Aromatic stacking interactions govern catalysis in aryl-alcohol oxidase

Autor: Ángel T. Martínez, Kenneth W. Borrelli, Victor Guallar, Patricia Ferreira, Aitor Hernández-Ortega, Milagros Medina, Juan Carro, Fátima Lucas, Beatriz Herguedas

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
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UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

This is the peer reviewed version of the following article: [Ferreira, P., Hernández-Ortega, A., Lucas, F., Carro, J., Herguedas, B., Borrelli, K. W., Guallar, V., Martínez, A. T. and Medina, M. (2015), Aromatic stacking interactions govern catalys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db102798f531510f9781a9435fdbb8
https://doi.org/10.1111/febs.13221

Role of Active Site Histidines in the Two Half-Reactions of the Aryl-Alcohol Oxidase Catalytic Cycle

Autor: Aitor Hernández-Ortega, Milagros Medina, Victor Guallar, Fátima Lucas, Ángel T. Martínez, Patricia Ferreira

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Biochemistry

The crystal structure of aryl-alcohol oxidase (AAO), a flavoenzyme involved in lignin degradation, reveals two active-site histidines, whose role in the two enzyme half-reactions was investigated. The redox state of flavin during turnover of the vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4533e28c983b5dfbaaeaf1a28d54fe01
https://doi.org/10.1021/bi300505z

Modulating O2 Reactivity in a Fungal Flavoenzyme

Autor: Milagros Medina, Aitor Hernández-Ortega, Victor Guallar, Ángel T. Martínez, Patricia Ferreira, Fátima Lucas

Publikováno v: Journal of Biological Chemistry. 286:41105-41114

Aryl-alcohol oxidase (AAO) is a flavoenzyme responsible for activation of O(2) to H(2)O(2) in fungal degradation of lignin. The AAO crystal structure shows a buried active site connected to the solvent by a hydrophobic funnel-shaped channel, with Phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::495635ca2d88335829deee5c0c98845b
https://doi.org/10.1074/jbc.m111.282467

Modulating O2 reactivity in a fungal flavoenzyme: involvement of aryl-alcohol oxidase Phe-501 contiguous to catalytic histidine

Autor: Aitor, Hernández-Ortega, Fátima, Lucas, Patricia, Ferreira, Milagros, Medina, Victor, Guallar, Angel T, Martínez

Publikováno v: The Journal of biological chemistry. 286(47)

Aryl-alcohol oxidase (AAO) is a flavoenzyme responsible for activation of O(2) to H(2)O(2) in fungal degradation of lignin. The AAO crystal structure shows a buried active site connected to the solvent by a hydrophobic funnel-shaped channel, with Phe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7527715af303524afee76d2b692c4cb0
https://pubmed.ncbi.nlm.nih.gov/21940622

Kinetic and chemical characterization of aldehyde oxidation by fungal aryl-alcohol oxidase

Autor: María Jesús Martínez, Jesús Jiménez-Barbero, Aitor Hernández-Ortega, Ángel T. Martínez, Jorge Rencoret, Beatriz Herguedas, Milagros Medina, Ana Gutiérrez, Patricia Ferreira

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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9 páginas, 6 figuras, 3 tablas -- PAGS nros. 585-593
Fungal AAO (aryl-alcohol oxidase) provides H2O2 for lignin biodegradation. AAO is active on benzyl alcohols that are oxidized to aldehydes. However, during oxidation of some alcohols, AAO for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4308ea7bca66665f9235bacc8ee6959
https://pubmed.ncbi.nlm.nih.gov/19891608