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of 4
pro vyhledávání: '"Aislinn Davis"'
Autor:
Adam Nelson, Evan Beatty, Qi Yao, Huaiyuan Zhang, Sana Basheer, Honghong Zhang, Jialing Xiang, Jiajun Li, Adriana Mañas, Aislinn Davis
Publikováno v:
Histochem Cell Biol
The pro-apoptotic Bax isoform Bax∆2 was originally discovered in cancer patients with a microsatellite guanine deletion (G8 to G7). This deletion leads to an early stop codon; however, when combined with the alternative splicing of exon 2, the read
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a758ae45295c5a0cae2bb57e86691b31
https://doi.org/10.1007/s00418-020-01874-w
https://doi.org/10.1007/s00418-020-01874-w
Publikováno v:
Histochem Cell Biol
Bax∆2 is a pro-apoptotic protein originally discovered in colon cancer patients with high microsatellite instability. Unlike most pro-apoptotic Bax family members, Bax∆2 mediates cell death through a non-mitochondrial caspase 8-dependent pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0264ab9bd70b5a2f2839d7e3d626a56
https://pubmed.ncbi.nlm.nih.gov/29663074
https://pubmed.ncbi.nlm.nih.gov/29663074
BaxΔ2 is a pro-apoptotic protein originally discovered in colon cancer patients with high microsatellite instability. Unlike most pro-apoptotic Bax family members, BaxΔ2 mediates cell death through a non-mitochondrial caspase 8-dependent pathway. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3763e56fb7be790881a26f5956dd9dc
Autor:
Sheng Wang, Adam Nelson, Jiajun Li, Aislinn Davis, Natalia Maltsev, Jialing Xiang, Huaiyuan Zhang, Bingqing Xie, Adriana Mañas, Yu Zhao
Bax∆2 is a functional pro-apoptotic Bax isoform having alterations in its N-terminus, but sharing the rest of its sequence with Baxα. Bax∆2 is unable to target mitochondria due to the loss of helix α1. Instead, it forms cytosolic aggregates and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08202a60924f0712806a47a9aaf4bb8e
https://europepmc.org/articles/PMC5718386/
https://europepmc.org/articles/PMC5718386/