Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease

Autor: Marc F. Österdahl, Ronan Whiston, Carole H. Sudre, Francesco Asnicar, Nathan J. Cheetham, Aitor Blanco Miguez, Vicky Bowyer, Michela Antonelli, Olivia Snell, Liane dos Santos Canas, Christina Hu, Jonathan Wolf, Cristina Menni, Michael Malim, Deborah Hart, Tim Spector, Sarah Berry, Nicola Segata, Katie Doores, Sebastien Ourselin, Emma L. Duncan, Claire J. Steves

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Whilst most individuals with SARS-CoV-2 infection have relatively mild disease, managed in the community, it was noted early in the pandemic that individuals with cardiovascular risk factors were more likely to experience severe acute diseas

Externí odkaz: https://doaj.org/article/f8140cf6129b4dc1aa089ecc0e0465f6

Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

Autor: Gianluca Ianiro, Ernesto Rossi, Andrew M. Thomas, Giovanni Schinzari, Luca Masucci, Gianluca Quaranta, Carlo Romano Settanni, Loris Riccardo Lopetuso, Federica Armanini, Aitor Blanco-Miguez, Francesco Asnicar, Clarissa Consolandi, Roberto Iacovelli, Maurizio Sanguinetti, Giampaolo Tortora, Antonio Gasbarrini, Nicola Segata, Giovanni Cammarota

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)

Tyrosine kinase inhibitors (TKIs) have improved the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC), however TKI-related diarrhoea is a common and serious adverse effect. Here the authors show in a randomized clinical trial

Externí odkaz: https://doaj.org/article/ab5ae20fc58c49258c28693a84568fb9

Extending and improving metagenomic taxonomic profiling with uncharacterized species with MetaPhlAn 4

Autor: Aitor Blanco-Miguez, Francesco Beghini, Fabio Cumbo, Lauren J. McIver, Kelsey N. Thompson, Moreno Zolfo, Paolo Manghi, Leonard Dubois, Kun D. Huang, Andrew Maltez Thomas, Gianmarco Piccinno, Elisa Piperni, Michal Punčochář, Mireia Valles-Colomer, Adrian Tett, Francesca Giordano, Richard Davies, Jonathan Wolf, Sarah E. Berry, Tim D. Spector, Eric A. Franzosa, Edoardo Pasolli, Francesco Asnicar, Curtis Huttenhower, Nicola Segata

Metagenomic assembly enables novel organism discovery from microbial communities, but from most metagenomes it can only capture few abundant organisms. Here, we present a method - MetaPhlAn 4 - to integrate information from both metagenome assemblies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b376050ffa0e3cd952c48beffc30ad7d
https://doi.org/10.1101/2022.08.22.504593

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Autor: Karla A. Lee, Andrew Maltez Thomas, Laura A. Bolte, Johannes R. Björk, Laura Kist de Ruijter, Federica Armanini, Francesco Asnicar, Aitor Blanco-Miguez, Ruth Board, Neus Calbet-Llopart, Lisa Derosa, Nathalie Dhomen, Kelly Brooks, Mark Harland, Mark Harries, Emily R. Leeming, Paul Lorigan, Paolo Manghi, Richard Marais, Julia Newton-Bishop, Luigi Nezi, Federica Pinto, Miriam Potrony, Susana Puig, Patricio Serra-Bellver, Heather M. Shaw, Sabrina Tamburini, Sara Valpione, Amrita Vijay, Levi Waldron, Laurence Zitvogel, Moreno Zolfo, Elisabeth G. E. de Vries, Paul Nathan, Rudolf S. N. Fehrmann, Véronique Bataille, Geke A. P. Hospers, Tim D. Spector, Rinse K. Weersma, Nicola Segata

Publikováno v: Nature Medicine
Lee, K A, Thomas, A M, Bolte, L A, Björk, J R, de Ruijter, L K, Armanini, F, Asnicar, F, Blanco-Miguez, A, Board, R, Calbet-Llopart, N, Derosa, L, Dhomen, N, Brooks, K, Harland, M, Harries, M, Leeming, E R, Lorigan, P, Manghi, P, Marais, R, Newton-Bishop, J, Nezi, L, Pinto, F, Potrony, M, Puig, S, Serra-Bellver, P, Shaw, H M, Tamburini, S, Valpione, S, Vijay, A, Waldron, L, Zitvogel, L, Zolfo, M, de Vries, E G E, Nathan, P, Fehrmann, R S N, Bataille, V, Hospers, G A P, Spector, T D, Weersma, R K & Segata, N 2022, ' Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma ', Nature Medicine, vol. 28, no. 3, pp. 535-544 . https://doi.org/10.1038/s41591-022-01695-5
Nature Medicine, 28. Nature Publishing Group

The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs. We pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d9010bfaf4e6f5e7f69e6b0bbaca17

Favorable subgingival plaque microbiome shifts are associated with clinical treatment for peri-implant diseases

Autor: Davide Bazzani, Vitor Heidrich, Paolo Manghi, Aitor Blanco-Miguez, Francesco Asnicar, Federica Armanini, Sara Cavaliere, Alberto Bertelle, Federico Dell’Acqua, Ester Dellasega, Romina Waldner, Daniela Vicentini, Mattia Bolzan, Cristiano Tomasi, Nicola Segata, Edoardo Pasolli, Paolo Ghensi

Publikováno v: npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-6 (2024)

Abstract We performed a longitudinal shotgun metagenomic investigation of the plaque microbiome associated with peri-implant diseases in a cohort of 91 subjects with 320 quality-controlled metagenomes. Through recently improved taxonomic profiling me

Externí odkaz: https://doaj.org/article/2d04f015a40d414fb7bfae7aa85d0f97