Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Aiste Dobrovolskaite"'
Autor:
Aiste Dobrovolskaite, Holly Moots, Mukund P. Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M. Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel
Publikováno v:
Journal of medicinal chemistry. 65(22)
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid de
Publikováno v:
ACS Med Chem Lett
[Image: see text] Nine- and twelve-membered triaza-macrocycles were appended to one end of homospermidine to make polyamine lassos. These compounds were shown to be potent polyamine transport inhibitors (PTIs) using pancreatic ductal adenocarcinoma L
Publikováno v:
The international journal of biochemistrycell biology. 138
The native polyamines putrescine, spermidine, and spermine are essential for cell development and proliferation. Polyamine levels are often increased in cancer tissues and polyamine depletion is a validated anticancer strategy. Cancer cell growth can
Generation of a Difluoromethylornithine (DFMO) Resistant Cell Line in a Polyamine Depletion Strategy
Publikováno v:
The FASEB Journal. 33