Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Aive Åhgren"'
Autor:
Agnieszka Kłosowska-Wardega, Yoko Hasumi, Mikhail Burmakin, Aive Ahgren, Linda Stuhr, Ingrid Moen, Rolf K Reed, Kristofer Rubin, Carina Hellberg, Carl-Henrik Heldin
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8149 (2009)
Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (
Externí odkaz:
https://doaj.org/article/59cdccc99380471090cc1e6d18009326
Autor:
Aive Åhgren, Sara I. Cunha, Johan Lennartsson, Jessica Cedervall, Haisha Ma, Carl-Henrik Heldin, Maria Tsioumpekou, Anna-Karin Olsson
Publikováno v:
Theranostics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6008901bdbcd336ec5d25c0fd8667a3
http://europepmc.org/articles/PMC7330841
http://europepmc.org/articles/PMC7330841
Autor:
Aive Åhgren, Linda Elin Birkhaug Stuhr, P. Olof Olsson, Carina Hellberg, Rolf K. Reed, Mikhail Burmakin, Tijs van Wieringen, Kristofer Rubin, Carl-Henrik Heldin
Publikováno v:
Journal of Translational Medicine
Background: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acec670c071118011be031f3c4dc5fa7
http://europepmc.org/articles/PMC5324310
http://europepmc.org/articles/PMC5324310
Autor:
Yan Wu, Rainer Heuchel, Aive Åhgren, Lena Claesson-Welsh, Peetra U. Magnusson, Camilla Looman
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:2142-2149
Objective— Knockout studies have demonstrated crucial roles for the platelet-derived growth factor-B and its cognate receptor, platelet-derived growth factor receptor-β (PDGFR-β), in blood vessel maturation, that is, the coverage of newly formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b12b5435d9583f93b7b780ead8c40fe
https://doi.org/10.1161/01.atv.0000282198.60701.94
https://doi.org/10.1161/01.atv.0000282198.60701.94
Autor:
Rainer Heuchel, Christina Sundquist, Greger Brodin, Tony Pawson, Alexander Rosendahl, Sarang Kulkarni, Carl-Henrik Heldin, Ronggui Li, Alec M. Cheng, Aive Åhgren
Publikováno v:
Karolinska Institutet
The members of the TGF-β superfamily, i.e., TGF-β isoforms, activins, and bone morphogenetic proteins, regulate growth, differentiation, and apoptosis, both during embryonic development and during postnatal life. Smad7 is induced by the TGF-β supe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776c4547cdb96823e021c75cb48c1f25
https://doi.org/10.4049/jimmunol.176.11.6777
https://doi.org/10.4049/jimmunol.176.11.6777
Publikováno v:
Journal of Biological Chemistry. 275:29023-29030
Sma- and Mad-related protein 7 (Smad7) is an antagonist of transforming growth factor-beta (TGF-beta) signaling, which has been shown to be induced by TGF-beta itself and also by other stimuli. In an effort to understand the molecular mechanisms unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25096b55cbb50da24f88ded4622e19a4
https://doi.org/10.1074/jbc.m002815200
https://doi.org/10.1074/jbc.m002815200
Autor:
Aive Åhgren, Per Odin, Olle Lindvall, Klas Wictorin, K Pietz, Greger Brodin, N. Yamada, Keiko Funa
Publikováno v:
Neuroscience. 74:825-833
The kinetics of platelet-derived growth factor messenger RNA synthesis in the substantia nigra and in the striatum, before and after unilateral intranigral 6-hydroxydopamine injection, was studied and compared with that after sham operation by a quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321124b47939a6b38cc965bffe511810
https://doi.org/10.1016/0306-4522(96)00152-2
https://doi.org/10.1016/0306-4522(96)00152-2
Publikováno v:
Melanoma research. 21(1)
Melanomas respond poorly to chemotherapy. In this study, we investigated the sensitization of B16 mouse melanoma tumors to paclitaxel by a combination of two tyrosine kinase inhibitors: vatalanib, targeting vascular endothelial growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ff7637276ffc439fb9a1fd34788fb8
https://pubmed.ncbi.nlm.nih.gov/20975605
https://pubmed.ncbi.nlm.nih.gov/20975605
Previous studies showed that loss of the T-cell protein tyrosine phosphatase (TC-PTP) induces Rab4a-dependent recycling of the platelet-derived growth factor (PDGF) beta-receptor in mouse embryonic fibroblasts (MEFs). Here we identify protein kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3441153b074220c0fbdbb96026045104
https://europepmc.org/articles/PMC2695793/
https://europepmc.org/articles/PMC2695793/
Autor:
Carl-Henrik Heldin, Henrik Forsberg, Nelson Khoo, Ricardo Feinstein, Karin Forsberg-Nilsson, Camilla Looman, Rainer Heuchel, Reinald Fundele, Aive Åhgren, Agata Zieba, Yang Yu, Tong Sun, Xiao-Qun Zhang, Carina Hellberg
Publikováno v:
The International journal of developmental biology. 51(5)
An oncogenic D842V mutation in the platelet-derived growth factor (PDGF) alpha-receptor (Pdgfra) has recently been described in patients with gastrointestinal stromal tumors. In order to test if the same mutation would confer oncogenic properties to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f912c0d65d929cc2379eea77d9275008
https://pubmed.ncbi.nlm.nih.gov/17616925
https://pubmed.ncbi.nlm.nih.gov/17616925