Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Aisling O'Connor"'
Autor:
V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O’Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.
Externí odkaz:
https://doaj.org/article/dae63874a0924b7f84dd69ccfd135eb0
Autor:
Aisling O'Connor, Stefano Maffini, Michael D. Rainey, Agnieszka Kaczmarczyk, David Gaboriau, Andrea Musacchio, Corrado Santocanale
Publikováno v:
Biology Open, Vol 5, Iss 1, Pp 11-19 (2016)
During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis a
Externí odkaz:
https://doaj.org/article/30497ac5bbca4166bfe855c71f973413
Autor:
Jennifer FitzGerald, Laura S Murillo, Gemma O'Brien, Enda O'Connell, Aisling O'Connor, Kevin Wu, Guan-Nan Wang, Michael D Rainey, Alessandro Natoni, Sandra Healy, Michael O'Dwyer, Corrado Santocanale
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98891 (2014)
DNA replication is an essential process for cell division and as such it is a process that is directly targeted by several anticancer drugs. CDC7 plays an essential role in the activation of replication origins and has recently been proposed as a nov
Externí odkaz:
https://doaj.org/article/b69c88669d624433bb47d1a6f247bf37
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
HT10806TG_CBL0137 treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a65865b88e665572993028e81a66b25
https://doi.org/10.1158/1078-0432.22481328.v1
https://doi.org/10.1158/1078-0432.22481328.v1
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
Supplementary Figure Legends S1-S16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418baa2ab5037ab880d09c89a3ddcd0f
https://doi.org/10.1158/1078-0432.22481343.v1
https://doi.org/10.1158/1078-0432.22481343.v1
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
Purpose:We investigated whether targeting chromatin stability through a combination of the curaxin CBL0137 with the histone deacetylase (HDAC) inhibitor, panobinostat, constitutes an effective multimodal treatment for high-risk neuroblastoma.Experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d195a8f4885e0b0f8fe998d3c3ca58
https://doi.org/10.1158/1078-0432.c.6530664.v1
https://doi.org/10.1158/1078-0432.c.6530664.v1
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
Supplementary Figures S1-S16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792fea8161528a9cd8c896589616c6d0
https://doi.org/10.1158/1078-0432.22481337
https://doi.org/10.1158/1078-0432.22481337
Autor:
Michelle Haber, Murray D. Norris, Katerina V. Gurova, Andrei V. Gudkov, David S. Ziegler, Anthony J. Cesare, Ricky W. Johnstone, Glenn Marshall, Jamie I. Fletcher, Michelle J. Henderson, Daniel R. Carter, Andrew J. Gifford, Alvin Kamili, Lei Zhai, Sophie Allan, Stephanie Alfred, Georgina Eden, Adam Kearns, Erin Mosmann, Jessica A. Pettitt, Frances K. Kusuma, Jennifer Brand, Hazel Quek, Pooja Venkat, Chelsea Mayoh, Aisling O'Connor, Katerina I. Leonova, Natalia Issaeva, Laura D. Gamble, Anahid Ehteda, Rachael Terry, Angelika Bongers, Emma Ronca, Mawar Karsa, Ruby Pandher, Jayne Murray, Klaartje Somers, Lin Xiao
Supplementary Tables S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c658b9df3d28c8753a0e6dc9fa2665
https://doi.org/10.1158/1078-0432.22481334
https://doi.org/10.1158/1078-0432.22481334
Autor:
Tara McDonnell, Aisling O'Connor, Leanne Cussen, Doyle Lauren Madden, Hannah Forde, Diarmuid Smith, Michael W. O'Reilly
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce2ddfd9f960671bb4f46ed78eb6fa7a
https://doi.org/10.1530/endoabs.86.p358
https://doi.org/10.1530/endoabs.86.p358
Autor:
Laura D. Gamble, Ricky W. Johnstone, Klaartje Somers, Rachael L. Terry, Glenn M. Marshall, Andrei V. Gudkov, Sophie Allan, Georgina L. Eden, Jamie I. Fletcher, Frances K. Kusuma, Stephanie Alfred, Mawar Karsa, Adam Kearns, Michelle J. Henderson, Michelle Haber, Angelika Bongers, Katerina Gurova, Lin Xiao, Anahid Ehteda, Lei Zhai, Erin Mosmann, Katerina I. Leonova, Natalia Issaeva, Pooja Venkat, Aisling O'Connor, Alvin Kamili, David S. Ziegler, Ruby Pandher, Daniel R. Carter, Hazel Quek, Andrew J. Gifford, Jayne Murray, Chelsea Mayoh, Jessica A. Pettitt, Murray D. Norris, Jennifer Brand, Emma Ronca, Anthony J. Cesare
Publikováno v:
Clin Cancer Res
Purpose: We investigated whether targeting chromatin stability through a combination of the curaxin CBL0137 with the histone deacetylase (HDAC) inhibitor, panobinostat, constitutes an effective multimodal treatment for high-risk neuroblastoma. Experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c3b3a2e94178e093b7aaba1149e5f6
https://doi.org/10.1158/1078-0432.ccr-20-2357
https://doi.org/10.1158/1078-0432.ccr-20-2357