pathogenesis of complex diseases, such as type 1 diabetes (T1D), derives from interactions between host genetics and environmental factors. Previous studies have suggested that viral infection plays a significant role in i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd414a9c30ae7af847179c232746dd1e
https://hal.archives-ouvertes.fr/hal-01070301

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