Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aitor Almanza"'
Autor:
Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lip
Externí odkaz:
https://doaj.org/article/5880a9d0a80d435dbe79e1dfb4bc9b6f
Autor:
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel
Externí odkaz:
https://doaj.org/article/397f4e630bac42c587fdf199a5689e3f
Autor:
Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.2493. ⟨10.1038/s41467-022-30159-0⟩
Nature Communications, Nature Publishing Group, 2022, 13 (1), pp.2493. ⟨10.1038/s41467-022-30159-0⟩
Nature Communications, 2022, 13 (1), pp.2493. ⟨10.1038/s41467-022-30159-0⟩
Nature Communications, Nature Publishing Group, 2022, 13 (1), pp.2493. ⟨10.1038/s41467-022-30159-0⟩
International audience; IRE1 alpha cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1 alpha cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08fc426af9ec8fffb43f08a2f2741b0
https://hal.science/hal-03689648/document
https://hal.science/hal-03689648/document
Autor:
Aitor Almanza, Matthieu Moncan, Afshin Samali, Katarzyna Mnich, Arnaud Blomme, Adrienne M. Gorman
Publikováno v:
Journal of Cellular and Molecular Medicine
The endoplasmic reticulum (ER) is the site of protein folding and secretion, Ca2+ storage and lipid synthesis in eukaryotic cells. Disruption to protein folding or Ca2+ homeostasis in the ER leads to the accumulation of unfolded proteins, a condition
Autor:
Aitor Almanza, Antonio Carlesso, Chetan Chintha, Stuart Creedican, Dimitrios Doultsinos, Brian Leuzzi, Andreia Luís, Nicole McCarthy, Luigi Montibeller, Sanket More, Alexandra Papaioannou, Franziska Püschel, Maria Livia Sassano, Josip Skoko, Patrizia Agostinis, Jackie de Belleroche, Leif A. Eriksson, Simone Fulda, Adrienne M. Gorman, Sandra Healy, Andrey Kozlov, Cristina Muñoz-Pinedo, Markus Re
Publikováno v:
The FEBS Journal
Autor:
Roisin M. Dwyer, Katarzyna Mnich, Qingping Zeng, Patrick Legembre, Aitor Almanza, Stephanie Greene, Anup M. Oommen, Adrienne M. Gorman, Eoghan P. McGrath, Susan E. Logue, Emma C. Madden, Brian Leuzzi, Patricia Cleary, Richard Jäger, John B. Patterson, Joanna Obacz, Florence Godey, Eric Chevet, Afshin Samali
Publikováno v:
Nature Communications
Nature Communications, 2018, 9 (1), pp.3267. ⟨10.1038/s41467-018-05763-8⟩
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3267. ⟨10.1038/s41467-018-05763-8⟩
Nature Communications volume 9, Article number: 3267 (2018)
Nature Communications, 2018, 9 (1), pp.3267. ⟨10.1038/s41467-018-05763-8⟩
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3267. ⟨10.1038/s41467-018-05763-8⟩
Nature Communications volume 9, Article number: 3267 (2018)
Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets and strategies. IRE1 is an endoplasmic reticulum (ER) stress sensor, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c324c3d8df702f0f8560ed080b377b31
https://univ-rennes.hal.science/hal-01879955
https://univ-rennes.hal.science/hal-01879955
Autor:
Adrienne M. Gorman, Katarzyna Mnich, Jennifer Hillis, Susan E. Logue, Sarah Dolan, Rola Jaafar, Aitor Almanza, Afshin Samali
Publikováno v:
Biochemical and Biophysical Research Communications
Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple negative breast cancer (TNBC