Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Aitor Aguirre"'
Autor:
Aixia Sun, MD, PhD, Hanaan Hayat, BS, Elizabeth Kenyon, MS, Tahnia Quadri, BS, Darius Amos, BS, Keenan Perkins, BS, Saumya Nigam, PhD, Deanna Tarleton, BS, Christiane L. Mallett, PhD, Cheri X. Deng, PhD, Zhen Qiu, PhD, Wen Li, PhD, Lorenzo Sempere, PhD, Jinda Fan, PhD, Aitor Aguirre, PhD, Ping Wang, MD, PhD
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1658 (2024)
Background. Transplantation of human-induced pluripotent stem cell (hiPSC)-derived islet organoids is a promising cell replacement therapy for type 1 diabetes (T1D). It is important to improve the efficacy of islet organoids transplantation by identi
Externí odkaz:
https://doaj.org/article/3f037444dfe7407295fe2c837d727b56
Autor:
Brett Volmert, Artem Kiselev, Aniwat Juhong, Fei Wang, Ashlin Riggs, Aleksandra Kostina, Colin O’Hern, Priyadharshni Muniyandi, Aaron Wasserman, Amanda Huang, Yonatan Lewis-Israeli, Vishal Panda, Sudin Bhattacharya, Adam Lauver, Sangbum Park, Zhen Qiu, Chao Zhou, Aitor Aguirre
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and horm
Externí odkaz:
https://doaj.org/article/8291423851734cc79c4f8ca9fb65ced5
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
In recent years, significant biotechnological advancements have been made in engineering human cardiac tissues and organ-like models. This field of research is crucial for both basic and translational research due to cardiovascular disease being the
Externí odkaz:
https://doaj.org/article/588887932c4342ea8360696a4b72ce9c
Autor:
Aaron H. Wasserman, Amanda R. Huang, Yonatan R. Lewis-Israeli, McKenna D. Dooley, Allison L. Mitchell, Manigandan Venkatesan, Aitor Aguirre
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and frequently leads to massive heart injury and the loss of billions of cardiac muscle cells and associated vasculature. Critical work in the last 2 decades demonstrat
Externí odkaz:
https://doaj.org/article/283c2704b6c54bacba4c1b6407dfa967
Autor:
Yonatan R. Lewis-Israeli, Aaron H. Wasserman, Mitchell A. Gabalski, Brett D. Volmert, Yixuan Ming, Kristen A. Ball, Weiyang Yang, Jinyun Zou, Guangming Ni, Natalia Pajares, Xanthippi Chatzistavrou, Wen Li, Chao Zhou, Aitor Aguirre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly us
Externí odkaz:
https://doaj.org/article/253ca09085994e7ca7cf500eaaf085e0
Autor:
Valerie Sapp, Aitor Aguirre, Gayatri Mainkar, Jeffrey Ding, Eric Adler, Ronglih Liao, Sonia Sharma, Mohit Jain
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Human induced pluripotent stem (iPS) cell technologies coupled with genetic engineering now facilitate the study of the molecular underpinnings of disease in relevant human cell types. Application of CRISPR/Cas9-based approaches for genome-s
Externí odkaz:
https://doaj.org/article/3e7b6bbe20104376830c9ac969a7c0df
Autor:
Aixia Sun, Hasaan Hayat, Sihai Liu, Eliah Tull, Jack Owen Bishop, Bennett Francis Dwan, Mithil Gudi, Nazanin Talebloo, James Raynard Dizon, Wen Li, Jeffery Gaudet, Adam Alessio, Aitor Aguirre, Ping Wang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Stem cell-derived islet organoids constitute a promising treatment of type 1 diabetes. A major hurdle in the field is the lack of appropriate in vivo method to determine graft outcome. Here, we investigate the feasibility of in vivo tracking of trans
Externí odkaz:
https://doaj.org/article/a917e81ceb16480b9fdd3003dc44dd0a
Autor:
Xin Zhao, Haodong Chen, Dan Xiao, Huaxiao Yang, Ilanit Itzhaki, Xulei Qin, Tony Chour, Aitor Aguirre, Kim Lehmann, Youngkyun Kim, Praveen Shukla, Alexandra Holmström, Joe Z. Zhang, Yan Zhuge, Babacar C. Ndoye, Mingtao Zhao, Evgenios Neofytou, Wolfram-Hubertus Zimmermann, Mohit Jain, Joseph C. Wu
Publikováno v:
Stem Cell Reports, Vol 10, Iss 2, Pp 422-435 (2018)
Summary: Non-human primates (NHPs) can serve as a human-like model to study cell therapy using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). However, whether the efficacy of NHP and human iPSC-CMs is mechanistically similar remains
Externí odkaz:
https://doaj.org/article/36e733e5361c4151a7464440fb1bf308
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1277 (2021)
Organoids are three-dimensional in vitro cell constructs that recapitulate organ properties and structure to a significant extent. They constitute particularly useful models to study unapproachable states in humans, such as embryonic and fetal develo
Externí odkaz:
https://doaj.org/article/fb40f8e9f6a247b38756c3d4aebf9b19
Autor:
Athanasia D. Panopoulos, Matteo D'Antonio, Paola Benaglio, Roy Williams, Sherin I. Hashem, Bernhard M. Schuldt, Christopher DeBoever, Angelo D. Arias, Melvin Garcia, Bradley C. Nelson, Olivier Harismendy, David A. Jakubosky, Margaret K.R. Donovan, William W. Greenwald, KathyJean Farnam, Megan Cook, Victor Borja, Carl A. Miller, Jonathan D. Grinstein, Frauke Drees, Jonathan Okubo, Kenneth E. Diffenderfer, Yuriko Hishida, Veronica Modesto, Carl T. Dargitz, Rachel Feiring, Chang Zhao, Aitor Aguirre, Thomas J. McGarry, Hiroko Matsui, He Li, Joaquin Reyna, Fangwen Rao, Daniel T. O'Connor, Gene W. Yeo, Sylvia M. Evans, Neil C. Chi, Kristen Jepsen, Naoki Nariai, Franz-Josef Müller, Lawrence S.B. Goldstein, Juan Carlos Izpisua Belmonte, Eric Adler, Jeanne F. Loring, W. Travis Berggren, Agnieszka D'Antonio-Chronowska, Erin N. Smith, Kelly A. Frazer
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 1086-1100 (2017)
Summary: Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease. Here we describe the iPSCORE resource: a collection of systematically de
Externí odkaz:
https://doaj.org/article/c8ae55149e0944118b67d5bad7b79cfa