Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation

Autor: Shinji Okabayashi, Toshifumi Hibi, Shintaro Sagami, Hiroki Kiyohara, Aito Ueno, Masaru Nakano, Osamu Takeuchi, Sally A. Coulthard, Christopher P.F. Redfern, Hideki Terai, Satoshi Kuronuma, Yoichi Tanaka, Taku Kobayashi, Takahiko Toyonaga, Ryo Ozaki

Publikováno v: Journal of Gastroenterology. 56:999-1007

Polymorphisms in the nucleotide diphosphate-linked moiety X-type motif 15 (NUDT15) gene are associated with thiopurine-induced leukopenia in patients with inflammatory bowel disease (IBD). NUDT15-associated subcellular thiopurine metabolism has not b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e976a8ae3a937935dc7f0a710b6798
https://doi.org/10.1007/s00535-021-01820-0

Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3−/− Mice

Autor: Simon A. Hirota, Aito Ueno, Sarah E. Tulk, Helen M. Becker, L. Patrick Schenck, Mireille S. Potentier, Yan Li, Subrata Ghosh, Daniel A. Muruve, Justin A. MacDonald, Paul L. Beck

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

The pathogenesis of Crohn’s disease (CD) involves defects in the innate immune system, impairing responses to microbes. Studies have revealed that mutations NLRP3 are associated with CD. We reported previously that Nlrp3−/− mice were more susce

Externí odkaz: https://doaj.org/article/672a27eea8bb4adcb334cb3fea64eedc

Crossover Subsets of CD4+ T Lymphocytes in the Intestinal Lamina Propria of Patients with Crohn’s Disease and Ulcerative Colitis

Autor: Aito Ueno, Miriam Fort Gasia, Joanne Luider, Xianyong Gui, Ji Li, Marietta Iacucci, Jiaming Qian, Subrata Ghosh, Gilaad G. Kaplan, Paul L. Beck, Remo Panaccione, Humberto Jijon, Herman W. Barkema

Publikováno v: Digestive Diseases and Sciences. 62:2357-2368

Hovhannisyan et al. first showed evidence of plasticity between Treg and Th17 in the inflamed intestine of Crohn’s disease (CD) patients. Our previous report suggests that the inflammatory cytokine milieu generates IL-17+ Foxp3+ CD4+ T lymphocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31aabc1d3be4ee472d2eeb73f91346e2
https://doi.org/10.1007/s10620-017-4596-9

Immunogenicity of Influenza Vaccine for Patients with Inflammatory Bowel Disease on Maintenance Infliximab Therapy

Autor: Iwona Wrobel, Aito Ueno, Kevin Fonseca, Jennifer deBruyn, Miriam Fort Gasia, Cynthia H. Seow, Subrata Ghosh, Gilaad G. Kaplan, Remo Panaccione

Publikováno v: Inflammatory Bowel Diseases. 22:638-647

Background In patients with inflammatory bowel disease (IBD) on infliximab, data are limited on immune response to influenza vaccine and the impact of vaccine timing. The study aims were to evaluate immune responses to the influenza vaccine in IBD pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f852386d77ee6f6a7f827290cf2968
https://doi.org/10.1097/mib.0000000000000615

Dietary n-3 PUFA May Attenuate Experimental Colitis

Autor: Aito Ueno, Charlène Guérin, Khaly Mbodji, E. Salameh, Moïse Coëffier, Guillaume Savoye, Subrata Ghosh, Cloé Charpentier, Rachel Marion-Letellier, Ronald Chan

Publikováno v: Mediators of Inflammation
Mediators of Inflammation, 2018, 2018, pp.1-10. ⟨10.1155/2018/8430614⟩
Mediators of Inflammation, Vol 2018 (2018)
Mediators of Inflammation, Hindawi Publishing Corporation, 2018, 2018, pp.1-10. ⟨10.1155/2018/8430614⟩

Background. Inflammatory bowel diseases (IBD) occurred in genetically predisposed people exposed to environmental triggers. Diet has long been suspected to contribute to the development of IBD. Supplementation with n-3 polyunsaturated fatty acids (PU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343ef9b4295e0e175cee39e0a1ffada4
https://hal-normandie-univ.archives-ouvertes.fr/hal-02315973